Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Morris, D."'
Autor:
Ian E. Krop, Warren P. Mason, Samuel C. Blackman, Tina Guthrie, Andrey Loboda, Cong Chen, Morris D. Groves, Steven J. Freedman, Maxine Giannotti, Jared Lunceford, Robert A. Beckman, Prakash Chinnaiyan, Santosh Kesari, Jeremy Hing, Patricia LoRusso, Tim Demuth, James Watters, Alexei A. Podtelezhnikov, Nicholas Butowski, Patrick Y. Wen
Publikováno v:
Journal of Clinical Oncology. 30:2307-2313
Purpose Aberrant Notch signaling has been implicated in the pathogenesis of many human cancers. MK-0752 is a potent, oral inhibitor of γ-secretase, an enzyme required for Notch pathway activation. Safety, maximum-tolerated dose, pharmacokinetics (PK
Autor:
Xiao Hui Diao, Kenneth A. Feathergill, Donald P. Waller, Betsy Herold, William F. Rencher, Calvin J. Chany, Lourens J.D. Zaneveld, Morris D. Cooper, Robert A. Anderson, Gustavo F. Doncel
Publikováno v:
Biology of Reproduction. 66:886-894
Host cell infection by sexually transmitted disease (STD)-causing microbes and fertilization by spermatozoa may have some mechanisms in common. If so, certain noncytotoxic agents could inhibit the functional activity of both organisms. High molecular
Publikováno v:
Biochemical Pharmacology. 55:749-756
S -Methyl N , N -diethylthiolcarbamate sulfoxide (DETC-MeSO) and sulfone (DETC-MeSO 2 ) both inhibit rat liver low K m aldehyde dehydrogenase (ALDH 2 ) in vitro and in vivo (Nagendra et al ., Biochem Pharmacol 47: 1465–1467, 1994). DETC-MeSO has be
Autor:
Xiangyue Newby, S. Ningaraj Nagendra, Kathleen Davis, Jang-Yen Wu, Morris D. Faiman, John V. Schloss
Publikováno v:
Journal of Biological Chemistry. 272:24247-24251
S-Methyl-N,N-diethylthiolcarbamate sulfoxide (DETC-MeSO), a metabolite of the drug disulfiram, is a selective carbamoylating agent for sulfhydryl groups. Treatment of glutamate receptors isolated from mouse brain with DETC-MeSO blocks glutamate bindi
Autor:
Morris D. Faiman, Bruch W. Hart
Publikováno v:
Biochemical Pharmacology. 49:157-163
S-Methyl N,N-diethylthiolcarbamate (DETC-Me) is a metabolite formed during the bioactivation of disulfiram. The formation of its corresponding sulfoxide, S-methyl N,N-diethylthiolcarbamate sulfoxide (DETC-MeSO), from DETC-Me is required for low Km mi
Autor:
Morris D. Faiman, Bruce W. Hart
Publikováno v:
Alcoholism: Clinical and Experimental Research. 18:340-345
S-methyl N,N-diethylthiolcarbamate sulfoxide (DETC-MeSO) is proposed to be the metabolite of disulfiram responsible for the in vivo inhibition of liver low Km, aldehyde dehydrogenase (ALDH) in the rat. Studies were conducted in male Sprague-Dawley ra
Publikováno v:
Biochemical Pharmacology. 46:2291-2297
Disulfiram is bioactivated to S-methyl N,N-diethylthiolcarbamate sulfoxide (DETC-MeSO), the metabolite proposed to be responsible for the action of disulfiram as an aldehyde dehydrogenase inhibitor. This bioactivation process includes a reduction, an
Autor:
Morris D. Faiman, Bruce W. Hart
Publikováno v:
Biochemical Pharmacology. 46:2285-2290
Diethyldithiocarbamate (DDTC), diethyldithiocarbamate methyl ester (DDTC-Me), S-methyl N,N-diethylthiolcarbamate (DETC-Me) and S-methyl N,N-diethylthiolcarbamate sulfoxide (DETC-MeSO) are all metabolites of disulfiram. All inhibit rat liver low Km al
Autor:
Bruce W. Hart, Morris D. Faiman
Publikováno v:
Biochemical Pharmacology. 43:403-406
In summary, these data provide the first evidence that DETC-MeSO is a natural metabolite of disulfiram, and a potent inhibitor of rat liver mitochondrial low Km ALDH both in vitro and in vivo. It is therefore proposed that, based upon evidence to dat
Autor:
Jeffrey J. Yourick, Morris D. Faiman
Publikováno v:
Biochemical Pharmacology. 42:1361-1366
In humans and animals, disulfiram produces a disulfiram-ethanol reaction after an ethanol challenge, the basis of which is the inhibition of liver aldehyde dehydrogenase (ALDH). Disulfiram and the metabolites diethyldithiocarbamate (DDTC), diethyldit