Zobrazeno 1 - 10
of 159
pro vyhledávání: '"Lang Chen"'
Autor:
Chen Cheng, Linxiao Hou, Xudong Fu, Yuqing Zhu, Lang Chen, Li Zhang, Kuan Yoow Chan, Jin Zhang, Zhen Sun, Hongru Pan, Ling Zhang
Publikováno v:
Stem Cell Reports
Summary Mouse embryonic stem cells (ESCs) show cell-to-cell heterogeneity. A small number of two-cell-like cells (2CLCs) marked by endogenous retrovirus activation emerge spontaneously. The 2CLCs are unstable and they are prone to transiting back to
Autor:
Cheng Li, Ling Zhang, Lang Chen, Hongru Pan, Jiayu Chen, Zhen Sun, Yuyan Xu, Ming Chen, Pengxu Qian, Yuqing Zhu, George Q. Daley, Tianyu Tan, Zhengping Xu, Jinghao Sheng, Shaorong Gao, Jin Zhang, Anhua Lei, Hua Yu, Jing Zhao, Yaxin Liu
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-21 (2021)
Nature Communications
Nature Communications
The nucleolus is the organelle for ribosome biogenesis and sensing various types of stress. However, its role in regulating stem cell fate remains unclear. Here, we present evidence that nucleolar stress induced by interfering rRNA biogenesis can dri
Autor:
Chao-Lang Chen, Yan-Wei Lin, Kuo-Chen Wei, Yu-Chuan Liu, Ying Ling Chen, Yu Jie Chen, Chi-Han Chiu, Ying-Zu Huang, Hung Li Wang, Chia Chen Hsu, Chin-Song Lu, Ching Chi Chiu, Tu-Hsueh Yeh, Yi-Hsin Weng, Rou-Shayn Chen
Publikováno v:
Neurobiology of Aging. 107:189-196
Our previous study suggests that upregulated RAB35 is implicated in etiology of Parkinson's disease (PD). We hypothesized that upregulated RAB35 results from single nucleotide polymorphisms (SNPs) in RAB35 gene promoter. We identified SNPs within RAB
Autor:
Yuli Qian, Da-Wei Lin, Jing Zhao, Ling Zhang, Hu Li, Hua Yu, Wei Xie, Jin Zhang, Yuyan Xu, Min Zhang, Shuyan Ji, Lang Chen, Zeping Hu, Zhen Sun, Dan Zhang, Cristina Correia, Hongru Pan, Taylor M. Weiskittel, Xudong Fu, Yuzheng Zhao, Sriram Chandrasekaran, Jie Chen, Yuqing Zhu, Ke Yao, Cheng Zhang, Heng-Yu Fan
Publikováno v:
Nature Metabolism. 3:1372-1384
During early mammalian embryogenesis, changes in cell growth and proliferation depend on strict genetic and metabolic instructions. However, our understanding of metabolic reprogramming and its influence on epigenetic regulation in early embryo devel
Autor:
Xin Liu, Motao Zhu, Lang Chen, Changsheng Xing, Chen Qian, Chaoran Li, Helen Yicheng Wang, Chuntang Fu, Guangtong Deng, Rongfu Wang
Publikováno v:
Autophagy
Macroautophagy/autophagy-related proteins regulate infectious and inflammatory diseases in autophagy-dependent or -independent manner. However, the role of a newly identified mammalian-specific autophagy protein-BECN2 (beclin 2) in innate immune regu
Autor:
Riping Zhang, Shao-Lang Chen, Shaowan Chen, Geng Wang, Tsz Kin Ng, Lixia Sun, Kunliang Qiu, Yanxuan Xu, Yuqian Zheng, Xiang-Ling Yuan
Publikováno v:
Ophthalmic Genetics. 42:446-457
Background: Myopia is the most prevalent ocular disorder in the world, and corneal parameters have been regarded as key ocular biometric parameters determining the refractive status. Here, we aimed to determine the association of genome-wide associat
Publikováno v:
Journal of Molecular Neuroscience. 71:1838-1848
The occurrence of ischemia-reperfusion (I/R) injury leads to dysfunction as well as high rates of morbidity and mortality in stroke, and new effective therapeutic strategies for I/R are still needed. We investigated the effect of IL-27 on I/R injury-
Autor:
Shao-Lang Chen, Yingjie Cao, Shaowan Chen, Xiang-Ling Yuan, Haoyu Chen, Yanxuan Xu, Tsz Kin Ng, Yuqian Zheng
Publikováno v:
Eye (Lond)
Objectives To delineate the disease-causing mutations of the Stargardt disease-related genes in Chinese patients diagnosed with Stargardt disease or retinitis pigmentosa (RP) by whole exome sequencing analysis. Methods A total of 123 sporadic RP or S
Publikováno v:
Virol Sin
Human immunodeficiency virus (HIV) attacks human immune system and causes life-threatening acquired immune deficiency syndrome (AIDS). Treatment with combination antiretroviral therapy (cART) could inhibit virus growth and slow progression of the dis
Autor:
Xin Luo, Jingxue Xin, Xuebin Qi, Zhanying Feng, Hui Zhang, Qiuyue Yuan, Wing Hung Wong, Yaoxi He, Lang Chen, Zhana Duren, Caijuan Bai, Yong Wang, Chaoyu Zhang, Ouzhuluobu, Dong Sheng Yan, Xiang Zhu, Chaoying Cui, Bing Su
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-20 (2020)
Nature Communications
Nature Communications
High-altitude adaptation of Tibetans represents a remarkable case of natural selection during recent human evolution. Previous genome-wide scans found many non-coding variants under selection, suggesting a pressing need to understand the functional r