Zobrazeno 1 - 10
of 65
pro vyhledávání: '"Deok-Ho Kim"'
Autor:
Abigail Nagle, Kelly R. Stevens, Deok Ho Kim, Peter Kim, Nickolas Chu, Cole A. DeForest, Darrian Bugg, Ross C. Bretherton, Jagadambika J. Gunaje, Jennifer Davis, Emily Olszewski, Austin E Schumacher
Publikováno v:
Circ Res
Rationale: Myocardial infarction causes spatial variation in collagen organization and phenotypic diversity in fibroblasts, which regulate the heart’s ECM (extracellular matrix). The relationship between collagen structure and fibroblast phenotype
Publikováno v:
Trends Biotechnol
Tissues- and organs-on-chips are microphysiological systems (MPSs) that model the architectural and functional complexity of human tissues and organs that is lacking in conventional cell monolayer cultures. While substantial progress has been made in
Autor:
Jonathan H. Tsui, Patrick T. Smith, Deok Ho Kim, Benjaporn Narupai, S. Cem Millik, Ryan T. Shafranek, Alshakim Nelson
Publikováno v:
Biomacromolecules. 21:484-492
Bio-sourced and biodegradable polymers for additive manufacturing could enable the rapid fabrication of parts for a broad spectrum of applications ranging from healthcare to aerospace. However, a limited number of these materials are suitable for vat
Autor:
Shiri Levy, Yuliang Wang, Andrea Leonard, Hannele Ruohola-Baker, Elisa C. Clark, Tuula Manninen, Kevin M. Beussman, Jason W. Miklas, Deok Ho Kim, Oliver Fiehn, Nathan J. Sniadecki, Charles E. Murry, Daniel Raftery, Anup Madan, Xiulan Yang, Jesse Macadangdang, Alec S.T. Smith, Damien Detraux, Anu Suomalainen, Megan R. Showalter, Peter Hofsteen
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-21 (2019)
Nature Communications
Nature Communications, vol 10, iss 1
Nature communications, vol 10, iss 1
Nature Communications
Nature Communications, vol 10, iss 1
Nature communications, vol 10, iss 1
Mitochondrial trifunctional protein deficiency, due to mutations in hydratase subunit A (HADHA), results in sudden infant death syndrome with no cure. To reveal the disease etiology, we generated stem cell-derived cardiomyocytes from HADHA-deficient
Autor:
Alec S. T. Smith, Changho Chun, Jennifer Hesson, Julie Mathieu, Paul N. Valdmanis, David L. Mack, Byung-Ok Choi, Deok-Ho Kim, Mark Bothwell
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Frontiers in Cell and Developmental Biology
Frontiers in Cell and Developmental Biology
Gene editing technologies hold great potential to enhance our ability to model inheritable neurodegenerative diseases. Specifically, engineering multiple amyotrophic lateral sclerosis (ALS) mutations into isogenic cell populations facilitates determi
Autor:
Deok Ho Kim, Mariana X. Byndloss, Seungmi Ryu, Woongjae Yoo, Zieba Jk, Nicolas G. Shealy, Calcutt Mw, Nora J. Foegeding, Catherine D. Shelton, Teresa P. Torres, J. H. Kim
SUMMARYThe gut microbiota benefits the host by limiting enteric pathogen expansion (colonization resistance) partially via the production of inhibitory metabolites. Propionate, a short-chain fatty acid produced by microbiota members, is proposed to m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b067b9b9ba7791a249ec146943d0fbde
https://doi.org/10.1101/2021.05.25.445690
https://doi.org/10.1101/2021.05.25.445690
Autor:
H.-J. Sung, Tae Min Kim, I. Yong, R. D. Delos Reyes, Jayoung Ku, Moonyoung Kang, S. Cho, Je-Yoel Cho, Dongryung Lee, Pavel Sinitcyn, Yoosik Kim, Mark Borris D. Aldonza, Pilnam Kim, Han Suk Ryu, Yongsuk Ku, Ryeongeun Cho, J. Cha, Deok Ho Kim, GwangSik Park, Sun-Whe Kim
Cancer secretome is a reservoir for aberrant glycosylation. How therapies alter this post-translational cancer hallmark and the consequences thereof remain elusive. Here we show that an elevated secretome fucosylation is a pan-cancer signature of bot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a581607b2c2ee5c66c753858ad3b1b82
https://doi.org/10.1101/2021.04.21.440719
https://doi.org/10.1101/2021.04.21.440719
Autor:
Kevin M. Beussman, Charles E. Murry, Deok Ho Kim, Andrea Leonard, Hung Fat Tse, Jay Shendure, Alec S.T. Smith, William Stafford Noble, Nathan J. Sniadecki, Lil Pabon, Paul A. Fields, Alessandro Bertero
Publikováno v:
The Journal of Cell Biology
Mozzetta and Tedesco preview work from the Murry laboratory yielding insight into cardiac laminopathy pathogenesis mechanisms by analyzing chromatin compartment dynamics in a haploinsufficient model of the disease.
Lamins A and C are intermediat
Lamins A and C are intermediat
Autor:
Corrado Poggesi, Chiara Tesi, Alice Ward Racca, Michael R. Hoopmann, Cecilia Ferrantini, J. Manuel Pioner, Lil Pabon, Jordan M. Klaiman, Veronica Muskheli, Michael Regnier, Xuan Guan, Martin K. Childers, Deok Ho Kim, David L. Mack, Charles E. Murry, Robert L. Moritz, Jesse Macadangdang
Publikováno v:
Cardiovasc Res
Aims Heart failure invariably affects patients with various forms of muscular dystrophy (MD), but the onset and molecular sequelae of altered structure and function resulting from full-length dystrophin (Dp427) deficiency in MD heart tissue are poorl
Autor:
Hans Reinecke, Deok Ho Kim, Lil Pabon, Joy Xu, Kai Chun Yang, Akiko Futakuchi-Tsuchida, Michael Regnier, Maria V. Razumova, Peter Hofsteen, Charles E. Murry, J. Carter Ralphe, Cody Schopf, Alex Jiao, Astrid Breitbart, Robert J. Boucek, Willem J. de Lange
Publikováno v:
JACC: Basic to Translational Science
JACC: Basic to Translational Science, Vol 3, Iss 6, Pp 728-740 (2018)
JACC: Basic to Translational Science, Vol 3, Iss 6, Pp 728-740 (2018)
Visual Abstract
Highlights • Many cardiomyopathy families have genetic variants whose significance is unknown. We studied a novel (E848G) mutation in MYH7, a sarcomeric protein. • Patient-specific induced pluripotent stem cell–derived card
Highlights • Many cardiomyopathy families have genetic variants whose significance is unknown. We studied a novel (E848G) mutation in MYH7, a sarcomeric protein. • Patient-specific induced pluripotent stem cell–derived card