Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Lourdes Hontecillas-Prieto"'
Autor:
María José Robles, Jaume Mora, Enrique de Álava, Eduardo Andrés-León, Ana M. Espinosa-Oliva, Nabil Hajji, Laura Carmen Terrón-Camero, Daniel J. García-Domínguez, Sara Sanchez-Molina, Rocío Flores-Campos, Lourdes Hontecillas-Prieto, Elisabet Figuerola, Angel M. Carcaboso, Guillem Pascual-Pasto, Rocío M. de Pablos
Ewing sarcoma (EWS) is an aggressive developmental sarcoma driven by a fusion gene, EWSR1-FLI1. However, little is known about the regulation of EWSR1-FLI1 chimeric fusion gene expression. Here, we demonstrate that active nuclear HDAC6 in EWS modulat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::caa4d84ef9066159a6bd539f0101349f
https://doi.org/10.1101/2021.01.04.425179
https://doi.org/10.1101/2021.01.04.425179
Autor:
Jaume Mora, María José Robles, Nabil Hajji, Antonio Llombart-Bosch, Ana M. Espinosa-Oliva, Katia Scotlandi, Giovanna Magagnoli, Rocío M. de Pablos, Angel M. Carcaboso, Eduardo Andrés-León, Laura Carmen Terrón-Camero, Daniel J. García-Domínguez, Sara Sanchez-Molina, Elisabet Figuerola-Bou, Rocío Flores-Campos, Lourdes Hontecillas-Prieto, Enrique de Álava, Isidro Machado, Guillem Pascual-Pasto
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
instname
idUS. Depósito de Investigación de la Universidad de Sevilla
Oncogene
Digital.CSIC: Repositorio Institucional del CSIC
Consejo Superior de Investigaciones Científicas (CSIC)
instname
idUS. Depósito de Investigación de la Universidad de Sevilla
Oncogene
Digital.CSIC: Repositorio Institucional del CSIC
Consejo Superior de Investigaciones Científicas (CSIC)
Ewing sarcoma (EWS) is an aggressive bone and soft tissue tumor of children and young adults in which the principal driver is a fusion gene, EWSR1-FLI1. Although the essential role of EWSR1-FLI1 protein in the regulation of oncogenesis, survival, and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee53179db5ed069d220b3c0195f53a99
http://hdl.handle.net/10261/247260
http://hdl.handle.net/10261/247260
Autor:
Lourdes Hontecillas-Prieto, Eduardo Andres Leon, Enrique de Álava, Francisco J. Morón, Carlos Mackintosh, Daniel J. García-Domínguez, Nabil Hajji, Pablo Rodríguez-Núñez, Sara Sanchez-Molina
Publikováno v:
PLoS ONE
Digital.CSIC. Repositorio Institucional del CSIC
instname
PLoS ONE, Vol 15, Iss 6, p e0234243 (2020)
Digital.CSIC. Repositorio Institucional del CSIC
instname
PLoS ONE, Vol 15, Iss 6, p e0234243 (2020)
The presence of the chimeric EWSR1-FLI1 oncoprotein is the main and initiating event defining Ewing sarcoma (ES). The dysregulation of epigenomic and proteomic homeostasis induced by the oncoprotein contributes to a wide variety of events involved in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c24937352f17cd30c554b0f8891b778d
Autor:
Daniel J. García-Domínguez, María Sánchez-Jiménez, Enrique de Álava, Oscar M. Tirado, Jaume Mora, Elisabet Figuerola-Bou, Inmaculada Hernández-Muñoz, Estela Prada, Sara Sanchez-Molina, Angel M. Carcaboso, Lourdes Hontecillas-Prieto, Cinzia Lavarino, Pablo Táboas, Enrique Blanco, Cecilia Ballaré, Luciano Di Croce, Soledad Gómez
Publikováno v:
Science Advances
Dipòsit Digital de la UB
Universidad de Barcelona
Digital.CSIC. Repositorio Institucional del CSIC
instname
Dipòsit Digital de la UB
Universidad de Barcelona
Digital.CSIC. Repositorio Institucional del CSIC
instname
Ewing sarcoma (EwS) is an aggressive tumor that affects adolescents and young adults. EwS is defined by a chromosomal translocation, EWSR1-FLI1 being the most common, that causes genome reprogramming through remodeling of enhancers. Here, we describe
Autor:
María José Robles, Enrique de Álava, Pablo Rodríguez-Núñez, Daniel J. García-Domínguez, Guillem Pascual-Pasto, Oscar M. Tirado, Jaume Mora, Angel M. Carcaboso, Monica Vila-Ubach, Lourdes Hontecillas-Prieto, Rosa Garcia-Mejias
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
instname
Oncotarget
instname
Oncotarget
[Purpose] Epigenetic regulation is crucial in mammalian development and maintenance of tissue-cell specific functions. Perturbation of epigenetic balance may lead to alterations in gene expression, resulting in cellular transformation and malignancy.
