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Akademický článek
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Autor:
Tiago Carvalheiro, Marzia Rossato, Marta Cossu, Catherina G.K. Wichers, Lorenzo Beretta, Eleni Chouri, Jonas J.W. Kuiper, Femke Bonte-Minheur, Sandra C Silva-Cardoso, Nila H. Servaas, Anneline C Hinrichs, Timothy R D J Radstake, Aridaman Pandit, Nadia Vazirpanah, Alsya J. Affandi, Maarten van der Kroef, Cornelis P. J. Bekker, Andrea Ottria, Marianne Boes, Sanne Hiddingh
Publikováno v:
Arthritis and Rheumatology. John Wiley and Sons Ltd
ObjectivesTo identify key disease pathways driving conventional dendritic cell (cDC) alterations in Systemic Sclerosis (SSc).MethodsTranscriptomic profiling was performed on peripheral blood CD1c+ cDCs (cDC2s) isolated from 12 healthy donors and 48 S
Autor:
Anthony J. O’Donoghue, Michael C Yoon, Max J. Bedding, Vivian Hook, Pavla Fajtová, Arthur H Tang, Mark Larance, Linfeng Li, Chien-Te Tseng, Stuart Turville, James H. McKerrow, Dustin Pwee, Laura Beretta, Alexander Stoye, Danielle E. Skinner, William H. Gerwick, Anneliese S. Ashhurst, Thomas D. Meek, Anupriya Aggarwal, Aleksandra Drelich, Richard J. Payne
Publikováno v:
bioRxiv
Cathepsin L is a key host cysteine protease utilized by coronaviruses for cell entry and is a promising drug target for novel antivirals against SARS-CoV-2. The marine natural product gallinamide A and several synthetic analogues were identified as p
Publikováno v:
Clinical Reviews in Allergy & Immunology. 63:124-137
Circulating autoantibodies are a key diagnostic tool in autoimmune hepatitis (AIH), being positive in 95% of the cases if tested according to dedicated guidelines issued by the International Autoimmune Hepatitis Group. They also allow the distinction
Autor:
Nico Mitro, Monica Marzagalli, Michela Raimondi, Patrizia Limonta, Giangiacomo Beretta, Patrizia Procacci, Matteo Audano, Fabrizio Fontana, Patrizia Sartori
Publikováno v:
Apoptosis
Abstract Melanoma is an aggressive tumor with still poor therapy outcomes. δ-tocotrienol (δ-TT) is a vitamin E derivative displaying potent anti-cancer properties. Previously, we demonstrated that δ-TT triggers apoptosis in human melanoma cells. H
Autor:
Aleksandra Drelich, Miriam A. Giardini, Pavla Fajtová, Drake M. Mellott, Vivian Hook, Thomas D. Meek, Jason C. Hsu, Demetrios H. Kostomiris, Aaron F. Carlin, Frank M. Raushel, Klaudia I. Kocurek, Jair L. Siqueira-Neto, Zane W. Taylor, Anthony J. O’Donoghue, Felix W Frueh, Jiyun Zhu, Ardala Katzfuss, Chien Te K. Tseng, Sungjun Beck, Hong Wang, Brett L. Hurst, Laura Beretta, Ken Hirata, James H. McKerrow, Alex E. Clark, Linfeng Li, Daniel C Maneval, Danielle E. Skinner, Balachandra Chenna, Vivian Tat, Michael C Yoon
Publikováno v:
ACS Chemical Biology. 16:642-650
Host-cell cysteine proteases play an essential role in the processing of the viral spike protein of SARS coronaviruses. K777, an irreversible, covalent inactivator of cysteine proteases that has recently completed phase 1 clinical trials, reduced SAR
Autor:
Jules Beekwilder, Miguel Ezquerro, Alisdair R. Fernie, Stefano Beretta, M. Victoria Barja, Alessia Fiore, Rumyana Karlova, Elisenda Feixes, Igor Florez-Sarasa, Gianfranco Diretto, Manuel Rodríguez-Concepción
Publikováno v:
Dipòsit Digital de Documents de la UAB
Universitat Autònoma de Barcelona
New Phytologist, 231(1), 255-272
bioRxiv
Digital.CSIC. Repositorio Institucional del CSIC
instname
RiuNet. Repositorio Institucional de la Universitat Politécnica de Valéncia
IRTA Pubpro. Open Digital Archive
Institut de Recerca i Tecnologia Agroalimentàries (IRTA)
New Phytologist 231 (2021) 1
Universitat Autònoma de Barcelona
New Phytologist, 231(1), 255-272
bioRxiv
Digital.CSIC. Repositorio Institucional del CSIC
instname
RiuNet. Repositorio Institucional de la Universitat Politécnica de Valéncia
IRTA Pubpro. Open Digital Archive
Institut de Recerca i Tecnologia Agroalimentàries (IRTA)
New Phytologist 231 (2021) 1
Geranylgeranyl diphosphate (GGPP) produced by GGPP synthase (GGPPS) serves as a precursor for many plastidial isoprenoids, including carotenoids. Phytoene synthase (PSY) converts GGPP into phytoene, the first committed intermediate of the carotenoid
Autor:
Peng Wei, Ying Wang, Donjeta Gjuka, Jing Wang, Jorge A. Marrero, Jingjing Jiao, Laura Beretta, Hashem B. El-Serag, Xiaoling Song, Ilvira M. Khan
Publikováno v:
Cancer Prev Res (Phila)
Novel biomarkers for hepatocellular carcinoma (HCC) surveillance in patients with cirrhosis are urgently needed. We previously identified osteopontin (OPN) as a promising biomarker for the early detection of HCC. This study is to further validate the
Autor:
Andrea Beretta
Publikováno v:
Zeitschrift für romanische Philologie. 137:252-286
My article focuses on the Franco-Italian poem Attila Flagellum Dei, composed by Nicolò da Càsola, an Italian notary, in the second half of the XIV century for the Estensi in Ferrara, in order to celebrate the heroic origins of the family: actually,
Autor:
Daniela Cesana, Anastasia Conti, Eugenio Montini, Stefano Beretta, Riccardo Biavasco, Claudio Doglioni, Serena Scala, Diego Gilioli, Luca Basso-Ricci, Giulio Cavalli, Pierangela Gallina, Maurilio Ponzoni, Raffaella Di Micco, Alessandro Aiuti, Ivan Merelli, Attilio Bondanza, Margherita Norelli, Kety Giannetti, Emanuele Lettera, Lorenzo Dagna
Publikováno v:
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
Activating mutations in the BRAF-MAPK pathway have been reported in histiocytoses, hematological inflammatory neoplasms characterized by multi-organ dissemination of pro-inflammatory myeloid cells. Here, we generate a humanized mouse model of transpl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05652830ea4b45f2383d98efb5f8e1bb