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Publikováno v:
Antioxidants & Redox Signaling. 37:451-480
SIGNIFICANCE Currently 10-15% of couples in reproductive age face infertility issues. More importantly, male factor contributes to 50% of these cases (either alone or in combination with female causes). Amongst various reasons, impaired sperm functio
Publikováno v:
Medical Molecular Morphology. 55(2):85-90
Endometriosis is a benign tumor that affect 6-10% women of reproductive age. To date, it is suggested that the aberrant microRNA (miRNA) expressions play important roles in the pathogenesis of endometriosis. Reviewing the literature, we found nine ov
Background Isolation of neurons from the adult mouse CNS is important in order to study their gene expression during development or the course of different diseases. New methods Here we present two different methods for the enrichment or isolation of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a758d54fb5b09d0bcddad86dfaf1e28d
Publikováno v:
Laboratory Investigation. 102:320-328
An exploration of the underlying mechanisms is necessary to improve nerve myelin-forming cell Schwann cell (SC) differentiation from adipose-derived stem cells (ADSCs). Primary rat ADSCs were isolated and characterised for cell surface markers using
Autor:
Jiarui Wang, Xianqin Zhang, Tingting Zou, Dazhi Zhang, Wenqiang Liu, Zhenxing Liu, Xuejie Peng, Zhengyi Ni, Yang Tan, Meiqi Hou, Mi Zhou, Chao Yuan, Xiaopei Zhou
Publikováno v:
Biochemical and Biophysical Research Communications. 591:124-129
Mendelian susceptibility to mycobacterial disease (MSMD) is a rare monogenetic disease, which is characterized by susceptibility to some weakly virulent mycobacteria. Here, we explored the pathogenic genes and molecular mechanisms of MSMD patients. W
Publikováno v:
Developmental Biology. 482:17-27
Spermatogenesis is a dynamic process of cellular differentiation that generates the mature spermatozoa required for reproduction. Errors that arise during this process can lead to sterility due to low sperm counts and malformed or immotile sperm. Whi
Publikováno v:
IET Systems Biology, Vol 16, Iss 1, Pp 28-41 (2022)
Stroke is one of the leading causes of patients' death and long‐term disability worldwide, and ischaemic stroke (IS) accounts for nearly 80% of all strokes. Differential genes and weighted gene co‐expression network analysis (WGCNA) in male and f
Autor:
Changqing Zeng, Amir Abliz, Yaqiang Hong, Xinchang Zheng, Zhen Wu, Xiaonan Guan, Qianfei Wang, Mengfei Liu, Qingtao Hu, Aili Chen, Fuxin Zhao, Jian Bai, Shaoyan Hu, Hong Cai, Wei Chen, Junting Zhang, Xiangtian Zhou, Dake Zhang, Yang Ke, Kenan Gong, Yue Ma, Hongzhu Qu, Liang Wang, Shujuan Lai, Shuang Hao
Publikováno v:
Genomics, Proteomics & Bioinformatics. 20:177-191
Postzygotic mutations are acquired in normal tissues throughout an individual's lifetime and hold clues for identifying mutagenic factors. Here, we investigated postzygotic mutation spectra of healthy individuals using optimized ultra-deep exome sequ
Publikováno v:
Genome Medicine, Vol 14, Iss 1, Pp 1-16 (2022)
Background The mutational profile of cancer reflects the activity of the mutagenic processes which have been operative throughout the lineage of the cancer cell. These processes leave characteristic profiles of somatic mutations called mutational sig
Autor:
Edwin P. Kirk, Robert W. Taylor, Canny Sugiana, Denise M. Kirby, Avihu Boneh, Hans Henrik M. Dahl, Renato Salemi, Katrina M. Bell, Akira Ohtake, David R. Thorburn, Michael T. Ryan, Lee Parry
Complex I deficiency, the most common respiratory chain defect, is genetically heterogeneous: mutations in 8 nuclear and 7 mitochondrial DNA genes encoding complex I subunits have been described. However, these genes account for disease in only a min
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d509e64439ba9680fdc699a1acc871a