Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Hansell A"'
Autor:
Michelle L Le Brocq, John Dm Campbell, Gerard J. Graham, Rachel S Cooper, Christopher A.H. Hansell, Paul Burgoyne, Alan J. Hayes
Publikováno v:
Journal of Leukocyte Biology. 111:1243-1251
Dendritic cell therapy has been a promising addition to the current armory of therapeutic options in cancer for more than 20 years but has not yet achieved breakthrough success. To successfully initiate immunity, dendritic cells have to enter the lym
Autor:
Gerard J. Graham, Megan K. L. MacLeod, Gillian J. Wilson, Samantha Love, Christopher A.H. Hansell, Marieke Pingen
Publikováno v:
European Journal of Immunology
Analysis of chemokine receptor, and atypical chemokine receptor, expression is frequently hampered by the lack of availability of high‐quality antibodies and the species specificity of those that are available. We have previously described methodol
Autor:
J Cole, Mkl MacLeod, G Finney, Julie C. Worrell, J Singh Nijjar, F. Morton, Christopher A.H. Hansell
Publikováno v:
Understanding lung infection: back to basics.
Introduction and Objectives Influenza A virus (IAV) causes respiratory infections that are a significant cause of morbidity and mortality worldwide. Stromal cells serve an important function in innate immune responses by co ordinating with immune cel
Autor:
Stefan Enroth, Robert J. Hall, James D. Crapo, Frederick E. Dewey, Victoria E. Jackson, Eleftheria Zeggini, Gudmar Thorleifsson, Terho Lehtimäki, David J. Porteous, Nicole Probst-Hensch, Ian J. Deary, A. Mesut Erzurumluoglu, Bram P. Prins, Maarten van den Berge, Craig E. Pennell, Catherine John, Terri H. Beaty, Claudia Schurmann, Michael H. Cho, Veronique Vitart, Erwin P. Bottinger, Carol A. Wang, H. Lester Kirchner, Medea Imboden, David J. Carey, Archie Campbell, Kari Stefansson, Matthias Wielscher, Ida Surakka, Igor Rudan, Shona M. Kerr, Holger Schulz, Michael A. Portelli, Thorarinn Gislason, Peter D. Paré, James F. Wilson, Boris Noyvert, Beate Stubbe, Zhengming Chen, Ruth J. F. Loos, Ma'en Obeidat, María Soler Artigas, Philippe Joubert, Kathleen C. Barnes, Christian Gieger, Andrew P. Morris, Rajesh Rawal, Yohan Bossé, Peter K. Joshi, Nadia N. Hansel, Emily S. Wan, David M. Evans, David C. Nickle, Caroline Hayward, Stefan Karrasch, Ke Hao, Tracy L. Rimington, Don D. Sin, Alan James, Stefan Jonsson, Shannon Bruse, Amanda P. Henry, Iona Y Millwood, Lara Bossini-Castillo, Ian P. Hall, David Sparrow, Ulf Gyllensten, Ian Sayers, Edwin K. Silverman, Robert Busch, David P. Strachan, Martin D. Tobin, Nick Shrine, Louise V. Wain, Robin G. Walters, Ingileif Jonsdottir, Peter D. Sly, Liming Li, Charlotte K. Billington, Anna Hansell, Omri Gottesman, Om P Kurmi, Ingo Ruczinski, Nicholas J. Wareham, Amund Gulsvik, Per Bakke, Jennie Hui, Corry-Anke Brandsma, Gosia Trynka, Anthony G. Fenech, Brian D. Hobbs, A. John Henderson, Jonathan Marten, Olli T. Raitakari, Richard J. Allen, Augusto A. Litonjua, Sarah E. Harris, Ozren Polasek, Mika Kähönen, Tineka Blake, Marjo-Riitta Järvelin, Rasika A. Mathias, Jing Hua Zhao, Julien Vaucher, Girish N. Nadkarni, Christopher E. Brightling
Publikováno v:
Nature Genetics, 49(3), 416-425. Nature Publishing Group
Nat. Genet. 49, 416-425 (2017)
Nature genetics
Wain, L V, Shrine, N, Artigas, M S, Erzurumluoglu, A M, Noyvert, B, Bossini-Castillo, L, Obeidat, ME, Henry, A P, Portelli, M A, Hall, R J, Billington, C K, Rimington, T L, Fenech, A G, John, C, Blake, T, Jackson, V E, Allen, R J, Prins, B P, Campbell, A, Porteous, D J, Jarvelin, M R, Wielscher, M, James, A L, Hui, J, Wareham, N J, Zhao, J H, Wilson, J F, Joshi, P K, Stubbe, B, Rawal, R, Schulz, H, Imboden, M, Probst-Hensch, N M, Karrasch, S, Gieger, C, Deary, I J, Harris, S E, Marten, J, Rudan, I, Enroth, S, Gyllensten, U, Kerr, S M, Polasek, O, Kähönen, M, Surakka, I, Vitart, V, Hayward, C, Lehtimäki, T, Raitakari, O T, Evans, D M, Henderson, A J, Pennell, C