Zobrazeno 1 - 10
of 285
pro vyhledávání: '"35"'
Publikováno v:
Pharmacology Biochemistry and Behavior. 51:119-124
The promnesic effects of RU 35 926 (CI-979), a muscarinic receptor agonist, were evaluated on memory impairments induced by the muscarinic antagonist scopolamine, using a radial arm maze task, in comparison with tetrahydroaminoacridine (THA), a choli
Publikováno v:
Clinical Cancer Research. 22:35-35
Chemotherapy resistance is a major obstacle to curing cancer patients. Over 90% of metastatic tumors are resistant to chemotherapy, leading to treatment failure. Although glucocorticoid receptor agonists (GRAs) are a very commonly used class of compo
Publikováno v:
European Journal of Cancer Supplements. 4:15
Publikováno v:
Xenobiotica; the fate of foreign compounds in biological systems. 2(5)
1. 4-Aminomethylbenzenesulphonamide (homosulphanilamide) labelled with 35S has been synthesized.2. When the labelled drug was given orally to rats, rabbits, guinea pigs and rhesus monkeys, it was mainly deaminated to 4-carboxybenzenesulphonamide, but
Autor:
Yu.O. Tatskiy, G.V. Zaychenko
Publikováno v:
Медична наука України, Vol 17, Iss 1, Pp 68-73 (2021)
Relevance. In the experiment, it was shown that in rats with a sulpiride induced prostate hyperplasia (SGP) which was treated by the Maclura Pomifera oil extract (OEM), a prostatic index is normalized, biochemical indicators and morphofunctional stat
Publikováno v:
Clinical and Experimental Pharmacology and Physiology. 46:567-574
Although it is recognized that α1 -adrenoceptors are coupled to diverse intracellular signalling pathways, its primary transduction mechanisms are evoked by activating phospholipase C in the cell membrane through Gαq/11 , resulting in production of
Autor:
Howard Y. Park, Anthony A. Scaduto, George E. Nelson, Yan Hu, Kevin P. Francis, Stephen D. Zoller, Vishal Hegde, Christopher D. Hamad, Nicholas M. Bernthal, Amanda H. Loftin, Daniel Johansen, Erik M. Dworsky
Publikováno v:
PLoS ONE
PLoS ONE, Vol 12, Iss 2, p e0173019 (2017)
PloS one, vol 12, iss 2
PLoS ONE, Vol 12, Iss 2, p e0173019 (2017)
PloS one, vol 12, iss 2
Background Management of spine implant infections (SII) are challenging. Explantation of infected spinal hardware can destabilize the spine, but retention can lead to cord compromise and biofilm formation, complicating management. While vancomycin mo
Publikováno v:
Journal of Experimental Marine Biology and Ecology. 452:47-53
The barnacle Amphibalanus (= Balanus ) amphitrite is a typical marine fouling invertebrate, with adults releasing planktonic larvae that settle and further metamorphose into juveniles on submerged surfaces. The mechanisms regulating larval selection
5-HT6 Receptor Agonist and Antagonist Against β-Amyloid-Peptide-Induced Neurotoxicity in PC-12 Cells
Publikováno v:
Neurochemical research. 42(5)
Beta-amyloid peptide (Aβ) induced neurotoxicity is considered as a hallmark of the pathogenesis of Alzheimer’s disease (AD). The present study demonstrated the neuroprotective role of 5-HT6 receptors against Aβ-induced neurotoxicity in PC-12 cell
Autor:
Toshimasa Itoh, Tomohisa Tsuyuki, Tsutomu Suzuki, Kotaro Takeda, Masahiro Shibasaki, Kenjiro Watanabe, Minoru Narita, Tomohisa Mori
Publikováno v:
Psychopharmacology. 228:207-215
Both the acute and chronic consumption of ethanol have been reported to modify several molecular events in the central nervous system, and the endogenous μ-opioid receptor system is involved in the reinforcing/rewarding effects of ethanol.The presen