Zobrazeno 1 - 10
of 49
pro vyhledávání: '"Dawang Zhou"'
Autor:
Qiao Wu, Bo Zhou, Hang-zi Chen, Dawang Zhou, Wei-jia Wang, Kang Cheng, Fu-nan Li, Ru-yue Sun, Yuan-li Ai, Fan-jian Liu, Zhi-hong Jiang, Jia-yuan Zhang, Bao-rui Wang
Publikováno v:
Cell Research
Pyroptosis is a form of regulated cell death mediated by gasdermin family members, among which the function of GSDMC has not been clearly described. Herein, we demonstrate that the metabolite α-ketoglutarate (α-KG) induces pyroptosis through caspas
Autor:
Dawang Zhou, Shihao Zhang
Publikováno v:
Current Opinion in Cell Biology. 61:64-71
Liver cancer, hepatocellular carcinoma (HCC) in particular, is one of the deadliest cancers worldwide. Although the etiologies for liver oncogenesis are relatively well defined, the exact mechanisms leading to cancer development remain elusive. The H
Autor:
Jinjia Zhang, Yiran Shi, Jing Geng, Weihong Yuan, Ping Wang, Hao Zhao, Dawang Zhou, Bingying Yang, Xianming Deng, Funiu Qin, Lixin Hong, Yujie Sun, Junhong Li, Lanfen Chen, Congying Wu, Changchuan Xie
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Nature Communications
Nature Communications
TLR4 signaling plays key roles in the innate immune response to microbial infection. Innate immune cells encounter different mechanical cues in both health and disease to adapt their behaviors. However, the impact of mechanical sensing signals on TLR
Publikováno v:
Ann Transl Med
Background The expression profile of lncRNAs in coronary artery disease (CAD) patients has not yet been fully explored. Therefore, the current study aimed to investigate lncRNA-based prognostic biomarkers for CAD. Methods The expression profiles of l
Autor:
Fei Chen, Dawang Zhou, Jiancheng Ding, Wen Liu, Aicun Li, Lei Zhang, Han You, Zhe Meng, Zhicheng Gong, Ronggui Hu, Yuanpei Li, Jialiang Huang, Qing Li, Jing Ye
Publikováno v:
Advanced Science
Advanced Science, Vol 8, Iss 15, Pp n/a-n/a (2021)
Advanced Science, Vol 8, Iss 15, Pp n/a-n/a (2021)
Genomic amplification of OTUD7B is frequently found across human cancers. But its role in tumorigenesis is poorly understood. Lysine‐specific demethylase 1 (LSD1) is known to execute epigenetic regulation by forming corepressor complex with CoREST/
Autor:
Jing Wang, Qiyao Chai, Yanzhao Zhong, Lingqiang Zhang, Yong Zhang, Wenzhu Dong, Cui Hua Liu, George F. Gao, Pupu Ge, Yu Pang, Dawang Zhou, Wei Li, Xudong Wang, Bingxi Li, Zhe Lu, Lihua Qiang
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-17 (2019)
Nature Communications
Nature Communications
Ubiquitin-mediated xenophagy, a type of selective autophagy, plays crucial roles in host defense against intracellular pathogens including Mycobacterium tuberculosis (Mtb). However, the exact mechanism by which host ubiquitin targets invaded microbes
Autor:
Kang Cheng, Dawang Zhou, Yuan-li Ai, Hang-zi Chen, Ru-yue Sun, Jiahuai Han, Jia-yuan Zhang, Bo Zhou, Xian-shuo Liu, Qiao Wu
Publikováno v:
Cell Research
Iron has been shown to trigger oxidative stress by elevating reactive oxygen species (ROS) and to participate in different modes of cell death, such as ferroptosis, apoptosis and necroptosis. However, whether iron-elevated ROS is also linked to pyrop
Autor:
Hui Shao, Cheng Nian, Dawang Zhou, Jing Geng, Jin Ding, Yuxi Li, Xianming Deng, Weiji Zhang, Hao Zhao, Shuhai Lin, Chen Xiao, Lihong Chen, Qian Zhao, Randy L. Johnson, Shihao Zhang, Qingxu Liu, Xiaolong Liu, Dongxue Su, Lixin Hong, Qinghua Chen, Junhong Li, Qiao Wu, Lanfen Chen, Jiaxin Li, Rongqin Ke
Publikováno v:
Cell. 184(22)
Glucose consumption is generally increased in tumor cells to support tumor growth. Interestingly, we report that glycogen accumulation is a key initiating oncogenic event during liver malignant transformation. We found that glucose-6-phosphatase (G6P
Autor:
Dawang Zhou, Xiaolin Xiong, Hao Zhao, Jiaqi Peng, Xiufeng Sun, Xun Li, Shujuan Yu, Jiahui Gao, Ping Wang, Jiahuai Han, Linrong Lu, Randy L. Johnson, Lanfen Chen, Yiran Shi, Nengming Xiao, Changchuan Xie, Jing Geng, Lixin Hong
Publikováno v:
Nature Immunology. 18:800-812
An imbalance in the lineages of immunosuppressive regulatory T cells (Treg cells) and the inflammatory TH17 subset of helper T cells leads to the development of autoimmune and/or inflammatory disease. Here we found that TAZ, a coactivator of TEAD tra
Autor:
Pei-pei Hou, Sheng-fu Wu, Dawang Zhou, Wenxiu Zhao, Jianming Liu, Qiao Wu, Hang-zi Chen, Xiaomin Wang, Li-juan Luo, Lu-ming Yao, Qinghua Chen, Xue-li Bian, Zhi-yuan Zhang, Jia-xin Zhou, Qi-tao Chen
Publikováno v:
Molecular cell. 78(6)
Tumor-derived extracellular vesicles are important mediators of cell-to-cell communication during tumorigenesis. Here, we demonstrated that hepatocellular carcinoma (HCC)-derived ectosomes remodel the tumor microenvironment to facilitate HCC progress