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pro vyhledávání: '"Ernest S. Smith"'
Autor:
Mark Paris, Alan S. Jonason, Alan Howell, Ekaterina Klimatcheva, He Huang, Maria Scrivens, Laurie A. Winter, Christine Reilly, Renee Kirk, Ernest S. Smith, Jennifer Seils, Sebold Torno, Loretta Mueller, Holm Bussler, Maurice Zauderer, John E. Leonard, Terrence L. Fisher, Tracy Pandina, Leslie Balch, Elizabeth E. Evans
Publikováno v:
mAbs
Semaphorin 4D (SEMA4D or CD100) is a member of the semaphorin family of proteins and an important mediator of the movement and differentiation of multiple cell types, including those of the immune, vascular, and nervous systems. Blocking the binding
Publikováno v:
Oncoimmunology
Semaphorin 4D is highly expressed at the invasive tumor margin and acts as a guidance molecule, restricting movement of tumoricidal immune cells into the tumor microenvironment. We recently showed that antibody neutralization of SEMA4D augmented acti