Zobrazeno 1 - 10
of 42
pro vyhledávání: '"Jae J. Song"'
Autor:
Jeong A. Hong, Soo Jin Choi, Zhezhu Han, Geun-Hyeok Oh, Yeonsoo Joo, Hye Jin Choi, Ji Hyun Lee, Jae J. Song, Suwan Ko, Rong Xu
Publikováno v:
Experimental and Molecular Medicine, Vol 51, Iss 10, Pp 1-20 (2019)
Experimental & Molecular Medicine
Experimental & Molecular Medicine
When the adenoviral protein E1B55K binds death domain-associated protein (Daxx), the proteasome-dependent degradation of Daxx is initiated, and adenoviral replication is effectively maintained. Here, we show that the cellular levels of Daxx differ be
Publikováno v:
Apoptosis. 21:351-364
In this study, we demonstrated that survivin downregulation with TRAIL expression greatly enhanced the cytotoxic death of pancreatic cancer cells after gemcitabine treatment. Using real-time RT-PCR, we analyzed five survivin shRNAs to identify the be
Autor:
Won Joo Kim, Jeonghong Shin, Sang Eun Lee, Yeonsoo Joo, Yeon-Soo Kim, Han Sang Kim, Hyongbum Kim, Min Goo Lee, Eun-Ju Choi, Moonkyung Kang, Soonmyung Paik, Jae J. Song, Jae W Choi, Jong In Yook, Minjung Song, Yong Hoon Cha, Jinu Lee, Young Hoon Kim, Eun-Seo Lee
KRAS is the most frequently mutated oncogene in human tumors, and its activating mutations represent important therapeutic targets. The combination of Cas9 and guide RNA from the CRISPR-Cas system recognizes a specific DNA sequence and makes a double
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c231182c63638fe326812b528ec7831a
https://europepmc.org/articles/PMC5848616/
https://europepmc.org/articles/PMC5848616/
Publikováno v:
Cellular Signalling. 25:1288-1300
Curcumin as an anticancer agent was investigated in regards to its ability to regulate the switching of cancer cells from survival to necrotic cell death. At higher concentrations, curcumin induced ROS production leading to JNK and p38 phosphorylatio
Publikováno v:
International Journal of Oncology. 42:1337-1348
To overcome the poor tumor transduction efficiency of adenovirus serotype 5 (Ad5) observed in several types of cancer, the fiber region of Ad5, apart from its tail, was replaced by adenovirus serotype 35 (Ad35). The chimeric Ad5/F35 adenoviral vector
Publikováno v:
Cancer Gene Therapy. 20:82-87
We previously demonstrated that the downregulation of Casitas B-lineage lymphoma (c-Cbl) can sensitize tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis in two different ways. One way is to block the rapid degradation
Autor:
Bo K. Sun, Jae J. Song, Jina Kim, Hyo R. Yoon, Joo Hang Kim, So Y. Kim, Dongxu Kang, Sujin Kang
Publikováno v:
Cellular Signalling. 24:1444-1452
The combination of curcumin and TRAIL and their role in enhancing apoptotic cell death has been reported by many studies. However, the exact molecular mechanism of apoptosis mediated by curcumin and tumor necrosis factor-related apoptosis-inducing li
Autor:
Marco A. Alcala, Yong Tae Kwon, Miroslaw J. Szczepanski, Joo Hang Kim, So Young Kim, Jee Young An, David L. Bartlett, Yong J. Lee, Jae J. Song
Publikováno v:
Cellular Signalling. 22:553-563
We previously reported two modes of development of acquired TRAIL resistance: early phase and late phase [1]. In these studies, we observed that greater Akt activity and the expression of Bcl-xL were related mainly to the late phase of acquired TRAIL
Autor:
Eugene Rha, Moon-Hee Sung, Su Jin Kim, Jae J. Song, Seung-Pyo Hong, Seung-Goo Lee, Su-Lim Choi
Publikováno v:
FEBS Journal. 276:6187-6194
The tyrosine phenol-lyase from Symbiobacterium toebii was engineered to improve both its stability and catalytic activity by the application of random mutagenesis and subsequent reassembly of the acquired mutations. Activity screening of the random l
Autor:
Jae J. Song, Yong J. Lee
Publikováno v:
Cellular Signalling. 20:892-906
Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) has been shown to induce apoptosis through caspase activation in a number of cancer cell lines while displaying minimal or no toxicity on normal cells, suggesting that this protein may h