Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Gilles Gasser"'
Autor:
Abdallah Ladaycia, Gilles Gasser, Ursula Rothlisberger, François Mouvet, Jennifer Keiser, Valentin Buchter, Yih Ching Ong, Elise Lepeltier
Schistosomiasis is a disease of poverty affecting millions of people. Praziquantel (PZQ), with its strengths and weaknesses, is the only treatment available. We previously reported 3 lead compounds derived from oxamniquine (OXA), an old antischistoso
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10ffea96bbdf24cd27fbb527353cf21e
https://hal.archives-ouvertes.fr/hal-03645191
https://hal.archives-ouvertes.fr/hal-03645191
Autor:
Gilles Gasser, François Mouvet, Ursula Rothlisberger, Abdallah Ladaycia, Yih Ching Ong, Jennifer Keiser, Valentin Buchter, Elise Lepeltier
Publikováno v:
Chemistry (Weinheim an der Bergstrasse, Germany). 26(66)
Schistosomiasis is a disease of poverty affecting millions of people. Praziquantel (PZQ), with its strengths and weaknesses, is the only treatment available. We previously reported findings on three lead compounds derived from oxamniquine (OXA), an o
Autor:
Jennifer Keiser, Yan Lin, Nicoleta Anghel, Johannes Karges, Eric Manoury, Joachim Müller, Rafika Bouchene, Andrew Hemphill, Kevin Cariou, Olivier Blacque, Sarah Keller, Gilles Gasser, Robin B. Gasser, Yih Ching Ong, Aya C Taki
Helminthiases, a group of neglected tropical diseases, affect more than one billion people mainly in tropical and subtropical regions. Albendazole (ABZ) is a broad‐spectrum anthelmintic recommended by the World Health Organisation (WHO). However, d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40bab2f66acd4f84b2e4956006c6db92
https://doi.org/10.26434/chemrxiv.11982180
https://doi.org/10.26434/chemrxiv.11982180
Autor:
Kevin Cariou, Eric Manoury, Johannes Karges, Andrew Hemphill, Cécile Häberli, Robin B. Gasser, Yan Lin, Rafika Bouchene, Gilles Gasser, Joachim Müller, Aya C Taki, Jennifer Keiser, Sarah Keller, Nicoleta Anghel, Olivier Blacque, Yih Ching Ong
Publikováno v:
Dalton Transactions
Dalton Transactions, 2020, 49 (20), pp.6616-6626. ⟨10.1039/d0dt01107j⟩
Dalton Transactions, Royal Society of Chemistry, 2020, 49 (20), pp.6616-6626. ⟨10.1039/d0dt01107j⟩
Dalton Transactions, 2020, 49 (20), pp.6616-6626. ⟨10.1039/d0dt01107j⟩
Dalton Transactions, Royal Society of Chemistry, 2020, 49 (20), pp.6616-6626. ⟨10.1039/d0dt01107j⟩
International audience; Helminthiases, a group of neglected tropical diseases, affect more than one billion people mainly in tropical and subtropical regions. Moreover, major intestinal protozoa have a significant impact on global public health. Albe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a3639e05c4d5fd37a2595340aee2503
https://hal.science/hal-02555378
https://hal.science/hal-02555378
Autor:
Saonli Roy, Gilles Gasser, Jennifer Keiser, Jeannine Hess, Malay Patra, Bernhard Spingler, Gordana Panic, Luciano Mastrobuoni
Publikováno v:
ACS Infectious Diseases. 3:645-652
Schistosomiasis is a parasitic disease that affects more than 250 million people annually, mostly children in poor, tropical, rural areas. Only one treatment (praziquantel) is available, putting control efforts at risk should resistance occur. In pur
Autor:
Gilles Gasser, Jeannine Hess, Jennifer Keiser, Faustine d'Orchymont, Lea Gemperle, Gordana Panic, Marta Jakubaszek
Publikováno v:
MedChemComm
MedChemComm, Royal Society of Chemistry, 2018, 9 (11), pp.1905-1909. ⟨10.1039/C8MD00396C⟩
MedChemComm, Royal Society of Chemistry, 2018, 9 (11), pp.1905-1909. ⟨10.1039/C8MD00396C⟩
International audience; We present the design, synthesis, characterization and biological evaluation of new ferrocenyl and ruthenocenyl derivatives of the organic antimalarial mefloquine, a drug also known for its antischistosomal activity. The two m
Autor:
Murray N. Robertson, Noemi Cowan, Katrin Ingram-Sieber, Matthew H. Todd, Jennifer Keiser, Claudia Meli, Gilles Gasser, Malay Patra, Isabel Meister
Publikováno v:
Antimicrobial Agents and Chemotherapy. 58:5466-5472
A racemic mixture of R and S enantiomers of praziquantel (PZQ) is currently the treatment of choice for schistosomiasis. Though the S enantiomer and the metabolites are presumed to contribute only a little to the activity of the drug, in-depth side-b
Autor:
Bernhard Spingler, Malay Patra, Katrin Ingram, Robin B. Gasser, Vanessa Pierroz, Jennifer Keiser, Gilles Gasser, Stefano Ferrari
Publikováno v:
CHEMISTRY-A EUROPEAN JOURNAL
The antischistosomal effect of two [(η(6)-praziquantel)Cr(CO)(3)] derivatives was investigated. The compounds (see figure: Cr purple, N blue, O red) were prepared in a one-step procedure from commercially available praziquantel. Both derivatives sho
Publikováno v:
Parasites & Vectors
Background Schistosomiasis is a neglected tropical disease and drug-repurposing is a useful strategy to fill its exhausted drug development pipeline. The ferrocenyl analogue of chloroquine, ferroquine, is an antimalarial in late-stage drug developmen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e01efdefc66c0290437dfbd362312318
https://edoc.unibas.ch/34464/
https://edoc.unibas.ch/34464/
Autor:
Stefano Ferrari, Gilles Gasser, Bernhard Spingler, Jennifer Keiser, Vanessa Pierroz, Katrin Ingram, Malay Patra
Publikováno v:
Journal of medicinal chemistry
The design, synthesis and biological evaluation of eighteen ferrocenyl derivatives (4A-12A and 4B-12B) of the most-well known drug against schistosomiasis, namely praziquantel (PZQ), are reported. These compounds which have been all isolated as racem
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f73b8f1991c2dc8844b8862bf659aa40