Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Gautam Sikka"'
Autor:
Vanessa C. Pau, Gautam Sikka, Benjamin D. Levine, Jochen Steppan, Lakshmi Santhanam, Dan E. Berkowitz, Young Jun Oh, Daniel Nyhan, Valeriani R. Bead
Publikováno v:
Amino Acids. 49:695-704
Aging is associated with increased cardiomyocyte loss, left-ventricular hypertrophy, and the accumulation of extracellular matrix, which results in declining cardiac function. The role of the matrix crosslinking enzyme, tissue transglutaminase (TG2),
Autor:
Gautam Sikka, Deepesh Pandey, Lewis H. Romer, Sungwoo Ryoo, Yehudit Bergman, Dan E. Berkowitz, Jae Hyung Kim
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 34:1556-1566
Objective— Arginase 2 (Arg2) is a critical target in atherosclerosis because it controls endothelial nitric oxide, proliferation, fibrosis, and inflammation. Regulators of Arg2 transcription in the endothelium have not been characterized. The goal
Autor:
Gautam Sikka, Sineád M. Nyhan, Artin A. Shoukas, Ayushi Ahuja, Anthony R. White, Jorge A. Uribe, Jochen Steppan, Dan E. Berkowitz
Publikováno v:
Anesthesia & Analgesia. 115:1290-1295
BACKGROUND Vasopressin is frequently used to treat catecholamine-resistant vasodilatory shock. It enhances the vasoconstrictor effects of catecholamines at concentrations of vasopressin that have none or only minimal intrinsic pressor effects. Howeve
Autor:
Alexey M. Belkin, Eric C. Tuday, Daniel Nyhan, Jae Hyung Kim, Anne M. Macgregor, David Yin, Jessilyn Dunn, Young Jun Oh, Sarah R. Gutbrod, Nicholas A. Flavahan, Marc K. Halushka, Alanah Webb, Lakshmi Santhanam, Artin A. Shoukas, Gautam Sikka, Dan E. Berkowitz, Phillip Dowzicky, Maggie Kuo
Publikováno v:
Circulation Research. 107:117-125
Rationale : Although an age-related decrease in NO bioavailability contributes to vascular stiffness, the underlying molecular mechanisms remain incompletely understood. We hypothesize that NO constrains the activity of the matrix crosslinking enzyme
Autor:
Sadia K. Gazi, Sylvain Doré, Abdullah Shafique Ahmad, Joseph T. Coyle, Jeffrey T. Ehmsen, Emil Zeynalov, Solomon H. Snyder, Gautam Sikka, Asif K. Mustafa, Roxanne K. Barrow
Publikováno v:
The Journal of Neuroscience. 30:1413-1416
d-Serine, formed froml-serine by serine racemase (SR), is a physiologic coagonist at NMDA receptors. Using mice with targeted deletion of SR, we demonstrate a role ford-serine in NMDA receptor-mediated neurotoxicity and stroke. Brain cultures of SR-d
Autor:
Kevin G. Soucy, Gautam Sikka, Hunter C. Champion, Gaurav Gupta, Artin A. Shoukas, Dan E. Berkowitz, David W. Christianson, Hyun Kyo Lim, Nicholas J. Alp, Sungwoo Ryoo, David Huso, Eric C. Tuday, Gary Gerstenblith, Alexandre M. Benjo, Lakshmi Santhanam, Daniel Nyhan, Andre Camara, Jayson S. Sohi, Monica Ilies, Hyun Kyung Lim, Ezra Baraban
Publikováno v:
Circulation Research. 102:923-932
Oxidized low-density lipoproteins increase arginase activity and reciprocally decrease endothelial NO in human aortic endothelial cells. Here, we demonstrate that vascular endothelial arginase activity is increased in atherogenic-prone apolipoprotein
Publikováno v:
Chest. 150:439A
Autor:
Janna V Serbo, Deepesh Pandey, Dan E. Berkowitz, Maggie Kuo, Anil K. Bhunia, Fumin Chang, Yehudis Bergman, Gautam Sikka, Lew Romer
Publikováno v:
Nitric Oxide. 42:101-102
Publikováno v:
Circulation Research. 110
We first acknowledge the profound contribution that Edwards, Feletou, and Weston have made over many years to our understanding of the role of endothelial-derived hyperpolarizing factors in the regulation of vascular function in health and disease. I
Autor:
Daniel Nyhan, Sophia Ottleben, Jochen Steppan, Jonathan Sevilla, Viachaslau Barodka, Shayer Chowdhury, Lakshmi Santhanam, Gautam Sikka, Sarah Campbell, Desmond McNelis, Dan E. Berkowitz
Publikováno v:
Nitric Oxide. 27:S41
Hypertension (HTN) increases the risk for cardiac disease and stroke. Endogenous hydrogen sulfide (H 2 S), which plays a prominent role in a multitude of pathologies like inflammation/sepsis, hypertension, peripheral and cerebro-vascular, and coronar