Zobrazeno 1 - 10
of 206
pro vyhledávání: '"Michael S. Lawrence"'
Autor:
Krystle A. Lang Kuhs, Daniel L. Faden, Adam Langenbucher, Michael Cullen, James S. Lewis, Michael S. Lawrence, Mia Steinberg, Sara Bass, Joseph Boland, Robert L. Ferris, Lisa Mirabello, Meredith Yeager
Publikováno v:
Carcinogenesis
Human papillomavirus (HPV) positive oropharyngeal squamous cell carcinoma (HPV + OPSCC) is increasing in prevalence in the USA, as are cases of patients with multiple HPV + OPSCCs (mHPV + OPSCC). mHPV + OPSCCs present a unique opportunity to examine
Autor:
Kylie Prutisto Chang, Mari Mino-Kenudson, Alice T. Shaw, Adam Langenbucher, Michael S. Lawrence, Marina Kem, Pranav Gupta, Justin F. Gainor, Isobel J Fetter, Andrew Do, Satoshi Yoda, Jessica J. Lin, Ibiayi Dagogo-Jack, Audris Oh, Marguerite Rooney, Aaron N. Hata, James R. Stone, Ryan B. Corcoran, Emily Chin, Jochen K. Lennerz, Dejan Juric
Publikováno v:
npj Precision Oncology, Vol 4, Iss 1, Pp 1-8 (2020)
NPJ Precision Oncology
NPJ Precision Oncology
Histologic transformation from non-small cell to small cell lung cancer has been reported as a resistance mechanism to targeted therapy in EGFR-mutant and ALK fusion-positive lung cancers. Whether small cell transformation occurs in other oncogene-dr
Autor:
Michael S. Lawrence, Angela G. Fleischman, Kevin Aguirre, Shinho Park, Adam Langenbucher, Ryan B. Corcoran, Lee Zou, Danae Bowen, Pégah Jalili, Rémi Buisson
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Nature Communications
Nature communications, vol 11, iss 1
Nature Communications
Nature communications, vol 11, iss 1
APOBEC3A is a cytidine deaminase driving mutagenesis, DNA replication stress and DNA damage in cancer cells. While the APOBEC3A-induced vulnerability of cancers offers an opportunity for therapy, APOBEC3A protein and mRNA are difficult to quantify in
Autor:
Jian Jin, Fei Ji, Damayanti Chakraborty, Anqi Ma, Sweta Mishra, H. Ümit Kaniskan, Thomas L. Clarke, Ruslan I. Sadreyev, Michael S. Lawrence, Ran Tang, Capucine Van Rechem, Johnathan R. Whetstine
Publikováno v:
Cancer Discov
Acquired chromosomal DNA copy gains are a feature of many tumors; however, the mechanisms that underpin oncogene amplification are poorly understood. Recent studies have begun to uncover the importance of epigenetic states and histone lysine methyltr
Autor:
Benjamin Nicholson, Daniel A. Haber, David A. Sweetser, Shyamala Maheswaran, Min-Kyung Choo, Fei Ji, Douglas S. Micalizzi, Nicholas J. Haradhvala, Sooncheol Lee, Adam Langenbucher, Myriam Boukhali, Yasutaka Kato, David B. Sykes, Ruslan I. Sadreyev, Samuel S. Truesdell, Manuel D. Díaz-Muñoz, Roopali Gandhi, Syed I. A. Bukhari, Maria Antonietta Mazzola, Ipsita Dey-Guha, David T. Myers, Michael S. Lawrence, Dongjun Lee, Radhika Raheja, Shobha Vasudevan, Christopher Tiedje, Wilhelm Haas, Jennifer Lombardi-Story
Publikováno v:
Genome Biology, Vol 21, Iss 1, Pp 1-23 (2020)
Genome Biology
Lee, S, Micalizzi, D, Truesdell, S S, Bukhari, S I A, Boukhali, M, Lombardi-Story, J, Kato, Y, Choo, M K, Dey-Guha, I, Ji, F, Nicholson, B T, Myers, D T, Lee, D, Mazzola, M A, Raheja, R, Langenbucher, A, Haradhvala, N J, Lawrence, M S, Gandhi, R, Tiedje, C, Diaz-Muñoz, M D, Sweetser, D A, Sadreyev, R, Sykes, D, Haas, W, Haber, D A, Maheswaran, S & Vasudevan, S 2020, ' A post-transcriptional program of chemoresistance by AU-rich elements and TTP in quiescent leukemic cells ', Genome Biology, vol. 21, no. 1, 33 . https://doi.org/10.1186/s13059-020-1936-4
Genome Biology
Lee, S, Micalizzi, D, Truesdell, S S, Bukhari, S I A, Boukhali, M, Lombardi-Story, J, Kato, Y, Choo, M K, Dey-Guha, I, Ji, F, Nicholson, B T, Myers, D T, Lee, D, Mazzola, M A, Raheja, R, Langenbucher, A, Haradhvala, N J, Lawrence, M S, Gandhi, R, Tiedje, C, Diaz-Muñoz, M D, Sweetser, D A, Sadreyev, R, Sykes, D, Haas, W, Haber, D A, Maheswaran, S & Vasudevan, S 2020, ' A post-transcriptional program of chemoresistance by AU-rich elements and TTP in quiescent leukemic cells ', Genome Biology, vol. 21, no. 1, 33 . https://doi.org/10.1186/s13059-020-1936-4
