Zobrazeno 1 - 10
of 20
pro vyhledávání: '"David G. Hoel"'
Publikováno v:
International Journal of Radiation Biology
Purpose: This review evaluates the role of dose rate on cell and molecular responses. It focuses on the influence of dose rate on key events in critical pathways in the development of cancer. This approach is similar to that used by the U.S. EPA and
Autor:
Lawrence C. Mohr, Apryl Bronley-DeLancey, David J. Jollow, David G. Hoel, JoEllyn M McMillan, David C. McMillan
Publikováno v:
Environmental Health Perspectives
BACKGROUND: Trichloroethylene (TCE) is a suspected human carcinogen and a common groundwater contaminant. Chloral hydrate (CH) is the major metabolite of TCE formed in the liver by cytochrome P450 2E1. CH is metabolized to the hepatocarcinogen trichl
Publikováno v:
Urology. 66:587-592
Objectives To analyze the differences in the plasma levels of insulin-like growth factor-I (IGF-I), IGF-binding protein-3 (IGFBP-3), and their ratio between black and white men while controlling for factors that could confound the relationship betwee
Autor:
Tomas Radivoyevitch, David G. Hoel
Publikováno v:
Mathematical Biosciences. 162:85-101
Formation of the BCR–ABL chromosomal translocation t (9;22)( q 34; q 11) is essential to the genesis of chronic myeloid leukemia (CML). An interest in the dose-response of radiation induced CML therefore leads naturally to an interest in the dose-r
Publikováno v:
Mathematical Biosciences. 149:107-136
When ionizing radiation strikes a cell it induces DNA double strand breaks (DSBs). Subsequently, some of the DSBs misrejoin and thus cause alterations in the size distribution of the DNA fragments. We derive a system of non-linear integro-differentia
Autor:
David G. Hoel, Christopher J. Portier
Publikováno v:
Environmental Health Perspectives
Carcinogenesis data for 315 chemicals were obtained from the National Cancer Institute-National Toxicology Program (NCI-NTP) bioassay programs and were analyzed to examine the shape of carcinogenesis dose-response curves. Tumor site data were more of
Publikováno v:
Risk Analysis. 12:115-121
The use of average qualitative concordance between two bioassay endpoints is considered, with emphasis directed at agreement between rats and mice from results of long-term carcinogenicity studies. It is noted that concordance varies as a function of
Publikováno v:
Public health nutrition. 10(1)
ObjectiveHigher levels of insulin-like growth factor-I (IGF-I) and lower levels of IGF binding protein-3 (IGFBP-3) have been associated with an increased risk of prostate cancer. Nutrition is known to partially regulate IGF levels and it is possible
Autor:
Tomas Radivoyevitch, David G. Hoel
Publikováno v:
Radiation and environmental biophysics. 39(3)
Radiation cancer risks are typically deter- mined by the use of simple statistical descriptions of epidemiological data. It is important in risk assessment in general, however, to attempt to incorporate as much biological information into the risk mo
Autor:
Frederick J. de Serres, David G. Hoel
Publikováno v:
Mutation Research/Environmental Mutagenesis and Related Subjects. 253:1-3