Zobrazeno 1 - 10
of 629
pro vyhledávání: '"35"'
Autor:
Mark Vermeulen, Esmeralda van der Helm, Jort Vellinga, Benoit Christophe Stephan Callendret, Marina Koning, Jan Serroyen, Maria Grazia Pau, Kerstin Wunderlich, Roland Zahn, Hanneke Schuitemaker, Dirk Spek, Adile Gecgel, Barbara Petronella Sanders, Jerome Custers, Marija Vujadinovic, Masha Stalknecht, Karin de Boer
Publikováno v:
Human gene therapy, 29(3), 337-351. Mary Ann Liebert Inc.
Genetic vaccines based on replication-incompetent adenoviral (AdV) vectors are currently in clinical development. Monovalent AdV vectors express one antigen from an expression cassette placed in most cases in the E1 region. For many vaccines, inclusi
Autor:
Angelique A. C. Lemckert, Jos M. Grimbergen, Irma Damen, Marco G. Cecchini, Germaine Penders, Niels Helmus, David Zuijdgeest, Michelle van Meerendonk, Wouter Koudstaal, Olga J.A.E Ophorst, Abraham Bout, Richard van Rijnsoever, Jaap Goudsmit, Antoinette Wetterwald, Björn F. Koel, Eric Hartkoorn, Marie-Pierre de Béthune, Ronald Vogels, Stefan Kostense, Laura Panitti, Mieke Caroline Sprangers, Menzo J. E. Havenga, Paul H.A. Quax
Publikováno v:
Journal of virology, 77(15), 8263-8271. American Society for Microbiology
Journal of Virology, 15, 77, 8263-8271
Journal of Virology, 15, 77, 8263-8271
Replication-deficient human adenovirus type 5 (Ad5) can be produced to high titers in complementing cell lines, such as PER.C6, and is widely used as a vaccine and gene therapy vector. However, preexisting immunity against Ad5 hampers consistency of
Autor:
Pengju Li, Xiangrui Li, Yuanyuan Liang, Yuhua Li, Zhenchao Zhang, Xiaoxu Nan, Qingqing Liu, Gaigai Hong, Qing Xie, Shuai Wang
Publikováno v:
Veterinary parasitology. 260
Toxoplasma gondii rhoptry proteins (TgROPs) have been considered the main targets and indicator molecules for immune diagnosis and prophylaxis because they present during the initial process of invasion. The aim of this study was to evaluate the prot
Autor:
Roland Zahn, Jan Serroyen, Esmeralda van der Helm, Hanneke Schuitemaker, Jerome Custers, Marija Vujadinovic, Lars Vorthoren, Nadine C. Salisch, Harmjan Kuipers, Jort Vellinga, Dirk Spek
Publikováno v:
PLoS ONE, Vol 12, Iss 3, p e0174728 (2017)
PLoS ONE
PLoS ONE
Durable protection against complex pathogens is likely to require immunity that comprises both humoral and cellular responses. While heterologous prime-boost regimens based on recombinant, replication-incompetent Adenoviral vectors (AdV) and adjuvant
Autor:
Fuminori Sakurai, Takako Ichinose, Tomoko Yamaguchi, Kazuko Nakashima, Kenji Kawabata, Hiroyuki Mizuguchi, Takao Hayakawa
Publikováno v:
Journal of Controlled Release. 148:212-218
Recently, much attention has focused on replication-incompetent adenovirus (Ad) vectors containing fiber proteins derived from species B Ad serotype 35 (Ad35) (Ad5F35) and Ad vectors fully constructed from Ad35 as vaccine vectors expressing antigens.
Autor:
Christine C. Yokoyama, Nicholas N. Jarjour, Anshu P. Gounder, Adrianus C. M. Boon, Brian T. Edelson, Traci L. Bricker
Publikováno v:
PLoS Pathogens, Vol 14, Iss 4, p e1007001 (2018)
PLoS Pathogens
PLoS Pathogens
Pro-inflammatory cytokinemia is a hallmark of highly pathogenic H5N1 influenza virus (IAV) disease yet little is known about the role of host proteins in modulating a pathogenic innate immune response. The host Interferon Induced Protein 35 (Ifi35) h
Autor:
Shannon McGrath, Joe Cohen, Marie-Claude Dubois, Patrice M. Dubois, Jerome Custers, Maria Grazia Pau, V. Ann Stewart, Michelle Cobb, Jaap Goudsmit, Jack Komisar, Joseph P. Shott, Kent E. Kester, D. Gray Heppner, Olga J.A.E Ophorst, Marie-Ange Demoitié
Publikováno v:
Vaccine, 26(23), 2818-2823. Elsevier BV
Falciparum malaria vaccine candidates have been developed using recombinant, replication-deficient serotype 5 and 35 adenoviruses (Ad5, Ad35) encoding the Plasmodium falciparum circumsporozoite surface protein (CSP) (Ad5.CS, Ad35.CS) (Crucell Holland
Publikováno v:
YAKUGAKU ZASSHI. 126:1013-1019
Recombinant Adenovirus (Ad) vectors are considered to be a promising gene delivery vehicle of high utility because they are easy to construct, can be produced at high titers, and efficiently transduce various types of cells. Ad vectors commonly used
Autor:
Angelique A. C. Lemckert, Menzo J. E. Havenga, Shawn M. Sumida, Angela Carville, Jaap Goudsmit, Diana M. Truitt, Peter Abbink, Ling Shen, Diana M. Lynch, Darci A. Gorgone, Keith G. Mansfield, Michelle A. Lifton, Dan H. Barouch, Anjali Nanda, Michael G. Kishko, Bonnie A. Ewald
Publikováno v:
Journal of virology, 79(22), 14161-14168. American Society for Microbiology
Preexisting immunity to adenovirus serotype 5 (Ad5) has been shown to suppress the immunogenicity of recombinant Ad5 (rAd5) vector-based vaccines for human immunodeficiency virus type 1 (HIV-1) in both preclinical studies and clinical trials. A poten
Autor:
K-Q Xin, N Jounai, K Someya, K Honma, H Mizuguchi, S Naganawa, K Kitamura, T Hayakawa, S Saha, F Takeshita, K Okuda, M Honda, D M Klinman
Publikováno v:
Gene Therapy. 12:1769-1777
Immunization involving a DNA vaccine prime followed by an adenovirus type 5 (Ad5) boost elicited a protective immune response against SHIV challenge in monkeys. However, the hepatocellular tropism of Ad5 limits the safety of this viral vector. This s