Zobrazeno 1 - 10
of 53
pro vyhledávání: '"Alfredo Castello"'
Autor:
Connor G. G. Bamford, Milagros Rodriguez Collados, Alfredo Castello, Srikeerthana Kuchi, David Robertson, Nardus Mollentze, Sam J. Wilson, Joseph Busby, Arthur Wickenhagen, Douglas G. Stewart, Richard J. Orton, Siddharth Bakshi, Quan Gu, Elena Sugrue, Matthew L. Turnbull, Daniel G. Streicker, Massimo Palmarini, Suzannah J. Rihn, Andrew Shaw, Ana Filipe da Silva, Paul C. D. Johnson, Katherine Smollett
Publikováno v:
PLoS Biology
PLoS Biology, Vol 19, Iss 9, p e3001352 (2021)
PLoS Biology, Vol 19, Iss 9, p e3001352 (2021)
Antiviral defenses can sense viral RNAs and mediate their destruction. This presents a challenge for host cells since they must destroy viral RNAs while sparing the host mRNAs that encode antiviral effectors. Here, we show that highly upregulated int
Autor:
Louisa Iselin, Alan Wainman, Richard M. Parton, Jane A. McKeating, Marko Noerenberg, Mary Kay Thompson, Alfredo Castello, William James, Ilan Davis, Aino I. Järvelin, Daniel Agranoff, Natasha Palmalux, Dalia Gala, Jeffrey Y. Lee, Josh Titlow, Peter A C Wing, Xiaodong Zhuang
SummaryDespite an unprecedented global research effort on SARS-CoV-2, early replication events remain poorly understood. Given the clinical importance of emergent viral variants with increased transmission, there is an urgent need to understand the e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::90c9c0ea5d984a6e3e1055ee23dbf95d
https://doi.org/10.1101/2021.06.29.450133
https://doi.org/10.1101/2021.06.29.450133
Autor:
Fabio T. M. Costa, Paul J. Lehner, Sam J. Wilson, Suzannah J. Rihn, David Robertson, Srikeerthana Kuchi, Quan Gu, Thomas W M Crozier, Alfredo Castello-Palomares, Rute Maria Pinto, Elena Sugrue, Matthew L. Turnbull, Isaric C-Investigators, Colin Loney, Monique Freire Santana, Jay Allan, Luiz Carlos de Lima Ferreira, Spyros Lytras, Antonia Ho, Natalia Cameron-Ruiz, Richard J. Stanton, Ruth F. Jarrett, Vanessa Herder, Arthur Wickenhagen, Innes Jarmson, Bo Wang, Sara Clohisey, Edward Chung Yern Wang, Matthias Marti, Massimo Palmarini, Kenneth Baillie, Marko Noerenberg, Joao Luiz Da Silva Filho, Douglas G. Stewart, Margus Varjak, Edward J. D. Greenwood, Simon Swingler
Cell autonomous antiviral defenses can inhibit the replication of viruses and reduce transmission and disease severity. To better understand the antiviral response to SARS-CoV-2, we used interferon-stimulated gene (ISG) expression screening to reveal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0cd517e51ccb503d025f6bea1c5a2cbb
https://doi.org/10.1101/2021.05.05.21256681
https://doi.org/10.1101/2021.05.05.21256681
Autor:
Ilan Davis, Peter J. Ratcliffe, Alfredo Castello, William James, Jeffrey Y. Lee, Maria Prange-Barczynska, Marko Noerenberg, Jane A. McKeating, Craig Thompson, Senko Tsukuda, Koichi Watashi, Isobel L.A. Argles, Thomas P. Keeley, Sophie B. Morgan, Peter A C Wing, Samvid Kurlekar, Kuan-Ying A. Huang, Xiaodong Zhuang, Timothy S. C. Hinks, Tammie Bishop, Peter Balfe, Emma J. Hodson, Adam Harding
Publikováno v:
Cell Reports
Cell Reports, Vol 35, Iss 3, Pp 109020-(2021)
Cell Reports, Vol 35, Iss 3, Pp 109020-(2021)
COVID-19, caused by the novel coronavirus SARS-CoV-2, is a global health issue with more than 2 million fatalities to date. Viral replication is shaped by the cellular microenvironment and one important factor to consider is oxygen tension, where hyp
