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Autor:
Kazuaki Chayama, Joselyn N. Allen, T. Jake Liang, Seung Bum Park, Tadashi Inuzuka, Takuro Uchida, Min Zhang
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 23, Iss, Pp 597-605 (2021)
Molecular Therapy. Methods & Clinical Development
Molecular Therapy. Methods & Clinical Development
The sodium-dependent taurocholate co-transporting polypeptide (NTCP)-S267F variant is known to be associated with a reduced risk of hepatitis B virus (HBV) infection and disease progression. The NTCP-S267F variant displays diminished function in medi
Autor:
Philipp Girl, Heiner von Buttlar, Stefanie Gruetzner, Andreas Giebl, Markus H. Antwerpen, Roman Wölfel, Elham Khatamzas, Katharina Müller
Publikováno v:
Virus Genes
SARS-CoV-2 infections elicit a humoral immune response capable of neutralising the virus. However, multiple variants have emerged with mutations in the spike protein amongst others, the key target of neutralising antibodies. We evaluated the neutrali
Publikováno v:
Molecular Biology Reports
BackgroundThe new SARS-CoV-2 variant VUI (202012/01), identified recently in the United Kingdom (UK), exhibits a higher transmissibility rate compared to other variants, and a reproductive number 0.4 higher. In the UK, scientists were able to identif
Publikováno v:
Archives of Microbiology
The causative agent of COVID-19 is a novel betacoronavirus or severe acute respiratory syndrome coronavirus (SARS-CoV-2), which has emerged as a pandemic of global concern. Considering its rapid transmission, WHO has declared public health emergency
Autor:
Md. Mizanur Rahaman, Nadira Naznin Rakhi, Otun Saha, Israt Islam, Rokaiya Nurani Shatadru, Md. Shahadat Hossain
Publikováno v:
Virus Genes
Along with intrinsic evolution, adaptation to selective pressure in new environments might have resulted in the circulatory SARS-CoV-2 strains in response to the geoenvironmental conditions of a country and the demographic profile of its population.
Autor:
Yongzheng Li, Jiajing Wu, Xiaoyu Xu, Ran An, Xiaoliang Sunney Xie, Rui Shi, Na-Na Zhang, Chuanping Gao, Liyang Song, Yingmin Ma, Ayijiang Yisimayi, Xuemei Li, Yali Bai, Y Cao, Youchun Wang, Tianhe Xiao, Shuo Du, Yangyang Wei, Yifei Zhang, Wenping Ma, Xiang Li, Junyu Xiao, Weiliang Song, Cheng-Feng Qin, Bin Su, Shuo Liu, Jing Wang, Zhiying Zhang, Xiaofeng Li, Tianjiao Yuan, Ronghua Jin, Yingmei Feng, Yang Dou, Yonghong Zhang, Bai Lu, Weijin Huang, Xianghua Guo
Publikováno v:
Cell Research
SARS-CoV-2 variants could induce immune escape by mutations on the receptor-binding domain (RBD) and N-terminal domain (NTD). Here we report the humoral immune response to circulating SARS-CoV-2 variants, such as 501Y.V2 (B.1.351), of the plasma and
Autor:
Akhilesh Chandra Mishra, Sanjay Lalwani, Vidya A. Arankalle, Shubham Shrivastava, Harshad P. Patil, Suhas T. Mhaske, Sonali Palkar
Publikováno v:
Virus Genes
In view of the rapidly progressing COVID-19 pandemic, our aim was to isolate and characterize SARS-CoV-2 from Indian patients. SARS-CoV-2 was isolated from nasopharyngeal swabs collected from the two members of a family without any history of (H/O) t
Publikováno v:
International Journal of Biological Macromolecules. 173:513-523
Classical swine fever is a highly contagious disease in China. Although vaccination against Classical swine fever virus (CSFV) has been widely carried out in China, CSFV cases still emerge in an endless stream. Therefore, it is necessary to take new
Publikováno v:
Journal of Biomolecular Structure and Dynamics. 40:5283-5294
Hepatitis C virus (HCV) NS3/4A serine protease is a promising drug target for the discovery of anti-HCV drugs. However, its amino acid mutations, particularly A156T, commonly lead to rapid emergence of drug resistance. Paritaprevir and glecaprevir, t
Autor:
Shrikant Sharma, Gabriele Varani
Publikováno v:
Biochem Biophys Res Commun
Flaviviruses are major emerging human pathogenic viruses that pose a persistent and growing menace to global health. They are enveloped single-stranded RNA viruses with positive polarity transmitted by arthropod vectors like mosquitoes or ticks, resp