Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Geethu E. Thomas"'
Autor:
Zachary Blatman, Rose Hurren, Neil MacLean, Ahmed Aman, Taira Kiyota, Kazem Nouri, Rima Al-awar, Moustafa Abohawya, Mehakpreet Saini, Karen Arevalo, Samir H. Barghout, Aaron D. Schimmer, Troy Ketela, Geethu E. Thomas
Publikováno v:
JCI Insight, Vol 6, Iss 5 (2021)
JCI Insight
JCI Insight
TAK-243 is a first-in-class inhibitor of ubiquitin-like modifier activating enzyme 1 that catalyzes ubiquitin activation, the first step in the ubiquitylation cascade. Based on its preclinical efficacy and tolerability, TAK-243 has been advanced to p
Autor:
Geethu E. Thomas, Ayesh K. Seneviratne, Rose Hurren, Neil MacLean, Aaron D. Schimmer, Rashim Pal Singh
Publikováno v:
STAR Protocols
STAR Protocols, Vol 1, Iss 3, Pp 100163-(2020)
STAR Protocols, Vol 1, Iss 3, Pp 100163-(2020)
Summary We describe a method to silence genes in primary acute myeloid leukemia cells by transducing them with shRNA in lentiviral vectors. The transduction of primary non-adherent cells is particularly challenging. The protocol will aid in performin
Autor:
Dilshad H. Khan, Veronique Voisin, Jonathan St-Germain, Andrea Arruda, Geethu E. Thomas, Changjiang Xu, Rose Hurren, Elias Orouji, Mark D. Minden, Boaz Nachmias, Neil MacLean, Brian Raught, Ayesh K. Seneviratne, Gary D. Bader, Xiaoming Wang, Liran I. Shlush, Aaron D. Schimmer, Aaron Botham
Publikováno v:
Blood. 136:22-23
While most patients with acute myeloid leukemia (AML) achieve remission with initial therapy, the majority relapse leading to poor overall survival. Relapse is frequently driven by a rare subset of leukemic stem cells (LSC). Understanding biological
Autor:
Neil MacLean, Elias Orouji, Kerstin B. Kaufmann, Rose Hurren, Mark D. Minden, Aaron Botham, Veronique Voisin, Grace Egan, Geethu E. Thomas, Boaz Nachmias, Rashim Pal Singh, John E. Dick, Marcela Gronda, Jordan Chin, Dilshad H. Khan, Gary D. Bader, Laura Gracia Prat, Aaron D. Schimmer, Andrea Arruda, Xiaoming Wang
Publikováno v:
Cancer Research. 81:3099-3099
Mitochondrial metabolites affect epigenetic marks, but it is largely unknown whether mitochondrial metabolic enzymes can directly localize to the nucleus to regulate stem cell function in AML. Here, we discovered that the mitochondrial enzyme, Hexoki
Abstract 3098: Leukemia stem cells demonstrate enhanced DNA damage repair and chemoresistance in AML
Autor:
Neil MacLean, Parasvi S. Patel, Razq Hakem, Grace Egan, Aaron D. Schimmer, Rose Hurren, Veronique Voisin, Geethu E. Thomas
Publikováno v:
Cancer Research. 81:3098-3098
Leukemia stem cells demonstrate enhanced DNA damage repair and chemoresistance in AML Relapse of acute myeloid leukemia (AML) is common and the main cause of mortality in this disease. Leukemia stem cells (LSCs) contribute to relapse however the mech
Autor:
Mathieu Lupien, Yulia Jitkova, Michael Mullokandov, Helen Loo Yau, Rima Al-awar, James R. Hawley, Rose Hurren, Troy Ketela, S. Kim, Veronique Voisin, Neil MacLean, Daniel D. De Carvalho, Mark D. Minden, Geethu E. Thomas, Val A. Fajardo, Ahmed Aman, Zhenyue Hao, Zaza Khuchua, G. Wei Xu, Gary D. Bader, Richard P. Bazinet, Juan J. Aristizabal Henao, Mingjing Xu, Paul J. LeBlanc, Ayesh K. Seneviratne, Steven M. Claypool, Steven M. Chan, Xiaoming Wang, Atan Gross, Aaron D. Schimmer, Ken D. Stark, David Sharon, Raphaël Chouinard-Watkins, Danny V. Jeyaraju, Caitlin Schafer, Marcela Gronda
Summary Tafazzin (TAZ) is a mitochondrial transacylase that remodels the mitochondrial cardiolipin into its mature form. Through a CRISPR screen, we identified TAZ as necessary for the growth and viability of acute myeloid leukemia (AML) cells. Genet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43b74e60e809d7c98db8697836fef410
https://europepmc.org/articles/PMC7137093/
https://europepmc.org/articles/PMC7137093/
Autor:
Rose Hurren, Razq Hakem, Parasvi S. Patel, Neil MacLean, Grace Egan, Aaron D. Schimmer, Geethu E. Thomas
Publikováno v:
Blood. 136:2-2
While most patients with AML achieve remission with standard induction chemotherapy, the majority ultimately relapse. Relapsed AML is due, at least in part, to the persistence of chemoresistant leukemia stem cells (LSCs). The mechanisms of chemoresis
Autor:
Mark D. Minden, Neil MacLean, Steven M. Chan, Sanduni Liyanagae, Sara Mirali, Changjiang Xu, James R. Hawley, Samir H. Barghout, Rashim Pal Singh, Elias Orouji, Aaron D. Schimmer, Xiaoming Wang, Gary D. Bader, Marcela Gronda, Dilshad H. Khan, Joelle Soriano, Mathieu Lupien, Veronique Voisin, Yulia Jitkova, Danny V. Jeyaraju, Geethu E. Thomas, David Sharon, Adina Borenstein, Rose Hurren, Ayesh K. Seneviratene, Andrea Arruda
Publikováno v:
Cell Stem Cell. 26:926-937.e10
Leukemic stem cells (LSCs) rely on oxidative metabolism and are differentially sensitive to targeting mitochondrial pathways, which spares normal hematopoietic cells. A subset of mitochondrial proteins is folded in the intermembrane space via the mit
Autor:
Zachary Blatman, Rose Hurren, Aaron D. Schimmer, Geethu E. Thomas, Samir H. Barghout, Neil MacLean, G. Wei Xu
Publikováno v:
Blood. 132:1350-1350
UBA1 is the major ubiquitin-activating enzyme that initiates the ubiquitylation cascade whereby proteins are tagged with mono- or polyubiquitin to mark them for proteasomal degradation or modify their functions. Despite having equal levels of UBA1 pr