Zobrazeno 1 - 10
of 12 586
pro vyhledávání: ''
Background Isolation of neurons from the adult mouse CNS is important in order to study their gene expression during development or the course of different diseases. New methods Here we present two different methods for the enrichment or isolation of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a758d54fb5b09d0bcddad86dfaf1e28d
Autor:
Franco Mascagni, Alexander J. McDonald
Publikováno v:
J Comp Neurol
Cortical pyramidal neurons (PNs) containing non-phosphorylated neurofilaments (NNFs) localized with the SMI-32 monoclonal antibody have been shown to be especially vulnerable to degeneration in Alzheimer's disease (AD). The present investigation is t
Autor:
James C. Sullivan, Kris De Boeck, Paul A. Negulescu, Anne Munck, Meredith C. Fidler, Mark Higgins, Fredrick Van Goor, Sylvia F. Boj, Matteo Moretto Zita, Alexandra Buckley, Robert G.J. Vries, Marvin Statia
Publikováno v:
Clinical and Translational Science, Vol 14, Iss 2, Pp 656-663 (2021)
Clinical and Translational Science
Clinical and Translational Science
In previous work, participants with a G970R mutation in cystic fibrosis transmembrane conductance regulator (CFTR) (c.2908G>C) had numerically lower sweat chloride responses during ivacaftor treatment than participants with other CFTR gating mutation
Autor:
Charlotte Mezö, Thorsten Buch, Daniel Erny, Roman Sankowski, Olaf Utermöhlen, Andrew J. Macpherson, Anna Lena Hrabě de Angelis, Jasmin Ahmari, Mercedes Gomez de Agüero, Thomas Blank, Vidmante Fuchs
Publikováno v:
Sankowski, Roman; Ahmari, Jasmin; Mezö, Charlotte; Hrabě de Angelis, Anna Lena; Fuchs, Vidmante; Utermöhlen, Olaf; Buch, Thorsten; Blank, Thomas; Gomez de Agüero, Mercedes; Macpherson, Andrew J; Erny, Daniel (2021). Commensal microbiota divergently affect myeloid subsets in the mammalian central nervous system during homeostasis and disease. The EMBO journal, 40(23), e108605. EMBO Press 10.15252/embj.2021108605
The EMBO Journal
The EMBO Journal
The immune cells of the central nervous system (CNS) comprise parenchymal microglia and at the CNS border regions meningeal, perivascular, and choroid plexus macrophages (collectively called CNS‐associated macrophages, CAMs). While previous work ha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16185d03d07b7eef41e249740526cc97
https://doi.org/10.5167/uzh-207236
https://doi.org/10.5167/uzh-207236
Autor:
Neil Pendleton, Xenia Sawkulycz, Antony Payton, Steven Bradburn, Chris Murgatroyd, Andrew C Robinson
Publikováno v:
Sawkulycz, X, Bradburn, S, Robinson, A, Payton, A, Pendleton, N & Murgatroyd, C 2020, ' Regulation of Interleukin 6 by a polymorphic CpG within the frontal cortex in Alzheimer’s disease ', Neurobiology of Aging . https://doi.org/10.1016/j.neurobiolaging.2020.04.008
The cytokine interleukin 6 (IL-6), has been linked to the pathogenesis of Alzheimer’s disease (AD). This is the first study to investigate the genetic and epigenetic interactions in the control of IL-6 in human brain and its relation to AD neuropat
Autor:
Abhirup Sarkar, Hao Wu, Eric L. Goldwaser, Mary C. Kosciuk, George A. Godsey, Robert G. Nagele, Nimish K. Acharya, Cassandra DeMarshall
Publikováno v:
Journal of Alzheimer's Disease
Blood-brain barrier (BBB) permeability is a recognized early feature of Alzheimer's disease (AD). In the present study, we examined consequences of increased BBB permeability on the development of AD-related pathology by tracking selected leaked plas
Autor:
Qing-Jie Xia, Qiao Hu, Jia Liu, Ya Jiang, You-Cui Wang, Zheng Ma, Lu-Lu Xue, Ying Zhang, Liu-Lin Xiong, Yuan Jin, Yang-Yang Wang, Ting-Hua Wang
Publikováno v:
Brain Research. 1719:77-88
Neonatal hypoxic-ischemic encephalopathy (HIE) always results in severe neurologic dysfunction, nevertheless effective treatments are limited and the underlying mechanism also remains unclear. In this study, we firstly established the neonatal HIE mo
Autor:
Nayna Sanathara, Olivier Civelli, Lamees Alhassen, Alice Lo, Wedad Alhassen, Paul Nguyen, Amal Alachkar, Alvin Phan, Hanan Shaharuddin
Publikováno v:
Brain Research. 1719:71-76
Melanin concentrating hormone (MCH) is involved in the initiation of maternal behavior during the postpartum period. Virgin females also display some aspects of maternal care independent of the hormonal and neurochemical changes associated with pregn
Autor:
Paola Lenzi, Rosangela Ferese, Francesca Biagioni, Michele Madonna, Fiona Limanaqi, Francesco Fornai, Stefano Gambardella
Publikováno v:
Brain Research. 1719:157-175
Methamphetamine (Meth) produces a variety of epigenetic effects in the brain, which are seminal to establish long-lasting alterations in neuronal activity. However, most epigenetic changes were described by measuring the rough amount of either histon
Autor:
Yan Ma, Guangwen Li, Yumin Luo, Liqun Jiao, Haiping Zhao, Ziping Han, Bingxin Yu, Qingfeng Ma, Lingzhi Li
Publikováno v:
Brain Research. 1719:104-112
Moyamoya disease (MMD) is a rare cerebrovascular disorder with higher incidences in Eastern Asian countries but the natural course remains uncertain. Circular RNAs (circRNAs) have been implicated in brain disorders, but their role in the development