Zobrazeno 1 - 10
of 133
pro vyhledávání: '"Leon J. Schurgers"'
Autor:
Marion J.J. Gijbels, Judith C. Sluimer, Ulf Hedin, Christoph Kuppe, J. De Bruijn, Thomas L. Theelen, Javier Perales-Patón, Rafael Kramann, Peter Carmeliet, Barend Mees, Leon J. Schurgers, Chris P. M. Reutelingsperger, E. Biessen, Elke Marsch, Andrew H. Baker, Jasper A. F. Demandt, Han Jin, Julio Saez-Rodriguez, K. van Kuijk, Ljubica Perisic Matic
Publikováno v:
Cardiovascular Research, 118(5), 1232-1246
Cardiovascular Research, 118(5), 1232-1246. Oxford University Press
Cardiovascular Research, 118(5), 1232-1246. Oxford University Press
AIMS: Atherosclerotic plaque hypoxia is detrimental for macrophage function. Prolyl hydroxylases (PHDs) initiate cellular hypoxic responses, possibly influencing macrophage function in plaque hypoxia. Thus, we aimed to elucidate the role of myeloid P
Autor:
Rafael Kramann, Marjolein M. J. Caron, Bert van Rietbergen, Peter Leenders, Selene Prisco, Jürgen Floege, Tim J. M. Welting, Marc G. Vervloet, Grzegorz B. Wasilewski, Leon J. Schurgers, Aegida Neradova
Publikováno v:
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association-European Renal Association, 37(4), 652-662. Oxford University Press
Nephrology Dialysis Transplantation, 37(4), 652-662. Oxford University Press
Neradova, A, Wasilewski, G, Prisco, S, Leenders, P, Caron, M, Welting, T, van Rietbergen, B, Kramann, R, Floege, J R, Vervloet, M G & Schurgers, L J 2022, ' Combining phosphate binder therapy with vitamin K2 inhibits vascular calcification in an experimental animal model of kidney failure ', Nephrology Dialysis Transplantation, vol. 37, no. 4, pp. 652-662 . https://doi.org/10.1093/ndt/gfab314
Nephrology Dialysis Transplantation, 37(4), 652-662. Oxford University Press
Neradova, A, Wasilewski, G, Prisco, S, Leenders, P, Caron, M, Welting, T, van Rietbergen, B, Kramann, R, Floege, J R, Vervloet, M G & Schurgers, L J 2022, ' Combining phosphate binder therapy with vitamin K2 inhibits vascular calcification in an experimental animal model of kidney failure ', Nephrology Dialysis Transplantation, vol. 37, no. 4, pp. 652-662 . https://doi.org/10.1093/ndt/gfab314
Background Hyperphosphataemia is strongly associated with cardiovascular disease and mortality. Recently, phosphate binders (PBs), which are used to bind intestinal phosphate, have been shown to bind vitamin K, thereby potentially aggravating vitamin
Autor:
Nazanin Kabgani, Felix Schreibing, Leon J. Schurgers, Jürgen Floege, Thimoteus Speer, Vera Jankowski, Christoph Kuppe, Christiane Drechsler, Peter Boor, Rafael Kramann, Sofia de la Puente-Secades, Nikolas Rapp, Nadine Kaesler
Publikováno v:
Kidney International, 101(2), 338-348. Elsevier Inc.
Kidney International, 101(2), 338-348. Elsevier Science
Kidney International, 101(2), 338-348. Elsevier Science
Chronic kidney disease (CKD) is accompanied with extensive cardiovascular calcification, in part correlating with functional vitamin K deficiency. Here, we sought to determine causes for vitamin K deficiency beyond reduced dietary intake. Initially,
Publikováno v:
Kidney International. 100:1023-1036
Vitamin K, well known for its role in coagulation, encompasses 2 major subgroups: vitamin K1 is exclusively synthesized by plants, whereas vitamin K2 mostly originates from bacterial synthesis. Vitamin K serves as a cofactor for the enzyme gamma-glut
Autor:
Marc R. Dweck, Danyel Jennen, Matthias Bauwens, Rick H. van Gorp, Joanne van Ryn, Jan Bucerius, Vincent Brandenburg, Ingrid Dijkgraaf, Felix M. Mottaghy, Chris P. M. Reutelingsperger, Peter Leenders, Jacco J. Briedé, Leon J. Schurgers, Vanessa Bröker, Henri M. H. Spronk
Publikováno v:
Journal of Thrombosis and Haemostasis, 19(5), 1348-1363. Wiley
Journal of Thrombosis and Haemostasis
Journal of Thrombosis and Haemostasis
INTRODUCTION: Vitamin K antagonists (VKA) and non-vitamin K oral antagonist anticoagulants (NOAC) are used in the clinic to reduce risk of thrombosis. However, they also exhibit vascular off-target effects. The aim of this study is to compare VKA and
Autor:
Lyanne M. Kieneker, Ron T. Gansevoort, Martin H. de Borst, Joline W. J. Beulens, Adriana J. van Ballegooijen, Marc Vervloet, Leon J. Schurgers, Ido P. Kema, Stephan J. L. Bakker
Publikováno v:
European Journal of Nutrition
European Journal of Nutrition, 60. SPRINGER HEIDELBERG
