Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Christoph Klenk"'
Autor:
Christoph Klenk, Maria Scrivens, Anina Niederer, Shuying Shi, Loretta Mueller, Elaine Gersz, Maurice Zauderer, Ernest S. Smith, Ralf Strohner, Andreas Plückthun
Directed evolution in bacterial or yeast display systems has been successfully used to improve stability and expression of G protein-coupled receptors for structural and biophysical studies. Yet, several receptors cannot be tackled in microbial syste
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2453d77035b033dc3434d9e096e17f47
https://www.zora.uzh.ch/id/eprint/233902/
https://www.zora.uzh.ch/id/eprint/233902/
Publikováno v:
Molecules
Molecules, Vol 26, Iss 1465, p 1465 (2021)
Molecules, Vol 26, Iss 1465, p 1465 (2021)
Membrane proteins such as G protein-coupled receptors (GPCRs) exert fundamental biological functions and are involved in a multitude of physiological responses, making these receptors ideal drug targets. Drug discovery programs targeting GPCRs have b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::150d7a9da23de08d1c5007ceb076b0e6
https://doi.org/10.5167/uzh-210190
https://doi.org/10.5167/uzh-210190
Autor:
Peer R. E. Mittl, Philipp Heine, S.A. Eberle, Santiago Vacca, Lisa Merklinger, Lena Morstein, Pascal Egloff, Mattia Deluigi, Patrick Ernst, Alexander Klipp, Andreas Plückthun, Theodore M. Kamenecka, Yuanjun He, Christoph Klenk, Annemarie Honegger
Publikováno v:
Science Advances
Crystal structures of NTSR1 bound to agonists, inverse agonists, and in the apo state enabled by a novel fusion to DARPin D12.
Neurotensin receptor 1 (NTSR1) and related G protein–coupled receptors of the ghrelin family are clinically unexploi
Neurotensin receptor 1 (NTSR1) and related G protein–coupled receptors of the ghrelin family are clinically unexploi
Autor:
James Yu, Franz Hagn, Mahmoud L. Nasr, Alan Brown, Lisa Merklinger, Zhen-Yu Sun, Lena Morstein, Zi-Fu Wang, Gerhard Wagner, Hao Wu, Miao Gui, Christoph Klenk, Christoph Gorgulla, Andreas Plückthun, Meng Zhang
Publikováno v:
Nat. Struct. Mol. Biol. 28, 258-267 (2021)
Nat Struct Mol Biol
Nat Struct Mol Biol
G protein coupled receptors (GPCRs) are the largest superfamily of transmembrane proteins and the targets of over 30% of currently marketed pharmaceuticals1,2. Although several structures have been solved for GPCR-G protein complexes3–17, structura
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87e3dfa305bbce4d577593bb87aacee0
https://doi.org/10.21203/rs.3.rs-57572/v1
https://doi.org/10.21203/rs.3.rs-57572/v1
The parathyroid hormone 1 receptor (PTH1R) is a major regulator of mineral ion homeostasis and bone metabolism and is thus considered an attractive drug target for the treatment of disorders in calcium metabolism and bone-related diseases such as ost
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f8e36bbdc07cc8bc225e5b6dd476ed0
https://doi.org/10.5167/uzh-181173
https://doi.org/10.5167/uzh-181173
Autor:
Prakash Rucktooa, Janosch Ehrenmann, Jendrik Schöppe, Marco Schütz, Christoph Klenk, Andrew S. Doré, Andreas Plückthun
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
Nature Communications
Nature Communications
Neurokinins (or tachykinins) are peptides that modulate a wide variety of human physiology through the neurokinin G protein-coupled receptor family, implicated in a diverse array of pathological processes. Here we report high-resolution crystal struc
Autor:
Pascal Egloff, Christoph Klenk, Lutz Kummer, Jendrik Schöppe, Andreas Plückthun, Erik Sedlák, Matthias Hillenbrand, Janosch Ehrenmann, Gabriela Nagy-Davidescu, Marco Schütz
Publikováno v:
Scientific Reports
Despite recent successes, many G protein-coupled receptors (GPCRs) remained refractory to detailed molecular studies due to insufficient production yields, even in the most sophisticated eukaryotic expression systems. Here we introduce a robust metho
Publikováno v:
Scientific Reports
Structural and biophysical studies as well as drug screening approaches on G protein-coupled receptors (GPCRs) have been largely hampered by the poor biophysical properties and low expression yields of this largest class of integral membrane proteins
Publikováno v:
Molecular Pharmacology
The parathyroid hormone receptor (PTHR) is a class B G protein-coupled receptor (GPCR) that mediates the endocrine and paracrine effects of parathyroid hormone and related peptides through the activation of phospholipase C beta-, adenylyl cyclase-, m
Autor:
Alexander Batyuk, Renato Zenobi, Yufan Wu, Basri Gülbakan, Lutz Kummer, Christoph Klenk, K. Dane Wittrup, Peer R. E. Mittl, Seymour de Picciotto, Erik Sedlák, Andreas Plückthun, Franziska Zosel, Jendrik Schöppe, Marco Schütz, Gregory A. Newby
Publikováno v:
Journal of Molecular Biology
Fluorescent probes constitute a valuable toolbox to address a variety of biological questions and they have become irreplaceable for imaging methods. Commonly, such probes consist of fluorescent proteins or small organic fluorophores coupled to biolo