Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Adrian Tun Kyi"'
Autor:
Katherine A. Fitzgerald, John M. Asara, Linda K. Nicholson, Tae Ho Lee, George C. Tsokos, Greg Finn, Adrian Tun-Kyi, Michael Nowak, Elliot Israel, Alexander I. Greenwood, Mark A. Exley, Kun Ping Lu, Xiaoxia Li
Publikováno v:
Nature immunology
Toll-like receptors (TLRs) shape innate and adaptive immunity to microorganisms. The enzyme IRAK1 transduces signals from TLRs, but mechanisms for its activation and regulation remain unknown. We found here that TLR7 and TLR9 activated the isomerase
Autor:
Christina Y. Soohoo, Tae Ho Lee, Martin Balastik, Lucia Pastorino, Greg Finn, Gerburg M. Wulf, Xiao Zhen Zhou, Kun Ping Lu, Adrian Tun-Kyi, Jormay Lim, Rong Shi
Publikováno v:
Nature Cell Biology. 11:97-105
The prolyl isomerase Pin1 acts in various cellular processes. It has now been implicated in telomere maintenance by regulating the stability of the telomere binding protein TRF1. Telomeres are essential for maintaining cellular proliferative capacity
Autor:
Leonardo Cavone, Francesca Prignano, Giulia Mariotti, Gianni Gerlini, Adrian Tun-Kyi, Lorenzo Borgognoni, Astrid Parenti, Roberto Caporale, Nicola Pimpinelli, Paola Di Gennaro, Alberto Chiarugi, Riccardo Saccardi
Publikováno v:
The Journal of Immunology. 181:2999-3008
IFN-alpha is a well-known agent for treatment of viral and malignant diseases. It has several modes of actions, including direct influence on the immune system. We investigated IFN-alpha effects on PBMC in terms of dendritic cell (DC) differentiation
Autor:
Shoji Yamaoka, Masahiro Yamamoto, Naoki Yamamoto, Greg Finn, Adrian Tun-Kyi, Akihide Ryo, Kun Ping Lu, Tatsuya Saitoh, Takashi Fujita, Shizuo Akira
Publikováno v:
Nature Immunology. 7:598-605
Recognition of double-stranded RNA activates interferon-regulatory factor 3 (IRF3)-dependent expression of antiviral factors. Although the molecular mechanisms underlying the activation of IRF3 have been studied, the mechanisms by which IRF3 activity
Autor:
Michael Gombert, Bernhard Homey, Curdin Conrad, Adrian Tun-Kyi, Yong-Jun Liu, Frank O. Nestle, Michel Gilliet, Onur Boyman, Günter Burg
Publikováno v:
The Journal of Experimental Medicine
Psoriasis is one of the most common T cell-mediated autoimmune diseases in humans. Although a role for the innate immune system in driving the autoimmune T cell cascade has been proposed, its nature remains elusive. We show that plasmacytoid predendr
Autor:
Nicola Pimpinelli, Gianni Gerlini, Adrian Tun-Kyi, Frank O. Nestle, Christa Dudli, Günter Burg
Publikováno v:
The American Journal of Pathology. 165:1853-1863
CD1 molecules are expressed by antigen-presenting cells such as dendritic cells and mediate primary immune responses to lipids and glycolipids which have been shown to be expressed by various tumors. Glycolipids are expressed by melanoma cells but, d
Autor:
Michel Gilliet, Martin Kleinhans, Marshall E. Kadin, Reinhard Dummer, Guenter Burg, Frank O. Nestle, Adrian Tun-Kyi
Publikováno v:
Blood. 101:1487-1493
Little is known about mechanisms involved in skin-specific homing of cutaneous T-cell lymphoma (CTCL). Chemokine/chemokine receptor interactions have been implicated in the homing of lymphoma cells to various tissue sites. We investigated tissue samp
Publikováno v:
Lung Cancer. 36:151-158
Epithelial cell adhesion molecule (Ep-CAM) derived antigenic peptides have been identified that can be recognized by cytotoxic T lymphocytes (CTL) in a major histocompatibility complex (MHC) class I restricted fashion. Thus, altered expression of Ep-
Dendritic cells (DCs) are potent antigen-presenting cells (1) with wide tissue distribution. They are classified based primarily on their localization: as Langerhans cells when present in the epidermis and as dermal DCs when found in the dermis. DCs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::538a56453a6900c829ccd3dc9ae24712
https://doi.org/10.1385/1-59259-145-0:195
https://doi.org/10.1385/1-59259-145-0:195
Autor:
Mark A. Exley, Ingo G.H. Schmidt-Wolf, Martin G. Sanda, Michael Nowak, Steven P. Balk, Mohammed Simo Arredouani, Adrian Tun-Kyi
Publikováno v:
PLoS ONE
PLoS ONE, Vol 5, Iss 6, p e11311 (2010)
PLoS ONE, Vol 5, Iss 6, p e11311 (2010)
Numerical and functional defects of invariant natural killer T cells (iNKT) have been documented in human and mouse cancers, resulting in a defect in IFN production in several malignancies. iNKT cells recognize glycolipids presented on CD1d molecules