Zobrazeno 1 - 10
of 165
pro vyhledávání: '"Dean W. Felsher"'
Autor:
Renumathy Dhanasekaran, Nishita Kothary, Maya Krishnan, Jun Yin, Sharon J. Pitteri, Vinodhini Arjunan, Dean W. Felsher, Jangho Park, Anand Rajan Kd, Mindie H. Nguyen, Abel Bermudez, Nam S. Hoang, Fernando Jose Garcia Marques, Olivia A. Girvan
Publikováno v:
Hepatology
BACKGROUND AND AIMS Vascular invasion (VI) is a critical risk factor for HCC recurrence and poor survival. The molecular drivers of vascular invasion in HCC are open for investigation. Deciphering the molecular landscape of invasive HCC will help ide
Publikováno v:
Cancer Res
Myc and Ras are two of the most commonly activated oncogenes in tumorigenesis. Together and independently they regulate many cancer hallmarks including proliferation, apoptosis, and self-renewal. Recently, they were shown to cooperate to regulate hos
Autor:
Stacey J. Adam, Renumathy Dhanasekaran, David I. Bellovin, Vinodhini Arjunan, Alekesey Yevtodiyenko, Jangho Park, Dean W. Felsher, Julia Arzeno, Anand Rajan Kd, Meital Gabay, Hanan Fernando, Sergei Gryanzov
Publikováno v:
Molecular Therapy. Nucleic Acids
Molecular Therapy: Nucleic Acids, Vol 21, Iss, Pp 850-859 (2020)
Molecular Therapy: Nucleic Acids, Vol 21, Iss, Pp 850-859 (2020)
The MYC oncogene is dysregulated in most human cancers and hence is an attractive target for cancer therapy. We and others have shown experimentally in conditional transgenic mouse models that suppression of the MYC oncogene is sufficient to induce r
Autor:
Steve Carbajal, Okkyung Rho, John DiGiovanni, Phuoc T. Tran, Dean W. Felsher, Nicholas Blazanin, Fernando Eguiarte-Solomon
Publikováno v:
Molecular carcinogenesisREFERENCES. 60(5)
The transcription factor Twist1 has been reported to be essential for the formation and invasiveness of chemically induced tumors in mouse skin. However, the impact of keratinocyte-specific Twist1 deletion on skin carcinogenesis caused by UVB radiati
Publikováno v:
The Myc Gene ISBN: 9781071614754
The tetracycline regulatory system provides a tractable strategy to interrogate the role of oncogenes in the initiation, maintenance, and regression of tumors through both spatial and temporal control of expression. This approach has several potentia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::334b747ae37603d80bb7ea704155f1c6
https://doi.org/10.1007/978-1-0716-1476-1_16
https://doi.org/10.1007/978-1-0716-1476-1_16
Autor:
Daniel F. Liefwalker, Holden T. Maecker, Renumathy Dhanasekaran, Wadie D. M. Fernandez, Dean W. Felsher, Srividya Swaminathan, Line Dam Heftdal, Crista Horton, Anja Deutzmann, Mariola Liebersbach, Aida S. Hansen, Adriane Mosley
Publikováno v:
Nature Communications
Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
The MYC oncogene drives T- and B- lymphoid malignancies, including Burkitt’s lymphoma (BL) and Acute Lymphoblastic Leukemia (ALL). Here, we demonstrate a systemic reduction in natural killer (NK) cell numbers in SRα-tTA/Tet-O-MYCON mice bearing MY
Autor:
Jangho Park, Mustafa A. Barbhuiya, Nia Adeniji, Maya Krishnan, Sibu P. Kuruvilla, Ian Lai, Anand Rajan Kd, Meital Gabay, David I. Bellovin, Theodore Hu, Virginie Baylot, Renumathy Dhanasekaran, Ling Tong, Phuoc T. Tran, Minsoon Kim, Kasthuri Kannan, Andrew J. Gentles, Dean W. Felsher
Publikováno v:
eLife, Vol 9 (2020)
eLife
eLife
Metastasis is a major cause of cancer mortality. We generated an autochthonous transgenic mouse model whereby conditional expression of MYC and Twist1 enables hepatocellular carcinoma (HCC) to metastasize in >90% of mice. MYC and Twist1 cooperate and
Publikováno v:
Scientific Reports
Scientific Reports, Vol 9, Iss 1, Pp 1-9 (2019)
Scientific Reports, Vol 9, Iss 1, Pp 1-9 (2019)
Accurate assessment of changes in cellular differentiation status in response to drug treatments or genetic perturbations is crucial for understanding tumorigenesis and developing novel therapeutics for human cancer. We have developed a novel computa
Autor:
Beatrice Dankworth, Ming Jiang, Michael Howell, Dean W. Felsher, Arvin M. Gouw, Becky Saunders, Barrie Peck, Julian Downward, Mathias T. Rosenfeldt, Werner Schmitz, Heike Miess, Almut Schulze
Publikováno v:
Oncogene. 37:5435-5450
Metabolic reprogramming is a prominent feature of clear cell renal cell carcinoma (ccRCC). Here we investigated metabolic dependencies in a panel of ccRCC cell lines using nutrient depletion, functional RNAi screening and inhibitor treatment. We foun
Autor:
Candace J. Poole, Honglin Li, Atul Lodh, Wenli Zheng, Aleksey Yevtodiyenko, Daniel F. Liefwalker, Jan van Riggelen, Dean W. Felsher
Publikováno v:
Oncotarget
// Candace J. Poole 1, * , Wenli Zheng 1, * , Atul Lodh 1 , Aleksey Yevtodiyenko 2 , Daniel Liefwalker 2 , Honglin Li 1 , Dean W. Felsher 2 and Jan van Riggelen 1 1 Augusta University, Department of Biochemistry and Molecular Biology, Augusta, GA 309