E, Wang, C A, Sly, P D, Wan, E S, Busch, R, Hobbs, B D, Litonjua, A A, Sparrow, D W, Gulsvik, A, Bakke, P S, Crapo, J D, Beaty, T H, Hansel, N N, Mathias, R A, Ruczinski, I, Barnes, K C, Bossé, Y, Joubert, P, Van Den Berge, M, Brandsma, C A, Paré, P D, Sin, D D, Nickle, D C, Hao, K, Gottesman, O, Dewey, F E, Bruse, S E, Carey, D J, Kirchner, H L, Jonsson, S, Thorleifsson, G, Jonsdottir, I, Gislason, T, Stefansson, K, Schurmann, C, Nadkarni, G, Bottinger, E P, Loos, R J F, Walters, R G, Chen, Z, Millwood, I Y, Vaucher, J, Kurmi, O P, Li, L, Hansell, A L, Brightling, C, Zeggini, E, Cho, M H, Silverman, E K, Sayers, I, Trynka, G, Morris, A P, Strachan, D P, Hall, I P & Tobin, M 2017, ' Genome-wide association analyses for lung function and chronic obstructive pulmonary disease identify new loci and potential druggable targets ', Nature Genetics, vol. 49, no. 3, pp. 416-425 . https://doi.org/10.1038/ng.3787
Wain, L V, Shrine, N, Artigas, M S, Erzurumluoglu, A M, Noyvert, B, Bossini-Castillo, L, Obeidat, M, Henry, A P, Portelli, M A, Hall, R J, Billington, C K, Rimington, T L, Fenech, A G, John, C, Blake, T, Jackson, V E, Allen, R J, Prins, B P, Campbell, A, Porteous, D J, Jarvelin, M-R, Wielscher, M, James, A L, Hui, J, Wareham, N J, Zhao, J H, Wilson, J F, Joshi, P K, Stubbe, B, Rawal, R, Schulz, H, Imboden, M, Probst-Hensch, N M, Karrasch, S, Gieger, C, Deary, I J, Harris, S E, Marten, J, Rudan, I, Enroth, S, Gyllensten, U, Kerr, S M, Polasek, O, Kähönen, M, Surakka, I, Vitart, V, Hayward, C, Lehtimäki, T & Raitakari, O T & Morris, A P 2017, ' Genome-wide association analyses for lung function and chronic obstructive pulmonary disease identify new loci and potential druggable targets ', Nature Genetics, vol. 49, no. 3, pp. 416-425 . https://doi.org/10.1038/ng.3787
Nature Genetics
Nat. Genet. 49, 416-425 (2017)
Nature genetics
Wain, L V, Shrine, N, Artigas, M S, Erzurumluoglu, A M, Noyvert, B, Bossini-Castillo, L, Obeidat, ME, Henry, A P, Portelli, M A, Hall, R J, Billington, C K, Rimington, T L, Fenech, A G, John, C, Blake, T, Jackson, V E, Allen, R J, Prins, B P, Campbell, A, Porteous, D J, Jarvelin, M R, Wielscher, M, James, A L, Hui, J, Wareham, N J, Zhao, J H, Wilson, J F, Joshi, P K, Stubbe, B, Rawal, R, Schulz, H, Imboden, M, Probst-Hensch, N M, Karrasch, S, Gieger, C, Deary, I J, Harris, S E, Marten, J, Rudan, I, Enroth, S, Gyllensten, U, Kerr, S M, Polasek, O, Kähönen, M, Surakka, I, Vitart, V, Hayward, C, Lehtimäki, T, Raitakari, O T, Evans, D M, Henderson, A J, Pennell, C E, Wang, C A, Sly, P D, Wan, E S, Busch, R, Hobbs, B D, Litonjua, A A, Sparrow, D W, Gulsvik, A, Bakke, P S, Crapo, J D, Beaty, T H, Hansel, N N, Mathias, R A, Ruczinski, I, Barnes, K C, Bossé, Y, Joubert, P, Van Den Berge, M, Brandsma, C A, Paré, P D, Sin, D D, Nickle, D C, Hao, K, Gottesman, O, Dewey, F E, Bruse, S E, Carey, D J, Kirchner, H L, Jonsson, S, Thorleifsson, G, Jonsdottir, I, Gislason, T, Stefansson, K, Schurmann, C, Nadkarni, G, Bottinger, E P, Loos, R J F, Walters, R G, Chen, Z, Millwood, I Y, Vaucher, J, Kurmi, O P, Li, L, Hansell, A L, Brightling, C, Zeggini, E, Cho, M H, Silverman, E K, Sayers, I, Trynka, G, Morris, A P, Strachan, D P, Hall, I P & Tobin, M 2017, ' Genome-wide association analyses for lung function and chronic obstructive pulmonary disease identify new loci and potential druggable targets ', Nature Genetics, vol. 49, no. 3, pp. 416-425 . https://doi.org/10.1038/ng.3787
Wain, L V, Shrine, N, Artigas, M S, Erzurumluoglu, A M, Noyvert, B, Bossini-Castillo, L, Obeidat, M, Henry, A P, Portelli, M A, Hall, R J, Billington, C K, Rimington, T L, Fenech, A G, John, C, Blake, T, Jackson, V E, Allen, R J, Prins, B P, Campbell, A, Porteous, D J, Jarvelin, M-R, Wielscher, M, James, A L, Hui, J, Wareham, N J, Zhao, J H, Wilson, J F, Joshi, P K, Stubbe, B, Rawal, R, Schulz, H, Imboden, M, Probst-Hensch, N M, Karrasch, S, Gieger, C, Deary, I J, Harris, S E, Marten, J, Rudan, I, Enroth, S, Gyllensten, U, Kerr, S M, Polasek, O, Kähönen, M, Surakka, I, Vitart, V, Hayward, C, Lehtimäki, T & Raitakari, O T & Morris, A P 2017, ' Genome-wide association analyses for lung function and chronic obstructive pulmonary disease identify new loci and potential druggable targets ', Nature Genetics, vol. 49, no. 3, pp. 416-425 . https://doi.org/10.1038/ng.3787
