Zobrazeno 1 - 10
of 1 278
pro vyhledávání: '"35"'
Autor:
Tomoh Matsumiya, Hiroshi Tanaka, Ryo Hayakari, Tadaatsu Imaizumi, Kunikazu Tanji, Manabu Murakami, Taku Shimada, Hidemi Yoshida, Kyogo Shirai
Publikováno v:
Brain Research. 1658:60-67
Interferon (IFN)-stimulated genes (ISGs) exert multiple functions in immune system. IFN-induced protein 35 (IFI35) is a member of ISGs, and has been suggested to regulate innate immune reaction. However, the physiological functions and pathological r
Autor:
Hidemi Yoshida, Hiroshi Tanaka, Kazushi Tsuruga, Shogo Kawaguchi, Manabu Murakami, Tadaatsu Imaizumi, Chikashi Yano, Shojiro Watanabe, Tomoh Matsumiya, Koji Tsugawa, Akiko Numata, Ryo Hayakari
Publikováno v:
Kidney & Blood Pressure Research, Vol 41, Iss 5, Pp 635-642 (2016)
Activation of Toll-like receptor 3 (TLR3) signaling followed by type I interferon (IFN) expression is crucial in antiviral and "pseudoviral" immune reactions in renal mesangial cells (MCs). These reactions are probably involved in the pathogenesis of
Autor:
Carlos Eduardo Steiner, Héctor Yuri Conti Wanderley, Melanie Walter, Soraia Poloni, Johanna Kugele, Giovana Regina Weber Hoss, Hélio Fernandes da Rocha, Fernanda Sperb-Ludwig, Eugênia Ribeiro Valadares, Pricila Bernardi, Maria Juliana Rodovalho Doriqui, Chong Ae Kim, Gerson Carvalho, Ney Boa-Sorte, Carolina Araujo Moreno, Charles Marques, Lorena Gallego-Villar, Márcia Gonçalves Ribeiro, Taciane Borsatto, Carolina Fischinger Moura de Souza, Emília Katiane Embiruçu, Ida Vanessa Doederlein Schwartz, Henk J. Blom, Osvaldo Alfonso Pinto Artigalas
Publikováno v:
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Universidade de São Paulo (USP)
instacron:USP
BACKGROUND Classical homocystinuria (HCU) is a monogenic disease caused by the deficient activity of cystathionine β-synthase (CβS). The objective of this study was to identify the CBS mutations in Brazilian patients with HCU. METHODS gDNA samples
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9cb17972d8d617e56ccd1694c05b9ab9
Autor:
Christine C. Yokoyama, Nicholas N. Jarjour, Anshu P. Gounder, Adrianus C. M. Boon, Brian T. Edelson, Traci L. Bricker
Publikováno v:
PLoS Pathogens, Vol 14, Iss 4, p e1007001 (2018)
PLoS Pathogens
PLoS Pathogens
Pro-inflammatory cytokinemia is a hallmark of highly pathogenic H5N1 influenza virus (IAV) disease yet little is known about the role of host proteins in modulating a pathogenic innate immune response. The host Interferon Induced Protein 35 (Ifi35) h
Publikováno v:
The Pharmacogenomics Journal. 9:274-282
Cytochrome P450 2A6 (CYP2A6) is the primary human enzyme involved in nicotine metabolism. The objective of this study was to characterize two nonsynonymous single nucleotide polymorphisms in CYP2A6(*)24, 594GC (Val110Leu) and 6458AT (Asn438Tyr). We d
Autor:
David Finkelstein, Kenneth E. Thummel, Amarjit S. Chaudhry, Sarah C. Sim, Eleni Aklillu, Shuoguo Wang, Alison E. Fohner, Bhagwat Prasad, Yoshiyuki Shirasaka, Erin G. Schuetz, Gang Wu, Yiping Fan
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 43(8)
CYP2C19 rs12769205 alters an intron 2 branch point adenine leading to an alternative mRNA in human liver with complete inclusion of intron 2 (exon 2B). rs12769205 changes the mRNA reading frame, introduces 87 amino acids, and leads to a premature sto
Publikováno v:
Molecular Microbiology. 31:633-639
Ketolides represent a new generation of macrolide antibiotics. In order to identify the ketolide-binding site on the ribosome, a library of Escherichia coli clones, transformed with a plasmid carrying randomly mutagenized rRNA operon, was screened fo
Publikováno v:
Molecular Brain Research. 23:191-203
D1 dopamine (DA) receptor agonists induce the expression of the opioid peptide dynorphin (DYN) in the striatum, an effect accentuated several fold by removing the dopaminergic innervation to the striatum (e.g., by lesioning the DA cell bodies in the
Publikováno v:
Journal of Biological Chemistry. 269:1091-1098
We have isolated a new human cDNA, named IFP 35, whose expression is regulated by interferons (IFN). Induction of IFP 35 mRNA in HeLa cells by IFN is due, at least in part, to increased transcription. In response to IFN treatment, the expression of I
Publikováno v:
Developmental and comparative immunology. 34(8)
The interleukin 2 (IL-2) immunoregulatory cytokine produces its biological effects by binding sequentially to its cell receptor subunits, alpha (CD25), beta (CD122), and common gamma chain (CD132). In this study, we identified the critical amino acid