Zobrazeno 1 - 10
of 208
pro vyhledávání: '"Dan Li"'
Publikováno v:
Molecular Oncology. 16:1200-1217
Phosphatase and tensin homolog deleted on chromosome ten (PTEN) is a dual lipid and protein phosphatase. Multiple mechanisms contributing to the regulation of PTEN levels have been identified thus far, including post-translational modifications, epig
Autor:
Hsuan-An Chen, Samuel Haywood, Ninghui Mao, Neal Rosen, Zeda Zhang, Brett S. Carver, Charles L. Sawyers, Dan Li, Qing Chang, Andrew C. Hsieh, Elisa de Stanchina, Xiaoping Chen, Danielle Choi, Yu Chen, Young Sun Lee, Cindy Lee, Aura Agudelo Rivera, Guotai Xu
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Nature Communications
Nature Communications
Previous studies have suggested that PTEN loss is associated with p110β signaling dependency, leading to the clinical development of p110β-selective inhibitors. Here we use a panel pre-clinical models to reveal that PI3K isoform dependency is not g
Autor:
Xu Zhan, Xueyu Dai, Qianru Huang, Hao Cheng, Xinnan Liu, Bin Li, Rui Liang, Dan Li, Na Tian, Xu Liu
Publikováno v:
FEBS Letters. 595:1962-1974
Regulatory T cells (Tregs) are indispensable for the maintenance of immunological self-tolerance and homeostasis. Heterogeneous nuclear ribonucleoprotein A1 (hnRNPA1) is required for optimal Treg induction. Here, we reveal that human-induced Tregs (i
Publikováno v:
Cell Death and Disease, Vol 12, Iss 6, Pp 1-17 (2021)
Cell Death & Disease
Cell Death & Disease
Background Papillary thyroid cancer (PTC) is the most common type of cancer of the endocrine system. Long noncoding RNAs (lncRNAs) are emerging as a novel class of gene expression regulators associated with tumorigenesis. Through preexisting database
Autor:
Wanhua Xie, Yang Chen, Yaowu Zheng, Yuntao Zhang, Mingjun San, Mingyue Zhao, Anlan Yang, Dan Li, Jing Zhang, Xuechao Feng, Xiaodan Lu
Publikováno v:
Cell Death and Disease, Vol 12, Iss 6, Pp 1-13 (2021)
Cell Death & Disease
Cell Death & Disease
Oxytocin receptor (OXTR) is involved in social behaviors, thermoregulation, and milk ejection, yet little is known about its role in breast cancer. To investigate the role of OXTR in mammary gland development and tumorigenesis, a transgenic mouse mod
Publikováno v:
Journal of Pharmacy and Pharmacology. 73:1023-1032
Objectives This study aimed to explore whether icarrin (ICA) can protect cardiomyocytes from hypertension-induced damage by inhibiting endoplasmic reticulum stress (ERS). Methods Spontaneously hypertensive rats (SHRs) were orally administered water o
Publikováno v:
Journal of Bioenergetics and Biomembranes. 53:295-305
Lung cancer, the most concerning malignancy worldwide and one of the leading causes of cancer-related deaths. Growing evidence indicates that Angiomotin (Amot)-p130 plays an important role in types of cancer, including breast cancer and gastric cance
Autor:
Yingchun Song, Yali Han, Dan Li, Junyu Tong, Wen Jiang, Xiaqing Yu, Simin Liu, Tingting Qiao, Zhongwei Lv
Publikováno v:
Cytogenetic and Genome Research. 161:382-394
Embryonal carcinoma (EC) and seminoma (SE) are both derived from germ cell neoplasia in situ but show big differences in growth patterns and clinical prognosis. Epigenetic regulation may play an important role in the development of EC and SE. This st
Publikováno v:
American Journal of Cancer Prevention. 8:7-12
The Notch signaling pathway is a fundamental intercellular signaling system that regulates cell fate decisions in terms of proliferation and differentiation in multiple tissues. Abnormal activation of Notch1 signaling pathway leads to a variety of di
Autor:
Mengmeng Zhuang, Dan Li, Pan Zhang, Cuijie Li, Peisheng Jin, Haijun Chen, Yong Sun, Yuan Sun, Bo Zhu, Ye Li, Qingwei Cui, Zhaofan Xia, Hao Yan, Wenwen Zhang, Juan Yang
Publikováno v:
Journal of Cellular Physiology. 236:2881-2892
Intestinal mucosal injury is one of the most significant complications of burns. In our previous study, it was found that autophagy could alleviate burn-induced intestinal injury, but the underlying mechanisms are still unclear. Irregular expression