Autor:
Natasha Johnson, Berati Cerikan, Shabaz Mohammed, Manuel Garcia-Moreno, Javier Martinez, Christopher J. Neufeldt, Alfredo Castello, Ralf Bartenschlager, Mohamed Kammoun, Jeffrey Y. Lee, Anna Andrejeva, Mirko Cortese, Marko Noerenberg, Honglin Chen, Kathryn S. Lilley, Ilan Davis, Michael L. Knight, Aino I. Järvelin, Ni Shuai, Wael Kamel, Michael J. Deery
Publikováno v:
Molecular Cell
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes COVID-19. SARS-CoV-2 relies on cellular RNA-binding proteins (RBPs) to replicate and spread, although which RBPs control its life cycle remains largely unknown. Here, we employ a mul
Autor:
Natasha Palmalux, Shabaz Mohammed, Louisa Iselin, Wael Kamel, Peter Simmonds, Alfredo Castello
Publikováno v:
trends in biochemical sciences
RNA viruses interact with a wide range of cellular RNA-binding proteins (RBPs) during their life cycle. The prevalence of these host-virus interactions has been highlighted by new methods that elucidate the composition of viral ribonucleoproteins (vR
Autor:
Wael Kamel, Maximilian Hannan, Alfredo Castello, Vincenzo Ruscica, Louisa Iselin, Samantha Moore, Manuel Garcia-Moreno, Javier Martinez, Ilan Davis, Shabaz Mohammed, Marko Noerenberg, Aino I. Järvelin, Natasha Palmalux, Andres Merits
Publikováno v:
bioRxiv
The expansion of tropical mosquito habitats and associated arboviruses is a risk for human health, and it thus becomes fundamental to identify new antiviral strategies. In this study we employ a new approach to elucidate the composition of the ribonu
Autor:
Ralf Bartenschlager, Alfredo Castello, Jeffrey Y. Lee, Berati Cerikan, Ilan Davis, Christopher J. Neufeldt, Honglin Chen, Manuel Garcia-Moreno, Javier Martinez, Kathryn S. Lilley, Anna Andrejeva, Michael J. Deery, Marko Noerenberg, Mirko Cortese, Wael Kamel, Michael L. Knight, Ni Shuai, Aino I. Järvelin, Mohamed Kammoun, Shabaz Mohammed
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes COVID-19. SARS-CoV-2 relies on cellular RNA-binding proteins (RBPs) to replicate and spread, although which RBPs control SARS-CoV-2 infection remains largely unknown. Here, we employ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e4faa151542462c893b9464395431018
https://doi.org/10.1101/2020.11.25.398008
https://doi.org/10.1101/2020.11.25.398008
Autor:
Renier A. L. van der Hoorn, Shabaz Mohammed, Gail M. Preston, Markus Kaiser, Honglin Chen, Farnusch Kaschani, Alfredo Castello, Marcel Bach-Pages, Nattapong Sanguankiattichai, Riccardo Soldan
RNA-binding proteins (RBPs) play critical roles in post-transcriptional gene regulation and are known to contribute to plant immunity. To understand the responses of cellular RBPs to an immune elicitor, we applied RNA interactome capture to Arabidops
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c69409250951f8ae176d721e9f8c2677
https://doi.org/10.1101/2020.09.16.299701
https://doi.org/10.1101/2020.09.16.299701
Publikováno v:
Seminars in Cell & Developmental Biology
Highlights • Proteomic studies have uncovered more than a thousand cellular proteins that are present in the particles of RNA viruses. • Strikingly, nearly four hundred of these are RNA-binding proteins (RBPs). • Several virion-incorporated RBP