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pro vyhledávání: '"35"'
Autor:
Octavio-Gamaliel Aztatzi-Aguilar, José-Antonio Arias-Montaño, Andrea De Vizcaya-Ruiz, Francisco García-Sierra, María-de-los-Angeles Andrade-Oliva
Publikováno v:
Environmental Toxicology and Pharmacology. 60:58-65
Male Sprague-Dawley rats (8–9 weeks-old) were exposed for three days (acute exposure) or eight weeks (subchronic exposure) to purified air or concentrated ambient fine particles, PM2.5 (≤2.5 μm; 15 to 18-fold of ambient air; 370–445 μg/m3). I
Publikováno v:
Antimicrobial Agents and Chemotherapy
We determined the comparative activity of SMT19969 (SMT) against 162 strains representing 35 well-characterized Clostridium species in clusters I to XIX and 13 Clostridium species that had no 16S rRNA match. SMT MICs ranged from 0.06 to >512 μg/ml a
Publikováno v:
The Pharmacogenomics Journal. 9:274-282
Cytochrome P450 2A6 (CYP2A6) is the primary human enzyme involved in nicotine metabolism. The objective of this study was to characterize two nonsynonymous single nucleotide polymorphisms in CYP2A6(*)24, 594GC (Val110Leu) and 6458AT (Asn438Tyr). We d
[C-11]WIN 35, 428 (WIN), a cocaine analog that binds to the dopamine transporter (DAT), and positron emission tomography (PET) were used to evaluate the potential neuroprotective effects of dizocilpine (MK-801)on methamphetamine (MeAmp) induced neuro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a41c0c0ef9179d2d7b856a878c31fba
https://www.bib.irb.hr/14310
https://www.bib.irb.hr/14310
Autor:
David Finkelstein, Kenneth E. Thummel, Amarjit S. Chaudhry, Sarah C. Sim, Eleni Aklillu, Shuoguo Wang, Alison E. Fohner, Bhagwat Prasad, Yoshiyuki Shirasaka, Erin G. Schuetz, Gang Wu, Yiping Fan
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 43(8)
CYP2C19 rs12769205 alters an intron 2 branch point adenine leading to an alternative mRNA in human liver with complete inclusion of intron 2 (exon 2B). rs12769205 changes the mRNA reading frame, introduces 87 amino acids, and leads to a premature sto
Autor:
Barry H. Rumack
Publikováno v:
Journal of Toxicology: Clinical Toxicology. 40:3-20
The acetaminophen nomogram including its uses and limitations is discussed as well as the development of the N-acetylcysteine protocol. While it has taken many years to elucidate the genetic variability and true multiplicity of the cytochrome P450
Publikováno v:
Pharmacology Biochemistry and Behavior. 51:119-124
The promnesic effects of RU 35 926 (CI-979), a muscarinic receptor agonist, were evaluated on memory impairments induced by the muscarinic antagonist scopolamine, using a radial arm maze task, in comparison with tetrahydroaminoacridine (THA), a choli
Publikováno v:
Clinical Cancer Research. 22:35-35
Chemotherapy resistance is a major obstacle to curing cancer patients. Over 90% of metastatic tumors are resistant to chemotherapy, leading to treatment failure. Although glucocorticoid receptor agonists (GRAs) are a very commonly used class of compo
Publikováno v:
European Journal of Medicinal Chemistry. 31:431-438
Summary A series of Schiff bases was prepared by reaction of sulfanilamide with substituted benzene- and heterocyclic aldehydes. The compounds were characterized by standard procedures, and were assayed as inhibitors of the zinc enzyme carbonic anhyd
Publikováno v:
The Journal of antimicrobial chemotherapy. 54(6)
Objectives Fifty isolates of Burkholderia pseudomallei and 15 isolates of Burkholderia mallei were tested for their susceptibilities to 35 antimicrobial agents, including agents not previously tested against these bacteria. Methods MICs were determin