Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Erdem Goker"'
Autor:
Joseph R. Bertino, Madhu Mazumdar, Tanya M. Trippett, Richard Gorlick, Erdem Goker, Wayne F. Flintoff, Peter G. Steinherz, Yaroslav Elisseyeff
Publikováno v:
Blood. 89:1013-1018
Methotrexate (MTX) transport was examined in 27 patients with untreated acute lymphocytic leukemia (ALL) and 31 patients with relapsed ALL using a previously described fluorescent MTX analog (PT430) displacement assay (Blood 80:1158, 1992). Only 13%
Publikováno v:
Scopus-Elsevier
The mechanisms of intrinsic and acquired resistance to methotrexate (MTX) in human tumors are reviewed herein. In blasts from patients with acute lymphocytic leukemia, resistance mechanisms found are decreased uptake and increased dihydrofolate reduc
Autor:
Erdem Goker, Madhu Mazumdar, Peter G. Steinherz, Barbara Schnieders, Tanya M. Trippett, Ellin Berman, A Kheradpour, Mark Waltham, Cuiwen Tan, Y Elisseyeff
Publikováno v:
Blood. 86(2)
Although dihydrofolate reductase (DHFR) gene amplification is a common mechanism of resistance to methotrexate (MTX) in tumor cell lines, with the exception of a few case reports, the incidence of this phenomenon as a mechanism of MTX resistance in t
Autor:
M. Volkenandt, HJ Lenz, K. Danenberg, T. Horikosh, R. Wienecke, J. Buer, Joseph R. Bertino, Peter V. Danenberg, Olaf M. Koch, Debabrata Banerjee, Erdem Goker
Publikováno v:
Haematology and Blood Transfusion / Hämatologie und Bluttransfusion ISBN: 9783642783524
The detection of a monoclonal lymphoid population in a clinical specimen is highly suggestive for a neoplastic lymphoproliferative disease. There are only few disorders where mono- or oligoclonality is of benign origin and is not associated with mali
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::12a896631834eacb2efc27f82bcd68c3
https://doi.org/10.1007/978-3-642-78350-0_8
https://doi.org/10.1007/978-3-642-78350-0_8
Autor:
Barbara Schnieders, Jianguo Fan, Debabrata Banerjee, Emine A. Ercikan-Abali, Wei Wei Li, Erdem Goker, Richard Gorlick, Mark Waltham, Daniel Hochhauser, Joseph R. Bertino
Publikováno v:
Scopus-Elsevier
Methotrexate (MTX) is a clinically important antifolate that has been used in combination with other chemotherapeutic agents in the treatment of malignancies including acute lymphocytic leukemia, osteosarcoma, carcinomas of the breast, head and neck,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49b388912fe65494376fce5c085a0be7
http://www.scopus.com/inward/record.url?eid=2-s2.0-0029433839&partnerID=MN8TOARS
http://www.scopus.com/inward/record.url?eid=2-s2.0-0029433839&partnerID=MN8TOARS