Zobrazeno 21 - 30
of 112
pro vyhledávání: '"Morris, D."'
Autor:
Mohammed M. Dar, Patrick Y. Wen, Tom Mikkelsen, Roger E. McLendon, Jorge Barriuso, Morris D. Groves, David A. Reardon, Jeffrey J. Raizer, Louis B. Nabors, A. Benjamin Suttle, C. Martin Curtis, Steve Rosenfeld, Johann S. de Bono, Bo Ma
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 19(4)
Purpose: Increased mitogenic signaling and angiogenesis, frequently facilitated by somatic activation of EGF receptor (EGFR; ErbB1) and/or loss of PTEN, and VEGF overexpression, respectively, drive malignant glioma growth. We hypothesized that patien
Autor:
Morris D. Cooper, Anne M. Rompalo
Any area of the body may be involved with sexually transmitted infections, and many critical anatomical points may be important in some context of their diagnosis. In general, there are two major differences in the anatomy and the examination between
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::81a682861910bc5c2f99b7f81d1406e9
https://doi.org/10.1016/b978-0-12-391059-2.00002-4
https://doi.org/10.1016/b978-0-12-391059-2.00002-4
Autor:
Mark A. Goldsmith, Morris D. White, Kathleen D. Liu, Jennifer M. Puck, Jaime Molden, Stephen Y. Lai
Publikováno v:
The EMBO Journal. 15:4506-4514
Interleukin-4 (IL-4) exerts its effects through a heterodimeric receptor complex (IL-4R), which contains the IL-4R(alpha) and gamma(c) subunits. IL-4R(alpha) also functions with other partner subunits in several receptor types, including the IL-13 re
Autor:
Morris D. Faiman, Bruch W. Hart
Publikováno v:
Biochemical Pharmacology. 49:157-163
S-Methyl N,N-diethylthiolcarbamate (DETC-Me) is a metabolite formed during the bioactivation of disulfiram. The formation of its corresponding sulfoxide, S-methyl N,N-diethylthiolcarbamate sulfoxide (DETC-MeSO), from DETC-Me is required for low Km mi
Publikováno v:
American journal of reproductive immunology (New York, N.Y. : 1989). 68(2)
Secretory leukocyte protease inhibitor (SLPI) is an innate immune peptide present on the genitourinary tract mucosa that has antimicrobial activity. In this study, we investigated the interaction of SLPI with Neisseria gonorrhoeae.ELISA and far-Weste
Autor:
Morris D. Faiman, Bruce W. Hart
Publikováno v:
Alcoholism: Clinical and Experimental Research. 18:340-345
S-methyl N,N-diethylthiolcarbamate sulfoxide (DETC-MeSO) is proposed to be the metabolite of disulfiram responsible for the in vivo inhibition of liver low Km, aldehyde dehydrogenase (ALDH) in the rat. Studies were conducted in male Sprague-Dawley ra
Publikováno v:
Biochemical Pharmacology. 46:2291-2297
Disulfiram is bioactivated to S-methyl N,N-diethylthiolcarbamate sulfoxide (DETC-MeSO), the metabolite proposed to be responsible for the action of disulfiram as an aldehyde dehydrogenase inhibitor. This bioactivation process includes a reduction, an
Autor:
Morris D. Faiman, Bruce W. Hart
Publikováno v:
Biochemical Pharmacology. 46:2285-2290
Diethyldithiocarbamate (DDTC), diethyldithiocarbamate methyl ester (DDTC-Me), S-methyl N,N-diethylthiolcarbamate (DETC-Me) and S-methyl N,N-diethylthiolcarbamate sulfoxide (DETC-MeSO) are all metabolites of disulfiram. All inhibit rat liver low Km al
Autor:
Bruce W. Hart, Morris D. Faiman
Publikováno v:
Biochemical Pharmacology. 43:403-406
In summary, these data provide the first evidence that DETC-MeSO is a natural metabolite of disulfiram, and a potent inhibitor of rat liver mitochondrial low Km ALDH both in vitro and in vivo. It is therefore proposed that, based upon evidence to dat
Autor:
Jeffrey J. Yourick, Morris D. Faiman
Publikováno v:
Biochemical Pharmacology. 42:1361-1366
In humans and animals, disulfiram produces a disulfiram-ethanol reaction after an ethanol challenge, the basis of which is the inhibition of liver aldehyde dehydrogenase (ALDH). Disulfiram and the metabolites diethyldithiocarbamate (DDTC), diethyldit