Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Jun-ichi Iga"'
Autor:
Hiroshi Kumon, Yu Funahashi, Takaaki Mori, Yuki Ozaki, Shinichiro Ochi, Yuta Yoshino, Kiyohiro Yamazaki, Shu-ichi Ueno, Jun-ichi Iga, Hiroaki Mori
Publikováno v:
Molecular Neurobiology
The testing of pathological biomarkers of Alzheimer’s disease (AD), such as amyloid beta and tau, is time-consuming, expensive, and invasive. Here, we used 3xTg-AD mice to identify and validate putative novel blood transcriptome biomarkers of AD th
Autor:
Kentaro Kawabe, Tomomasa Ibuki, Kiyohiro Yamazaki, Shinichiro Ochi, Yoko Mori, Yuki Ozaki, Yuta Yoshino, Jun-ichi Iga, Tetsuro Ohmori, Shu-ichi Ueno, Shusuke Numata
Publikováno v:
Neuropsychiatric Disease and Treatment. 16:441-446
Introduction: Although ATP-binding cassette sub-family A member 7 gene (ABCA7) is known to be associated with Alzheimer’s disease, the relationship between ABCA7 and schizophrenia has been unknown. Methods: Schizophrenia patients (n = 50; 24 males,
Autor:
Ayumi Tachibana, Yuta Yoshino, Hiroshi Kumon, Taku Yoshida, Takaaki Mori, Hideaki Shimizu, Shu-ichi Ueno, Jun-ichi Iga
Publikováno v:
BMC Genomics
BMC Genomics, Vol 22, Iss 1, Pp 1-10 (2021)
BMC Genomics, Vol 22, Iss 1, Pp 1-10 (2021)
Background Alanine:glyoxylate aminotransferase 2 (AGXT2; EC 2.6.1.44) is the only enzyme that degrades the R-form of 3-aminoisobutyrate, an intermediate metabolite of thymine. AGXT2, as well as diaminoarginine dimethylaminohydrolase 1 (DDAH1; EC 3.5.
Autor:
Hiroshi Kumon, Naoki Abe, Jun-ichi Iga, Shuken Boku, Keisuke Sekiya, Shu-ichi Ueno, Tasuku Nishihara, Yuta Yoshino, Yu Funahashi, Shinichiro Ochi
Publikováno v:
Scientific Reports
Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
The pathophysiology of delayed carbon monoxide (CO) encephalopathy remains unclear. In this study, the effects of CO exposure on the dentate gyrus (DG) were investigated in a Wistar rat model by histochemical and molecular methods. Model rats showed
Autor:
Shinichiro Ochi, Taku Yoshida, Tomoko Sao, Yoko Mori, Jun-ichi Iga, Takaaki Mori, Kiyohiro Yamazaki, Yuta Yoshino, Yuki Ozaki, Shu-ichi Ueno
Publikováno v:
Journal of Psychiatric Research. 92:74-80
Recent genome-wide association studies revealed that Triggering receptor expressed on myeloid cells 2 (TREM2) was associated with Alzheimer's disease (AD) and other neurodegenerative diseases. We previously reported that TREM2 mRNA is highly expresse
Autor:
Jun-ichi Iga, Shunsuke Nakata, Kiyohiro Yamazaki, Yuta Yoshino, Shinichiro Ochi, Shu-ichi Ueno
Publikováno v:
Psychopharmacology. 234:1663-1669
Nitric oxide (NO) is a neurotransmitter that may be related to major depressive disorder (MDD) because the selective neuronal NO synthase (NOS) inhibitor, 7-nitroindazole, induces a dose-dependent antidepressant-like effect. NO modulates major neurot
Autor:
Shu-ichi Ueno, Jun-ichi Iga, Kiyohiro Yamazaki, Taku Yoshida, Yuki Ozaki, Yuta Yoshino, Tomoko Sao, Yu Funahashi, Takaaki Mori
Publikováno v:
Journal of Alzheimer's Disease. 54:1349-1357
Despite the continuing debate about the amyloid hypothesis in Alzheimer's disease (AD), the precise pathogenesis is still unclear. Mixed pathology is common and multiple different protein aggregates are seen in human postmortem brains. Aggregates con
Autor:
Yoko Mori, Shu-ichi Ueno, Shinichiro Ochi, Takaaki Mori, Kiyohiro Yamazaki, Jun-ichi Iga, Yuta Yoshino, Yu Funahashi, Yuki Ozaki
Publikováno v:
Psychiatry research. 278
The gene for dopamine receptor D2 (DRD2) is associated with schizophrenia (SCZ). Epigenetic changes may be related to SCZ pathology. The -141C Ins/Del polymorphism in DRD2 (rs1799732) is functional and associated with SCZ. Fifty SCZ patients and 50 c
Low methylation rates of dopamine receptor D2 gene promoter sites in Japanese schizophrenia subjects
Autor:
Taku Yoshida, Kentaro Kawabe, Yuta Yoshino, Shusuke Numata, Jun-ichi Iga, Tetsuro Ohmori, Yoko Mori, Shunsuke Nakata, Kiyohiro Yamazaki, Shu-ichi Ueno, Takaaki Mori
Publikováno v:
The World Journal of Biological Psychiatry. 17:449-456
According to the dopamine hypothesis, several studies on the gene for the dopamine receptor D2 (DRD2) have been conducted. However, no trait biomarkers on DRD2 are available. We examined whether the methylation rates in the upstream region of DRD2 in
Autor:
Masatoshi Inoshita, Shinji Shimodera, Akira Nishi, Shinya Watanabe, Makoto Kinoshita, Hidehiro Umehara, Tetsuro Ohmori, Jun-ichi Iga, Hirokazu Fujita, Shusuke Numata
Publikováno v:
Human Psychopharmacology: Clinical and Experimental. 31:193-199
The serotonin transporter (5HTT) may be associated with the pathogenesis of major depressive disorder (MDD). The 5HTT-linked polymorphic region (5HTTLPR) genotype may determine how levels of 5HTT mRNA are influenced by promoter methylation. We examin