Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Adam Langenbucher"'
Autor:
Krystle A. Lang Kuhs, Daniel L. Faden, Adam Langenbucher, Michael Cullen, James S. Lewis, Michael S. Lawrence, Mia Steinberg, Sara Bass, Joseph Boland, Robert L. Ferris, Lisa Mirabello, Meredith Yeager
Publikováno v:
Carcinogenesis
Human papillomavirus (HPV) positive oropharyngeal squamous cell carcinoma (HPV + OPSCC) is increasing in prevalence in the USA, as are cases of patients with multiple HPV + OPSCCs (mHPV + OPSCC). mHPV + OPSCCs present a unique opportunity to examine
Autor:
Kylie Prutisto Chang, Mari Mino-Kenudson, Alice T. Shaw, Adam Langenbucher, Michael S. Lawrence, Marina Kem, Pranav Gupta, Justin F. Gainor, Isobel J Fetter, Andrew Do, Satoshi Yoda, Jessica J. Lin, Ibiayi Dagogo-Jack, Audris Oh, Marguerite Rooney, Aaron N. Hata, James R. Stone, Ryan B. Corcoran, Emily Chin, Jochen K. Lennerz, Dejan Juric
Publikováno v:
npj Precision Oncology, Vol 4, Iss 1, Pp 1-8 (2020)
NPJ Precision Oncology
NPJ Precision Oncology
Histologic transformation from non-small cell to small cell lung cancer has been reported as a resistance mechanism to targeted therapy in EGFR-mutant and ALK fusion-positive lung cancers. Whether small cell transformation occurs in other oncogene-dr
Autor:
Michael S. Lawrence, Angela G. Fleischman, Kevin Aguirre, Shinho Park, Adam Langenbucher, Ryan B. Corcoran, Lee Zou, Danae Bowen, Pégah Jalili, Rémi Buisson
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Nature Communications
Nature communications, vol 11, iss 1
Nature Communications
Nature communications, vol 11, iss 1
APOBEC3A is a cytidine deaminase driving mutagenesis, DNA replication stress and DNA damage in cancer cells. While the APOBEC3A-induced vulnerability of cancers offers an opportunity for therapy, APOBEC3A protein and mRNA are difficult to quantify in
Autor:
Benjamin Nicholson, Daniel A. Haber, David A. Sweetser, Shyamala Maheswaran, Min-Kyung Choo, Fei Ji, Douglas S. Micalizzi, Nicholas J. Haradhvala, Sooncheol Lee, Adam Langenbucher, Myriam Boukhali, Yasutaka Kato, David B. Sykes, Ruslan I. Sadreyev, Samuel S. Truesdell, Manuel D. Díaz-Muñoz, Roopali Gandhi, Syed I. A. Bukhari, Maria Antonietta Mazzola, Ipsita Dey-Guha, David T. Myers, Michael S. Lawrence, Dongjun Lee, Radhika Raheja, Shobha Vasudevan, Christopher Tiedje, Wilhelm Haas, Jennifer Lombardi-Story
Publikováno v:
Genome Biology, Vol 21, Iss 1, Pp 1-23 (2020)
Genome Biology
Lee, S, Micalizzi, D, Truesdell, S S, Bukhari, S I A, Boukhali, M, Lombardi-Story, J, Kato, Y, Choo, M K, Dey-Guha, I, Ji, F, Nicholson, B T, Myers, D T, Lee, D, Mazzola, M A, Raheja, R, Langenbucher, A, Haradhvala, N J, Lawrence, M S, Gandhi, R, Tiedje, C, Diaz-Muñoz, M D, Sweetser, D A, Sadreyev, R, Sykes, D, Haas, W, Haber, D A, Maheswaran, S & Vasudevan, S 2020, ' A post-transcriptional program of chemoresistance by AU-rich elements and TTP in quiescent leukemic cells ', Genome Biology, vol. 21, no. 1, 33 . https://doi.org/10.1186/s13059-020-1936-4
Genome Biology
Lee, S, Micalizzi, D, Truesdell, S S, Bukhari, S I A, Boukhali, M, Lombardi-Story, J, Kato, Y, Choo, M K, Dey-Guha, I, Ji, F, Nicholson, B T, Myers, D T, Lee, D, Mazzola, M A, Raheja, R, Langenbucher, A, Haradhvala, N J, Lawrence, M S, Gandhi, R, Tiedje, C, Diaz-Muñoz, M D, Sweetser, D A, Sadreyev, R, Sykes, D, Haas, W, Haber, D A, Maheswaran, S & Vasudevan, S 2020, ' A post-transcriptional program of chemoresistance by AU-rich elements and TTP in quiescent leukemic cells ', Genome Biology, vol. 21, no. 1, 33 . https://doi.org/10.1186/s13059-020-1936-4
Background Quiescence (G0) is a transient, cell cycle-arrested state. By entering G0, cancer cells survive unfavorable conditions such as chemotherapy and cause relapse. While G0 cells have been studied at the transcriptome level, how post-transcript
Autor:
Adam Langenbucher, Siang-Boon Koh, Hope S. Rugo, Erica L. Mayer, Lisa A. Carey, Srinivas Vinod Saladi, Lei He, Tiffany A. Traina, Steven J. Isakoff, Vered Stearns, Minetta C. Liu, Michael S. Lawrence, Sridhar Ramaswamy, Nsan Melkonjan, Andrew Schultz, Leif W. Ellisen, Kenneth N. Ross, Karina J. Matissek
Publikováno v:
Koh, S-B, Ross, K, Isakoff, S J, Melkonjan, N, He, L, Matissek, K J, Schultz, A, Mayer, E L, Traina, T A, Carey, L A, Rugo, H S, Liu, M C, Stearns, V, Langenbucher, A, Saladi, S V, Ramaswamy, S, Lawrence, M S & Ellisen, L W 2021, ' RASAL2 Confers Collateral MEK/EGFR Dependency in Chemoresistant Triple-Negative Breast Cancer ', Clinical Cancer Research, vol. 27, no. 17, pp. 4883-4897 . https://doi.org/10.1158/1078-0432.CCR-21-0714
Clin Cancer Res
Clin Cancer Res
Purpose: While chemotherapy remains the standard treatment for triple-negative breast cancer (TNBC), identifying and managing chemoresistant tumors has proven elusive. We sought to discover hallmarks and therapeutically actionable features of refract
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47d584ccaf68267da9eb08c33d1fb8ce
https://research-information.bris.ac.uk/en/publications/1e9956ee-f86f-422d-82c9-c3c9149c2fe8
https://research-information.bris.ac.uk/en/publications/1e9956ee-f86f-422d-82c9-c3c9149c2fe8
Autor:
Krystle A. Lang Kuhs, Michael Cullen, Mia Steinberg, Maisa Pinheiro, Sara Bass, James S. Lewis, Michael S. Lawrence, Daniel L. Faden, Maoxuan Lin, Adam Langenbucher, Meredith Yeager, Joseph Boland, Lisa Mirabello, Robert L. Ferris
Publikováno v:
Viruses, Vol 13, Iss 1666, p 1666 (2021)
Viruses
Volume 13
Issue 8
Viruses
Volume 13
Issue 8
APOBEC (apolipoprotein B mRNA-editing enzyme, catalytic polypeptide-like) is a major mutagenic source in human papillomavirus positive oropharyngeal squamous cell carcinoma (HPV+ OPSCC). Why APOBEC mutations predominate in HPV+OPSCC remains an area o
Autor:
Elad Horwitz, Joanna A. Vuille, Ben S. Wittner, Devon F. Wiley, Xin Hong, Taronish D. Dubash, Shyamala Maheswaran, Kira L. Niederhoffer, Soroush Hajizadeh, Michael S. Lawrence, Shobha Vasudevan, Risa Burr, Linda T. Nieman, Uyen Ho, Adam Langenbucher, Raul Mostoslavsky, Lee Zou, Benjamin Wesley, Richard Y. Ebright, Jia-Min Zhang, Hongshan Guo, Chenyue Lu, Valentine Comaills, Marcus A. Zachariah, Daniel A. Haber, Gabriel Golczer, Brittany A. Reeves, Mehmet Toner
Publikováno v:
Mol Cell
Summary Deregulation of oncogenic signals in cancer triggers replication stress. Immediate early genes (IEGs) are rapidly and transiently expressed following stressful signals, contributing to an integrated response. Here, we find that the orphan nuc
Autor:
Danae Bowen, Ashok S. Bhagwat, Ramin Sakhtemani, Michael S. Lawrence, Adam Langenbucher, Jillian F. Wise, Rémi Buisson, Elodie Bournique, Lee Zou
Publikováno v:
Nature communications, vol 12, iss 1
Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
Nature Communications
APOBEC mutagenesis, a major driver of cancer evolution, is known for targeting TpC sites in DNA. Recently, we showed that APOBEC3A (A3A) targets DNA hairpin loops. Here, we show that DNA secondary structure is in fact an orthogonal influence on A3A s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b2ad5be2d6de7df9ad5881d9103ccb0
https://escholarship.org/uc/item/6hf407s2
https://escholarship.org/uc/item/6hf407s2
Autor:
Ravindra Mylavagnanam, Sridhar Ramaswamy, Elena Zarcaro, Srinivas Vinod Saladi, Andrea Desmond, Murat Yildirim, Varunika Vivekanandan, Michael S. Lawrence, Kenneth N. Ross, Mihriban Karaayvaz-Yildirim, Rebecca E. Silberman, Adam Langenbucher, Leif W. Ellisen, Angelika Amon, Michelle C. Specht, Hiranmayi Ravichandran
Publikováno v:
Science Advances. 6
Women harboring heterozygous germline mutations of BRCA2 have a 50 to 80% risk of developing breast cancer, yet the pathogenesis of these cancers is poorly understood. To reveal early steps in BRCA2-associated carcinogenesis, we analyzed sorted cell
Autor:
Michelle C. Specht, Murat Yildirim, Michael S. Lawrence, Mihriban Karaayvaz, Srinivas Vinod Saladi, Angelika Amon, Adam Langenbucher, Rebecca E. Silberman, Varunika Vivekanandan, Andrea Desmond, Leif W. Ellisen, Sridhar Ramaswamy, Kenneth N. Ross, Ravindra Mylavagnanam, Elena Zarcaro, Hiranmayi Ravichandran
Women harboring heterozygous germline mutations of BRCA2 have a 50-80% risk of developing breast cancer, yet the early pathogenesis of these cancers is poorly understood. We sought to reveal early steps in BRCA2-associated carcinogenesis through anal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7aca1536bb1e9698d683f92a1ea1e17
https://doi.org/10.1101/729301
https://doi.org/10.1101/729301