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of 62
pro vyhledávání: ''
Autor:
Nicholas C. Wu, Xueyong Zhu, Marit J. van Gils, Jakob Kreye, Chang-Chun D Lee, Linghang Peng, Hejun Liu, Meng Yuan, Abigail M. Jackson, Dennis R. Burton, Andrew B. Ward, Rogier W. Sanders, David Nemazee, S. Momsen Reincke, Harald Prüss, Ian A. Wilson, Deli Huang
Publikováno v:
Science 373(6556), 818-823 (2021). doi:10.1126/science.abh1139
bioRxiv
article-version (status) pre
article-version (number) 1
Science, 373(6556), 818-823. American Association for the Advancement of Science
Science (New York, N.y.)
bioRxiv
article-version (status) pre
article-version (number) 1
Science, 373(6556), 818-823. American Association for the Advancement of Science
Science (New York, N.y.)
The protective efficacy of neutralizing antibodies (nAbs) elicited during natural infection with SARS-CoV-2 and by vaccination based on its spike protein has been compromised with emergence of the recent SARS-CoV-2 variants. Residues E484 and K417 in
Autor:
Amélie Fradet-Turcotte, Daniel Durocher, Natasha Chaudhary, Anne Margriet Heijink, Salomé Adam, Sylvie M. Noordermeer, Alana Sherker
Publikováno v:
EMBO Reports, 22(12). WILEY
EMBO Reports
EMBO Reports
The tumor suppressor BRCA1 accumulates at sites of DNA damage in a ubiquitin‐dependent manner. In this work, we revisit the role of RAP80 in promoting BRCA1 recruitment to damaged chromatin. We find that RAP80 acts redundantly with the BRCA1 RING d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f77b907f13feee402844efe9db9b476
https://doi.org/10.15252/embr.202153679
https://doi.org/10.15252/embr.202153679
Autor:
Amanda Heslegrave, Lucía Chávez-Gutiérrez, Josef Pannee, Helen Rice, Imogen Swift, Antoinette O'Connor, Jennifer M. Nicholas, Emily Abel, Nanet Willumsen, Henrik Zetterberg, Simon Mead, Selina Wray, Nick C. Fox, Charles Arber, Chris Frost, James M. Polke, Erik Portelius, Kaj Blennow, Philip S.J. Weston, Teresa Poole, Natalie S. Ryan
Publikováno v:
Brain
In vitro studies of autosomal dominant Alzheimer’s disease implicate longer amyloid-β peptides in disease pathogenesis; however, less is known about the behaviour of these mutations in vivo. In this cross-sectional cohort study, we used liquid chr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb18fa743001979676e88b0dddc7cfea
https://lirias.kuleuven.be/handle/123456789/679509
https://lirias.kuleuven.be/handle/123456789/679509
Autor:
Rachel A. DeWeerd, Ariel S. Dineen, Benjamin A. Garcia, Abby M. Green, Katarzyna Kulej, David R. O'Leary, Matthew D. Weitzman, Ava R Hansen, Katharina E. Hayer, Julia H. Szeto
Publikováno v:
EMBO Rep
The APOBEC3 cytidine deaminases are implicated as the cause of a prevalent somatic mutation pattern found in cancer genomes. The APOBEC3 enzymes act as viral restriction factors by mutating viral genomes. Mutation of the cellular genome is presumed t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d6bf5b74d570952f2f247ca552394f3
https://europepmc.org/articles/PMC8419680/
https://europepmc.org/articles/PMC8419680/
Autor:
Elaine R. Mardis, Daniel C. Koboldt, James Fitch, Katherine E. Miller, Christopher R. Pierson, Sean McGrath, Mai-Lan Ho, Tracy A. Bedrosian, Vincent Magrini, Summer R. Fair, Adam P. Ostendorf, Saranga Wijeratne, Jeffrey R. Leonard, Jocelyn M Bush, Kristen M. Leraas, Mark E. Hester, Wesley Schwind, Richard K. Wilson, Erin Crist, Ammar Shaikhouni, Anthony R. Miller
Publikováno v:
Brain
Phosphatase and tensin homologue (PTEN) regulates cell growth and survival through inhibition of the mammalian target of rapamycin (MTOR) signalling pathway. Germline genetic variation of PTEN is associated with autism, macrocephaly and PTEN hamartom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05d0aade759fdba741ebaa7b9e0b8965
https://europepmc.org/articles/PMC8634064/
