Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Julia Guetta"'
Publikováno v:
Atherosclerosis. 191:48-53
The haptoglobin genotype has been demonstrated to be an independent risk factor for CVD in multiple epidemiological studies. The primary function of haptoglobin is to mitigate the deleterious effects of extracorpuscular hemoglobin. We sought to deter
Autor:
Shany Blum, Andrew P. Levy, Renliang Zhang, Stanley L. Hazen, Ran Kremer, Rachel Miller-Lotan, Franklin G. Berger, Doron Aronson, Xiaoming Fu, Roy Asaf, Rabea Asleh, Nina S. Levy, Julia Guetta
Publikováno v:
Journal of the American College of Cardiology. 49(1):82-87
Objectives We sought to understand the importance of oxidative stress in explaining why the haptoglobin (Hp) genotype determines myocardial infarction (MI) size in diabetes mellitus (DM). Background Two common alleles (1 and 2) exist at the Hp locus
Autor:
Osher Cohen, Julia Guetta, Ofer Binah, Andrew P. Levy, Mark Shilkrut, Yoram Kanter, Nina S. Levy, Naim Shehadeh, Orit Lache, Stuart Marsh, Rabea Asleh, Ben Enav, Flavio Lejbkowicz
Publikováno v:
Circulation Research. 92:1193-1200
A major function of haptoglobin (Hp) is to bind hemoglobin (Hb) to form a stable Hp-Hb complex and thereby prevent Hb-induced oxidative tissue damage. Clearance of the Hp-Hb complex can be mediated by the monocyte/macrophage scavenger receptor CD163.
Autor:
Valentin Fuster, K. Raman Purushothaman, Julia Guetta, Nina S. Levy, Chingwen Yang, Rachel Miller-Lotan, Andrew P. Levy, Pedro R. Moreno, Joanne E. Levy, Shiri Kalet-Litman, Roy Asaf
Publikováno v:
Arteriosclerosis, thrombosis, and vascular biology. 27(1)
Objective— Intraplaque hemorrhage increases the risk of plaque rupture and thrombosis. The release of hemoglobin (Hb) from extravasated erythrocytes at the site of hemorrhage leads to iron deposition, which may increase oxidation and inflammation i
Publikováno v:
Circulation research. 96(4)
We have recently demonstrated in multiple independent population-based longitudinal and cross sectional analyses that the haptoglobin 2-2 genotype is associated with an increased risk for diabetic cardiovascular disease. The chief function of haptogl