van Ballegooijen, A J, Beulens, J W J, Kieneker, L M, de Borst, M H, Gansevoort, R T, Kema, I P, Schurgers, L J, Vervloet, M G & Bakker, S J L 2021, ' Combined low vitamin D and K status amplifies mortality risk : a prospective study ', European Journal of Nutrition, vol. 60, no. 3, pp. 1645-1654 . https://doi.org/10.1007/s00394-020-02352-8
European Journal of Nutrition, 60(3), 1645-1654. D. Steinkopff-Verlag
European Journal of Nutrition, 60(3), 1645-1654. Springer
European Journal of Nutrition, 60. SPRINGER HEIDELBERG
van Ballegooijen, A J, Beulens, J W J, Kieneker, L M, de Borst, M H, Gansevoort, R T, Kema, I P, Schurgers, L J, Vervloet, M G & Bakker, S J L 2021, ' Combined low vitamin D and K status amplifies mortality risk : a prospective study ', European Journal of Nutrition, vol. 60, no. 3, pp. 1645-1654 . https://doi.org/10.1007/s00394-020-02352-8
European Journal of Nutrition, 60(3), 1645-1654. D. Steinkopff-Verlag
European Journal of Nutrition, 60(3), 1645-1654. Springer
Objective To explore the association of both plasma vitamin D and K concentrations with all-cause mortality, cardiovascular mortality, and cardiovascular events in the general population. Methods We studied 4742 participants of the Prevention of REna
Autor:
Anas M. Saad, Essa Hariri, Jean-Pierre Iskandar, Samir R. Kapadia, Serge C. Harb, Agam Bansal, Leon J. Schurgers, Toshiaki Isogai, Omar M Abdelfattah, Nicholas Kassis
Publikováno v:
Open Heart, Vol 8, Iss 2 (2021)
Vitamin K2 serves an important role in cardiovascular health through regulation of calcium homeostasis. Its effects on the cardiovascular system are mediated through activation of the anti-calcific protein known as matrix Gla protein. In its inactive
Autor:
Jona Walk, Henny van Daal, Petra Lux, Jody M. W. van den Ouweland, Pim A. de Jong, Esther G.A. Karssemeijer, Emiel F.M. Wouters, Rob Janssen, Reinoud Gosens, Loes E. M. Kistemaker, Cecile Maassen, Leon J. Schurgers, Anton S M Dofferhoff, Ianthe Piscaer, Cees Vermeer, Tilman M. Hackeng, Margot P. J. Visser
Publikováno v:
Clinical Infectious Diseases, 73, e4039-e4046
Clinical Infectious Diseases, 73, 11, pp. e4039-e4046
Clinical Infectious Diseases, 73(11). Oxford University Press
Clinical Infectious Diseases, 73(11), E4039-E4046. Oxford University Press
Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
Clinical Infectious Diseases
Clinical Infectious Diseases, 73, 11, pp. e4039-e4046
Clinical Infectious Diseases, 73(11). Oxford University Press
Clinical Infectious Diseases, 73(11), E4039-E4046. Oxford University Press
Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
Clinical Infectious Diseases
Background Respiratory failure and thromboembolism are frequent in severe acute respiratory syndrome coronavirus 2–infected patients. Vitamin K activates both hepatic coagulation factors and extrahepatic endothelial anticoagulant protein S, require
Autor:
Hannes Olauson, Pieter Evenepoel, Lu Dai, Abdul Rashid Qureshi, Leon J. Schurgers, Jonaz Ripsweden, Peter Stenvinkel, Anna Witasp, Armand M. G. Jaminon, Magnus Söderberg
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-9 (2020)
Scientific Reports
Scientific Reports, 10(1):6586. Nature Publishing Group
Scientific Reports
Scientific Reports, 10(1):6586. Nature Publishing Group
Matrix Gla protein (MGP) is a potent inhibitor of vascular calcification (VC) and requires carboxylation by vitamin K to exert calcification inhibition. Chronic kidney disease (CKD) patients undergo early vascular aging often involving extensive VC.
Autor:
Adrian Post, Stefan P Berger, Tim J Knobbe, Charlotte A. Keyzer, Coby Eelderink, Stephan J. L. Bakker, Leon J. Schurgers, Dion Groothof, TransplantLines Investigators, Michele F Eisenga, Martin H. de Borst, Marco van Londen, Daan Kremer
Publikováno v:
Nutrients, 13(9):3069. MDPI AG
Nutrients
Volume 13
Issue 9
Nutrients, 13(9):3069. Multidisciplinary Digital Publishing Institute (MDPI)
Nutrients, Vol 13, Iss 3069, p 3069 (2021)
Nutrients
Volume 13
Issue 9
Nutrients, 13(9):3069. Multidisciplinary Digital Publishing Institute (MDPI)
Nutrients, Vol 13, Iss 3069, p 3069 (2021)
High circulating dephosphorylated (dp) uncarboxylated (uc) matrix Gla protein (MGP) and uc osteocalcin (OC) concentrations are regarded as markers of vitamin K-deficiency. However, because MGP and OC are small molecules, they may potentially pass the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81290e52c2a1dd36e8500026ab553cde
https://research.rug.nl/en/publications/5243fad9-ba78-4a92-b356-4fff52744ba1
https://research.rug.nl/en/publications/5243fad9-ba78-4a92-b356-4fff52744ba1