Autor:
Santi Rello-Varona, Olga Almacellas-Rabaiget, Roser López-Alemany, Jaume Mora, Piedad Alba-Pavón, Enrique de Álava, Juan Huertas-Martinez, Lourdes Hontecillas-Prieto, Silvia Garcia-Monclús, David Herrero-Martin, Laura Lagares-Tena, Paloma H. Giangrande, O.M. Tirado
Publikováno v:
International Journal of Cancer. 143:1188-1201
Ewing sarcoma (ES) is the second most common bone malignancy affecting children and young adults with poor prognosis due to high metastasis incidence. Our group previously described that EphA2, a tyrosine kinase receptor, promotes angiogenesis in Ewi
Autor:
Gema L. Ramírez-Villar, Lourdes Hontecillas-Prieto, Daniel J. García-Domínguez, Carmen Sáez, de Álava E, Rosa Garcia-Mejias
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
instname
idUS. Depósito de Investigación de la Universidad de Sevilla
idUS: Depósito de Investigación de la Universidad de Sevilla
Universidad de Sevilla (US)
Oncotarget
instname
idUS. Depósito de Investigación de la Universidad de Sevilla
idUS: Depósito de Investigación de la Universidad de Sevilla
Universidad de Sevilla (US)
Oncotarget
Wilms tumor (WT) is an embryonal malignant neoplasm of the kidney that accounts for 6–7% of all childhood cancers. WT seems to derive from multipotent embryonic renal stem cells that have failed to differentiate properly. Since mechanisms underlyin
Autor:
Enrique de Álava, Nelofer Syed, Daniel J. García-Domínguez, Nabil Hajji, Lourdes Hontecillas-Prieto, Kevin O’Neill
Publikováno v:
Epigenomics. 13(5)
One of the major obstacles to the development of effective new cancer treatments and the main factor for the increasing number of clinical trial failures appears to be the paucity of accurate, reproducible and robust drug resistance testing methods.
Autor:
Jaume Mora, Enrique de Álava, Soledad Gallego, Paloma H. Giangrande, Xavier Garcia del Muro, Oscar M. Tirado, Manel Esteller, Silvia Garcia-Monclús, Laura Lagares-Tena, Xavier Sanjuan, Miguel Sáinz-Jaspeado, David Herrero-Martin, Josep Roma, Lourdes Hontecillas-Prieto, Ana Sastre, Dave Monk, Olga Almacellas-Rabaiget, Juan Huertas-Martinez, Santiago Rello-Varona, Franck Court, M A Peinado, Raquel Buj, Sebastian Moran, Javier Alonso, Roser López-Alemany, Daniel Azorín
Publikováno v:
Cancer Letters
r-IGTP. Repositorio Institucional de Producción Científica del Instituto de Investigación Germans Trias i Pujol
instname
CANCER LETTERS
r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
r-FSJD: Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
Fundació Sant Joan de Déu
r-IGTP. Repositorio Institucional de Producción Científica del Instituto de Investigación Germans Trias i Pujol
instname
CANCER LETTERS
r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
r-FSJD: Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
Fundació Sant Joan de Déu
Epigenetic modifications have been shown to be important in developmental tumors as Ewing sarcoma. We profiled the DNA methylation status of 15 primary tumors, 7 cell lines, 10 healthy tissues and 4 human mesenchymal stem cells lines samples using th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ffdadcddcf90374673ff7eda919bc27
https://fundanet.igtp.cat/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=6141
https://fundanet.igtp.cat/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=6141
Autor:
María del Mar Sáez-Freire, Jesús Pérez-Losada, Lourdes Hontecillas-Prieto, Andrés Castellanos-Martín, Jian-Hua Mao, Adrián Blanco-Gómez, Sonia Castillo-Lluva
Publikováno v:
Blanco-Gómez, A; Castillo-Lluva, S; del Mar Sáez-Freire, M; Hontecillas-Prieto, L; Mao, JH; Castellanos-Martín, A; et al.(2016). Missing heritability of complex diseases: Enlightenment by genetic variants from intermediate phenotypes. BioEssays, 38(7), 664-673. doi: 10.1002/bies.201600084. Lawrence Berkeley National Laboratory: Retrieved from: http://www.escholarship.org/uc/item/10j0m1gv
BioEssays : news and reviews in molecular, cellular and developmental biology, vol 38, iss 7
Digital.CSIC. Repositorio Institucional del CSIC
instname
BioEssays : news and reviews in molecular, cellular and developmental biology, vol 38, iss 7
Digital.CSIC. Repositorio Institucional del CSIC
instname
Diseases of complex origin have a component of quantitative genetics that contributes to their susceptibility and phenotypic variability. However, after several studies, a major part of the genetic component of complex phenotypes has still not been f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1838883fdb9104ff0027733301d8c8e3
http://www.escholarship.org/uc/item/10j0m1gv
http://www.escholarship.org/uc/item/10j0m1gv