Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Medha Priyadarshini"'
Autor:
Wasim Khan, Pauline M. Maki, Barton Wicksteed, Anukriti Sharma, Brian T. Layden, Kai Xu, George E. Chlipala, Christopher R. Manzella, Beatriz Penalver Bernabe, Yang Dai, Kristen Lednovich, Ravinder K. Gill, Guadalupe Navarro, Jack A. Gilbert, Barbara Sanzyal, Medha Priyadarshini, Derek Reiman
Background and aimsNormal gestation involves reprogramming of maternal gut microbiome (GM) that may contribute to maternal metabolic changes by unclear mechanisms. This study aimed to understand the mechanistic underpinnings of GM – maternal metabo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3a208c3a4d648dbcb475c35b96779038
https://doi.org/10.1101/2021.07.21.453234
https://doi.org/10.1101/2021.07.21.453234
Autor:
Medha Priyadarshini, Sophie Gough, Barton Wicksteed, Brian T. Layden, Kai Xu, Kristen Lednovich
Publikováno v:
Metabolites, Vol 11, Iss 302, p 302 (2021)
Metabolites
Metabolites
The gut microbiome has emerged as a novel determinant of type 1 diabetes (T1D), but the underlying mechanisms are unknown. In this context, major gut microbial metabolites, short-chain fatty acids (SCFAs), are considered to be an important link betwe
Autor:
Weiran Zhang, Nan Wang, Medha Priyadarshini, Jose Cordoba-Chacon, Brian T. Layden, Kenta Kuramoto, Congcong He, Soh Yamamoto, Xiaolei Situ
Publikováno v:
Cell Reports, Vol 23, Iss 11, Pp 3286-3299 (2018)
Summary: Autophagy, a stress-induced lysosomal degradative pathway, has been assumed to exert similar metabolic effects in different organs. Here, we establish a model where autophagy plays different roles in insulin-producing β cells versus insulin
Autor:
Brian T. Layden, Medha Priyadarshini, Lara R. Dugas, George E. Chlipala, Stefan J. Green, Yuval Eisenberg, Elena Barengolts
Publikováno v:
Microorganisms
Volume 7
Issue 9
Microorganisms, Vol 7, Iss 9, p 320 (2019)
Volume 7
Issue 9
Microorganisms, Vol 7, Iss 9, p 320 (2019)
Gut microbiota and their biomarkers may be associated with obesity. This study evaluated associations of body mass index (BMI) with circulating microbiota biomarkers in African American men (AAM) (n = 75). The main outcomes included fecal microbial c
Publikováno v:
Endocrinology. 159:2495-2505
The G protein–coupled receptors, free fatty acid (FFA) receptors 2 and 3 (FFA2 and FFA3), belonging to the free fatty acid receptor (FFAR) class, sense a distinct class of nutrients, short chain fatty acids (SCFAs). These receptors participate in b
Autor:
Annette Gilchrist, Stephanie R. Villa, Rama K. Mishra, Gary E. Schiltz, Medha Priyadarshini, Joseph L. Zapater, Helena Mancebo, Brian T. Layden
Publikováno v:
Journal of Investigative Medicine. 65:1116-1124
Critical aspects of maintaining glucose homeostasis in the face of chronic insulin resistance and type 2 diabetes (T2D) are increased insulin secretion and adaptive expansion of beta cell mass. Nutrient and hormone sensing G protein-coupled receptors
Publikováno v:
Trends in Endocrinology & Metabolism. 27:653-664
Nutrient sensing receptors are key metabolic mediators of responses to dietary and endogenously derived nutrients. These receptors are largely G-protein coupled receptors (GPCRs) and many are gaining significant interest as drug targets with a potent
Autor:
Xiang Gao, David E. Nelson, Brian T. Layden, Lara R. Dugas, Neil Gottel, Jacob Plange-Rhule, Laquita Brown, Stephanie Kliethermes, Evelyn Toh, Jack A. Gilbert, Medha Priyadarshini, Amy Luke, Beatriz Penalver Bernabe, Jun Sun, Seo J. Park, Na Fei, Qunfeng Dong
Publikováno v:
Scientific Reports
Scientific reports, vol 8, iss 1
Scientific Reports, Vol 8, Iss 1, Pp 1-17 (2018)
Scientific reports, vol 8, iss 1
Scientific Reports, Vol 8, Iss 1, Pp 1-17 (2018)
We compared the gut microbial populations in 100 women, from rural Ghana and urban US [50% lean (BMI 2) and 50% obese (BMI ≥ 30 kg/m2)] to examine the ecological co-occurrence network topology of the gut microbiota as well as the relationship of sh
Autor:
William L. Lowe, Brian T. Layden, Anthony R. Angueira, Medha Priyadarshini, Timothy E. Reddy, Xianzhong Ding, Guang Yu Yang, Amy C. Y. Lo, Cong Guo, Korri S. Hershenhouse, Anton E. Ludvik, Carolina M. Pusec
Publikováno v:
Endocrinology. 157:3452-3461
In a recent genome-wide association study, hexokinase domain-containing protein 1, or HKDC1, was found to be associated with gestational glucose levels during 2-hour glucose tolerance tests at 28 weeks of pregnancy. Because our understanding of the m
Autor:
Jack A. Gilbert, Medha Priyadarshini, Fredrik Bäckhed, Miles Fuller, Michael R. Brodsky, William L. Lowe, Sean M. Gibbons, Petia Kovatcheva-Datchary, M. Geoffrey Hayes, Anthony R. Angueira, Brian T. Layden
Publikováno v:
American Journal of Physiology-Endocrinology and Metabolism. 309:E840-E851
The structure of the human gastrointestinal microbiota can change during pregnancy, which may influence gestational metabolism; however, a mechanism of action remains unclear. Here we observed that in wild-type (WT) mice the relative abundance of Act