Nature Genetics
Chronic obstructive pulmonary disease (COPD) is characterized by reduced lung function and is the third leading cause of death globally. Through genome-wide association discovery in 48,943 individuals, selected from extremes of the lung function dist
Autor:
Laura Medina-Ruiz, Marieke Pingen, Ayumi Fukuoka, Gerard J. Graham, Robin Bartolini, Kit Ming Lee, Gillian J. Wilson, Christopher A.H. Hansell
Publikováno v:
PLoS Biology, Vol 17, Iss 5, p e3000287 (2019)
PLoS Biology
PLoS Biology
Atypical chemokine receptor 2 (ACKR2) is a chemokine-scavenging receptor. ACKR2–/–embryos display a reduction in size of a novel, to our knowledge, embryonic skin macrophage population referred to as ‘intermediate’ cells. CC chemokine recepto
Autor:
Robert J. B. Nibbs, Alan J. Hayes, Demi Brownlie, Megan K. L. MacLeod, Paul Burgoyne, Claire L. Burt, Laura Medina-Ruiz, Gillian J. Wilson, Alasdair R. Fraser, Gerard J. Graham, Marieke Pingen, Kit Ming Lee, Christopher A.H. Hansell
Publikováno v:
The Journal of Immunology Author Choice
Chemokines have been shown to be essential players in a range of cancer contexts. In this study, we demonstrate that mice deficient in the atypical chemokine receptor Ackr2 display impaired development of metastasis in vivo in both cell line and spon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba2b0fc6e00aba8dd2452c4a4fa576f7
https://eprints.gla.ac.uk/167348/1/167348.pdf
https://eprints.gla.ac.uk/167348/1/167348.pdf
Autor:
David M. Hansell, Michael R. Loebinger, Peter Kelleher, Joseph Jacob, Steven Cowman, Robert Wilson, William O.C.M. Cookson, Miriam F. Moffatt
The factors predisposing toward the development of pulmonary nontuberculous mycobacterial (pNTM) disease and influencing disease progression remain unclear. Impaired immune responses have been reported in individuals with pNTM disease, but data are l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bdd2eb384031e8b3e7c8dfe47568d5a5
https://europepmc.org/articles/PMC5894497/
https://europepmc.org/articles/PMC5894497/
Autor:
Laura Gutierrez, Clive S. McKimmie, Gerard J. Graham, Giovanna Lombardi, Alasdair R. Fraser, Paz Carreno, Robert J. B. Nibbs, Iain B. McInnes, Chris A. H. Hansell, Laura Connell, Sjaak Philipsen, Christina Halsey, Monika Pruenster, Antal Rot, Foo Y. Liew, Chung-Ching Chu, Mariola Kurowska-Stolarska
Publikováno v:
The Journal of Immunology. 181:8170-8181
D6 scavenges inflammatory chemokines and is essential for the regulation of inflammatory and immune responses. Mechanisms explaining the cellular basis for D6 function have been based on D6 expression by lymphatic endothelial cells. In this study, we
Autor:
Heather Brooks, Chris Hansell, Sam Withanage, Xing Wu Zhu, Duncan J. Maskell, Mark Sheppard, Ian McConnell
Publikováno v:
The Journal of Immunology. 179:5117-5125
The central importance of dendritic cells (DC) in both innate and acquired immunity is well recognized in the mammalian immune system. By contrast DC have yet to be characterized in avian species despite the fact that avian species such as the chicke
Autor:
Chris A. H. Hansell, Pek Joo Teoh, Fiona M. Menzies, Robert J. B. Nibbs, Graham J. Burton, Carolann Waddell, Scott M. Nelson, Mairi Clarke
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 193(10)
Inflammatory chemokines produced in the placenta can direct the migration of placental leukocytes using chemokine receptors that decorate the surface of these cells. Fetal trophoblasts can also express receptors for inflammatory chemokines, and they