Zobrazeno 1 - 10
of 1 329
pro vyhledávání: '"Thomas H"'
Autor:
Eleonore Baughan, Koji Takeda, Maryjane Farr, Jayant Raikhelkar, Justin Fried, Hannah Rosenblum, Thomas H. Brannagan, Mathew S. Maurer, Nir Uriel, Charles C. Marboe, Kevin J. Clerkin, Justin L. Grodin, Jan M. Griffin
Publikováno v:
The Journal of Heart and Lung Transplantation. 41:199-207
Introduction Heart Transplantation (HT) is a rational therapy for advanced transthyretin cardiac amyloidosis (ATTR-CA), but the impact of ongoing amyloid deposition is not well defined. We evaluated a cohort of patients who underwent HT for ATTR-CA t
Autor:
Thomas H. Hostetter, Timothy W. Meyer
Publikováno v:
Clin J Am Soc Nephrol
The high GFR in vertebrates obligates large energy expenditure. Homer Smith’s teleologic argument that this high GFR was needed to excrete water as vertebrates evolved in dilute seas is outdated. The GFR is proportional to the metabolic rate among
Autor:
Peter B. Noël, Taylor A. Black, Despina Kontos, Stephanie S. Yee, Michael J. LaRiviere, Wei-Ting Hwang, Erica L. Carpenter, Charu Aggarwal, Austin L. Chien, Sharyn I. Katz, Eric A. Cohen, Bardia Yousefi, Jeffrey C. Thompson, Thomas H. Buckingham
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Scientific Reports
Scientific Reports
Among non-small cell lung cancer (NSCLC) patients with therapeutically targetable tumor mutations in epidermal growth factor receptor (EGFR), not all patients respond to targeted therapy. Combining circulating-tumor DNA (ctDNA), clinical variables, a
Autor:
Nyoman D. Kurniawan, Margarita Saenz, Melissa J. Davis, Anna Salerno-Kochan, Julie S. Cohen, Sebastian Glatt, Anna Kościelniak, Ali Fatemi, Mikael Bodén, Martin F. Boxill, Joy Lee, Woo Jun Shim, Nathan J. Palpant, Tomasz Gawda, Jonas K. Hansen, Katarzyna Drożdżyk, Alexander Begg, Rikke S. Møller, Michael Piper, Marija Kojic, Soroor Hediyeh-Zadeh, Thomas H. J. Burne, Brandon J. Wainwright, Kathleen Brown, Isabelle Marey, Sergey Mureev, Rannvá K. Abrahamsen, Enakshi Sinniah, Zornitza Stark, Laura A. Genovesi, Monika Gaik, Andrzej Chramiec-Głąbik, Suzanne Alexander, Alun Jones, Alina Batzilla, Christina Fenger, Camilla Gøbel Madsen, Maria Kasherman, Boris Keren, Sebastian Lunke
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
Kojic, M, Gawda, T, Gaik, M, Begg, A, Salerno-Kochan, A, Kurniawan, N D, Jones, A, Drożdżyk, K, Kościelniak, A, Chramiec-Głąbik, A, Hediyeh-Zadeh, S, Kasherman, M, Shim, W J, Sinniah, E, Genovesi, L A, Abrahamsen, R K, Fenger, C D, Madsen, C G, Cohen, J S, Fatemi, A, Stark, Z, Lunke, S, Lee, J, Hansen, J K, Boxill, M F, Keren, B, Marey, I, Saenz, M S, Brown, K, Alexander, S A, Mureev, S, Batzilla, A, Davis, M J, Piper, M, Bodén, M, Burne, T H J, Palpant, N J, Møller, R S, Glatt, S & Wainwright, B J 2021, ' Elp2 mutations perturb the epitranscriptome and lead to a complex neurodevelopmental phenotype ', Nature Communications, vol. 12, 2678 . https://doi.org/10.1038/s41467-021-22888-5
Kojic, M, Gawda, T, Gaik, M, Begg, A, Salerno-Kochan, A, Kurniawan, N D, Jones, A, Drożdżyk, K, Kościelniak, A, Chramiec-Głąbik, A, Hediyeh-Zadeh, S, Kasherman, M, Shim, W J, Sinniah, E, Genovesi, L A, Abrahamsen, R K, Fenger, C D, Madsen, C G, Cohen, J S, Fatemi, A, Stark, Z, Lunke, S, Lee, J, Hansen, J K, Boxill, M F, Keren, B, Marey, I, Saenz, M S, Brown, K, Alexander, S A, Mureev, S, Batzilla, A, Davis, M J, Piper, M, Bodén, M, Burne, T H J, Palpant, N J, Møller, R S, Glatt, S & Wainwright, B J 2021, ' Elp2 mutations perturb the epitranscriptome and lead to a complex neurodevelopmental phenotype ', Nature Communications, vol. 12, 2678 . https://doi.org/10.1038/s41467-021-22888-5
