Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Vincent W. Keng"'
Autor:
Christopher L. Moertel, Amanda L. Halfond, Adrienne L. Watson, Eric P. Rahrmann, David A. Largaespada, Leah K. Anderson, Kyle A. Williams, Andrew D. Greeley, Natasha M. Powell, Namrata N. Damle, Vincent W. Keng, Tilat A. Rizvi, Bryant J. Keller, Margaret H. Collins, Samuel J. Finnerty, Nancy Ratner
Publikováno v:
Oncotarget
Malignant peripheral nerve sheath tumors (MPNSTs) are soft tissue sarcomas that occur spontaneously, or from benign plexiform neurofibromas, in the context of the genetic disorder Neurofibromatosis Type 1 (NF1). The current standard treatment include
Autor:
Yuyu Yu, Xiao Xiao Li, Dewi Kenneth Rowlands, Shi Jie Zhang, Jeffrey C. To, Lilian H. Lo, Vincent W. Keng, Amy P. Chiu
Publikováno v:
Biochemical and Biophysical Research Communications. 515:50-56
The neuromuscular junction (NMJ) is formed by motor nerve terminals, post-junctional muscle membranes, and terminal Schwann cells (SCs). The formation of NMJ requires complex and dynamic molecular interactions. Nerve- and muscle-derived molecules hav
Autor:
He Ning Cui, Xiao Xiao Li, Lilian H. Lo, Shi Jie Zhang, Dewi Kenneth Rowlands, Jeffery C. To, Vincent W. Keng, Amy P. Chiu
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 9, Iss 1, Pp 297-303 (2019)
G3: Genes|Genomes|Genetics
G3: Genes|Genomes|Genetics
The neuromuscular junction (NMJ) consists of three components, namely presynaptic motor neurons, postsynaptic muscle fibers and perisynaptic Schwann cells (PSCs). The role of Schwann cells (SCs) in regulating NMJ structural and functional development
Autor:
Christopher L. Moertel, Adrienne L. Watson, Vincent W. Keng, David A. Largaespada, Natalie K. Wolf, Bernat Gel, Dominic A. Beckmann, Margaret H. Collins, Eduard Serra, Margaret R. Wallace, Aaron L. Sarver, Branden S. Moriarity, Kwangmin Choi, Nancy Ratner, Eric P. Rahrmann
Publikováno v:
Nature genetics
Malignant peripheral nerve sheath tumors (MPNSTs) are sarcomas of Schwann cell lineage origin that occur sporadically or in association with the inherited syndrome neurofibromatosis type 1. To identify genetic drivers of MPNST development, we used th
Autor:
Eric B. Schwartz, Walter J. Jessen, Jianqiang Wu, James R. Fuchs, Yuanshu Zou, Kevin A. T. Silverstein, Jose A. Cancelas, Deanna M. Patmore, Kwangmin Choi, Mi-Ok Kim, Edwin Jousma, Ami V. Patel, David A. Largaespada, Eva Dombi, Gang Huang, Barbara R. Tschida, David E. Levy, Jed J. Kendall, Vincent W. Keng, Robert J. Spinner, Danhua Fan, Nancy Ratner, Anat Stemmer-Rachamimov
Publikováno v:
Cell Reports, Vol 14, Iss 8, Pp 1979-1990 (2016)
SummaryTo identify genes and signaling pathways that initiate Neurofibromatosis type 1 (NF1) neurofibromas, we used unbiased insertional mutagenesis screening, mouse models, and molecular analyses. We mapped an Nf1-Stat3-Arid1b/β-catenin pathway tha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d4cd23be8f1a14cb8ed8e1e19cb857a
https://europepmc.org/articles/PMC4782770/
https://europepmc.org/articles/PMC4782770/
Autor:
David E. Levy, Jose A. Cancelas, Eva Dombi, Deanna M. Patmore, Edwin Jousma, Robert J. Spinner, Eric B. Schwartz, Vincent W. Keng, David A. Largaespada, Danhua Fan, Anat Stemmer-Rachamimov, James R. Fuchs, Nancy Ratner, Mi-Ok Kim, Jed K. Kendall, Kwangmin Choi, Yuanshu Zou
To identify genes and signaling pathways that drive peripheral nerve tumor initiation and growth beyond the Ras-MAPK pathway we used unbiased insertional mutagenesis screening. We identified Stat3 as a potential driver of Neurofibromatosis type 1 neu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::435f722f3bed806530e4ff2754e0d32b
https://europepmc.org/articles/PMC4218479/
https://europepmc.org/articles/PMC4218479/
Publikováno v:
Bioscience, biotechnology, and biochemistry. 67(6)
M2-type pyruvate kinase (M2-PK) mRNA is produced from the PKM gene by an alternative RNA splicing in adipocytes. We found that insulin increased the level of M2-PK mRNA in 3T3-L1 adipocytes in both time- and dose-dependent manners. This induction did