https://europepmc.org/articles/PMC8634064/
Autor:
Miha Modic, Jamie S. Mitchell, Jacob Neeves, Jernej Ule, Linda Greensmith, Raphaëlle Luisier, Doaa M Taha, Jia Newcombe, Ione Meyer, Giulia E. Tyzack, Rickie Patani, Nicholas M. Luscombe
Publikováno v:
Brain
See Vidal and Atkin (doi:10.1093/brain/awz256) for a scientific commentary on this article. ALS remains incurable due to an incomplete understanding of its molecular pathogenesis. Tyzack, Luisier et al. report that FUS protein, previously thought to
Autor:
Oude Munnink, Bas B, Sikkema, Reina S, Nieuwenhuijse, David F, Molenaar, Robert Jan, Munger, Emmanuelle, Molenkamp, Richard, van der Spek, Arco, Tolsma, Paulien, Rietveld, Ariene, Brouwer, Miranda, Bouwmeester-Vincken, Noortje, Harders, Frank, Hakze-van der Honing, Renate, Wegdam-Blans, Marjolein C A, Bouwstra, Ruth J, GeurtsvanKessel, Corine, van der Eijk, Annemiek A, Velkers, Francisca C, Smit, Lidwien A M, Stegeman, Arjan, van der Poel, Wim H M, Koopmans, Marion P G, Sub GZ Herkauwer, FAH GZ pluimvee, dFAH I&I, IRAS OH Epidemiology Microbial Agents, dIRAS RA-I&I RA, FAH veterinaire epidemiologie, dFAH AVR
Publikováno v:
Science, 371(6525), 172-177. American Association for the Advancement of Science
Science 6525 (2021)
Science (New York, N.y.)
Science
Science, 6525, 172-177
Science (New York, N.Y.), 371(6525), 172. American Association for the Advancement of Science
Science 6525 (2021)
Science (New York, N.y.)
Science
Science, 6525, 172-177
Science (New York, N.Y.), 371(6525), 172. American Association for the Advancement of Science
Two-way transmission on mink farms Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a zoonotic virus—one that spilled over from another species to infect and transmit among humans. We know that humans can infect other animals with SA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fddc2d6a6019f6a0d2c220e8fc4ecfc0
https://pure.eur.nl/en/publications/fecd7c64-a441-4f5f-b6f3-34fc4f9468dc
https://pure.eur.nl/en/publications/fecd7c64-a441-4f5f-b6f3-34fc4f9468dc
Autor:
Allison J. Greaney, Tyler N. Starr, Jesse D. Bloom, Manish Chandra Choudhary, Jonathan Z. Li, Adam S. Dingens, Amin Addetia, William W. Hannon
Publikováno v:
bioRxiv
article-version (status) pre
article-version (number) 1
Science (New York, N.y.)
Science
article-version (status) pre
article-version (number) 1
Science (New York, N.y.)
Science
Mapping antibody escape in SARS-CoV-2 Several antibodies are in use or under development as therapies to treat COVID-19. As new severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants emerge, it is important to predict whether they will
Autor:
Jari Häkkinen, Cecilia Hegardt, Niklas Loman, Johan Vallon-Christersson, Lisa Rydén, Anthony M. George, Christian Brueffer, Christer Larsson, Lao H. Saal, Christof Winter, Sergii Gladchuk, Martin Malmberg, Yilun Chen, Åke Borg, Anna Ehinger
Publikováno v:
EMBO Molecular Medicine
EMBO Molecular Medicine, Vol 12, Iss 10, Pp n/a-n/a (2020)
EMBO Molecular Medicine, Vol 12, Iss 10, Pp n/a-n/a (2020)
Breast cancer is a disease of genomic alterations, of which the panorama of somatic mutations and how these relate to subtypes and therapy response is incompletely understood. Within SCAN‐B (ClinicalTrials.gov: NCT02306096), a prospective study elu
Autor:
Virginia Phillips, Rosa Rademakers, Aamir Zuberi, Matt Baker, John D. Fryer, Mieu Brooks, Dennis W. Dickson, Xiaolai Zhou, Ariston L. Librero, Guojun Bu, Cathleen M. Lutz, Shunsuke Koga, Tammee M. Parsons, Monica Castanedes-Casey, Aishe Kurti, Peizhou Jiang
Publikováno v:
EMBO reports
EMBO Rep
EMBO Rep
Progranulin (PGRN) and transmembrane protein 106B (TMEM106B) are important lysosomal proteins implicated in frontotemporal lobar degeneration (FTLD) and other neurodegenerative disorders. Loss‐of‐function mutations in progranulin (GRN) are a comm