Intellectual disability (ID) and autism spectrum disorder (ASD) are the most common neurodevelopmental disorders and are characterized by substantial impairment in intellectual and adaptive functioning, with their genetic and molecular basis remainin
Autor:
Michaela Auer-Grumbach, Esther Gonzalez, Brian M. Drachman, Chiara Briani, Andrew M. Rosen, Morie A. Gertz, Angela Dispenzieri, Frederick L. Ruberg, Márcia Waddington-Cruz, Julian D. Gillmore, David R. Hurwitz, Thomas H. Brannagan, Hanna K. Gaggin, Hartmut Schmidt, Luis F. Quintana, Kemi Olugemo, Thibaud Damy, Teresa Coelho, John L. Berk, Vera Bril, Jacqueline Shehata, Mazen Hanna, Nowell M. Fine, Carol J. Whelan, Jose Nativi-Nicolau, Sami Khella, Mathew S. Maurer
Publikováno v:
Orphanet Journal of Rare Diseases, Vol 16, Iss 1, Pp 1-13 (2021)
Orphanet Journal of Rare Diseases
Orphanet Journal of Rare Diseases
BackgroundThe global spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection causing the ongoing coronavirus disease 2019 (COVID-19) pandemic has raised serious concern for patients with chronic disease. A correlation has bee
Autor:
Vilmundur Gudnason, Solomon K. Musani, Yi-Ping Fu, Albert V. Smith, Yii-Der Ida Chen, Annapurna Kuppa, Xiuqing Guo, Matthew A. Allison, Sharon L.R. Kardia, Donald W. Bowden, Gudny Eirksdottir, Jill M. Norris, Jian Yang, Bratati Kahali, Yanhua Chen, Thomas H. Mosley, Elizabeth K. Speliotes, Lenore J. Launer, James G. Terry, Brian D. Halligan, Jerome I. Rotter, Matthew J. Budoff, Kent D. Taylor, Kathleen A. Ryan, Breland F. Crudup, Adolfo Correa, Lawrence F. Bielak, Jeffrey R. O'Connell, Michael A. Province, Patricia A. Peyser, Nicholette D. Palmer, Christopher J. O'Donnell, Mary F. Feitosa, Lynne E. Wagenknecht, J. Jeffrey Carr, Xiaomeng Du
Publikováno v:
Human molecular genetics, vol 30, iss 15
Hum Mol Genet
Hum Mol Genet
Nonalcoholic fatty liver disease (NAFLD) is a leading cause of chronic liver disease and is highly correlated with metabolic disease. NAFLD results from environmental exposures acting on a susceptible polygenic background. This study performed the la
Autor:
Amanda B. Nymon, Zhongyou Li, Alix Ashare, Roxanna Barnaby, Thomas H. Hampton, Bruce A Stanton, Katja Koeppen
Publikováno v:
Am J Physiol Lung Cell Mol Physiol
Mutations in CFTR alter macrophage responses, for example, by reducing their ability to phagocytose and kill bacteria. Altered macrophage responses may facilitate bacterial infection and inflammation in the lungs, contributing to morbidity and mortal
Autor:
Steven P. Sinkins, Luke Alphey, Jolene T. Sutton, Chris N. Niebuhr, Tim Harvey-Samuel, Patricia G. Parker, Thomas H. Ant, Samoa Asigau
Publikováno v:
CABI Agriculture and Bioscience, Vol 2, Iss 1, Pp 1-21 (2021)
The avifauna endemic to islands is particularly susceptible to population declines and extinctions resulting from the introduction of non-native pathogens. Three pathogens of concern are the avian malaria parasites, the avian poxviruses, and West Nil
Publikováno v:
Journal of Human Hypertension. 36:485-487
OVERVIEW Angiotensin-converting enzyme inhibitors (ACEI) and angiotensin-receptor blockers (ARB) are the most commonly prescribed anti-hypertensive medications in the United States, yet whether ACEI or ARB use is associated with a greater risk of hyp
Autor:
Ammarina Beumer-Chuwonpad, Regina Stark, Natasja A. M. Kragten, Felix M. Behr, Thomas H. Wesselink, Klaas P. J. M. van Gisbergen
Publikováno v:
European journal of immunology, 51(1), 151-166. Wiley-VCH Verlag
Tissue-resident memory CD8+ T cells (TRM ) localize to barrier tissues and mediate local protection against reinvading pathogens. Circulating central memory (TCM ) and effector memory CD8+ T cells (TEM ) also contribute to tissue recall responses, bu