Background Quiescence (G0) is a transient, cell cycle-arrested state. By entering G0, cancer cells survive unfavorable conditions such as chemotherapy and cause relapse. While G0 cells have been studied at the transcriptome level, how post-transcript
Autor:
Carlos Fernandez-del Castillo, Teppei Yamada, Linda T. Nieman, Chittampalli Yashaswini, Shyamala Maheswaran, Rebecca L. Porter, Vishal Thapar, Daniel A. Haber, Jeffrey A. Drebin, Gabriel Golczer, David P. Ryan, Michael S. Lawrence, David T. Ting, Tomohiro Kurokawa, Cristina R. Ferrone, Kevin D. Vo, Peter J. O'Dwyer, Alessandra Hillis, Annamaria Szabolcs, Anupriya S. Kulkarni, Abhijit Chougule, Theodore S. Hong, Robert Morris, Andrew S. Liss, Hongshan Guo, Neelima K.C. Magnus, Vikram Deshpande, Azfar Neyaz, Eric Tai, Matteo Ligorio
Publikováno v:
Proceedings of the National Academy of Sciences. 116:26835-26845
Transcriptional profiling has defined pancreatic ductal adenocarcinoma (PDAC) into distinct subtypes with the majority being classical epithelial (E) or quasi-mesenchymal (QM). Despite clear differences in clinical behavior, growing evidence indicate
Autor:
Ashok S. Bhagwat, Ramin Sakhtemani, Vimukthi Senevirathne, Roger Pique-Regi, Jessica A. Stewart, Madusha L. W. Perera, Michael S. Lawrence
Publikováno v:
J Biol Chem
Activation-induced deaminase (AID) and apolipoprotein B mRNA-editing enzyme catalytic subunit (APOBEC) enzymes convert cytosines to uracils, creating signature mutations that have been used to predict sites targeted by these enzymes. Mutation-based t
Autor:
Adam Langenbucher, Siang-Boon Koh, Hope S. Rugo, Erica L. Mayer, Lisa A. Carey, Srinivas Vinod Saladi, Lei He, Tiffany A. Traina, Steven J. Isakoff, Vered Stearns, Minetta C. Liu, Michael S. Lawrence, Sridhar Ramaswamy, Nsan Melkonjan, Andrew Schultz, Leif W. Ellisen, Kenneth N. Ross, Karina J. Matissek
Publikováno v:
Koh, S-B, Ross, K, Isakoff, S J, Melkonjan, N, He, L, Matissek, K J, Schultz, A, Mayer, E L, Traina, T A, Carey, L A, Rugo, H S, Liu, M C, Stearns, V, Langenbucher, A, Saladi, S V, Ramaswamy, S, Lawrence, M S & Ellisen, L W 2021, ' RASAL2 Confers Collateral MEK/EGFR Dependency in Chemoresistant Triple-Negative Breast Cancer ', Clinical Cancer Research, vol. 27, no. 17, pp. 4883-4897 . https://doi.org/10.1158/1078-0432.CCR-21-0714
Clin Cancer Res
Clin Cancer Res
Purpose: While chemotherapy remains the standard treatment for triple-negative breast cancer (TNBC), identifying and managing chemoresistant tumors has proven elusive. We sought to discover hallmarks and therapeutically actionable features of refract
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47d584ccaf68267da9eb08c33d1fb8ce
https://research-information.bris.ac.uk/en/publications/1e9956ee-f86f-422d-82c9-c3c9149c2fe8
https://research-information.bris.ac.uk/en/publications/1e9956ee-f86f-422d-82c9-c3c9149c2fe8
Autor:
Krystle A. Lang Kuhs, Michael Cullen, Mia Steinberg, Maisa Pinheiro, Sara Bass, James S. Lewis, Michael S. Lawrence, Daniel L. Faden, Maoxuan Lin, Adam Langenbucher, Meredith Yeager, Joseph Boland, Lisa Mirabello, Robert L. Ferris
Publikováno v:
Viruses, Vol 13, Iss 1666, p 1666 (2021)
Viruses
Volume 13
Issue 8
Viruses
Volume 13
Issue 8
APOBEC (apolipoprotein B mRNA-editing enzyme, catalytic polypeptide-like) is a major mutagenic source in human papillomavirus positive oropharyngeal squamous cell carcinoma (HPV+ OPSCC). Why APOBEC mutations predominate in HPV+OPSCC remains an area o
Autor:
Elad Horwitz, Joanna A. Vuille, Ben S. Wittner, Devon F. Wiley, Xin Hong, Taronish D. Dubash, Shyamala Maheswaran, Kira L. Niederhoffer, Soroush Hajizadeh, Michael S. Lawrence, Shobha Vasudevan, Risa Burr, Linda T. Nieman, Uyen Ho, Adam Langenbucher, Raul Mostoslavsky, Lee Zou, Benjamin Wesley, Richard Y. Ebright, Jia-Min Zhang, Hongshan Guo, Chenyue Lu, Valentine Comaills, Marcus A. Zachariah, Daniel A. Haber, Gabriel Golczer, Brittany A. Reeves, Mehmet Toner
Publikováno v:
Mol Cell
Summary Deregulation of oncogenic signals in cancer triggers replication stress. Immediate early genes (IEGs) are rapidly and transiently expressed following stressful signals, contributing to an integrated response. Here, we find that the orphan nuc