Zobrazeno 1 - 10
of 2 146
pro vyhledávání: '"11"'
Publikováno v:
Molecular Medicine Reports
The present study aimed to investigate the potential effects of growth differentiation factor 11 (GDF11) on isoproterenol (ISO)‑induced heart failure (HF) and identify the underlying molecular mechanisms. A rat model of HF was induced in vivo by in
Autor:
Lu Liu, Qiuhong Qian, Baoxia Cui, Youzhong Zhang, Hongli Liu, Sai Han, Xuewu You, Xuejiao Shi, Ying Wang, Yu Sun, Yana Ma
Publikováno v:
Cancer Management and Research. 11:8081-8093
Background It is unclear whether low density lipoprotein receptor-related protein 11 (LRP11), a newly found lipoprotein receptor regulatory protein, has the carcinogenic effects in cervical cancer. Methods Bioinformatics analysis, immunohistochemical
Publikováno v:
International Journal of Hematology-Oncology and Stem Cell Research
International Journal of Hematology-Oncology and Stem Cell Research, Vol 14, Iss 1 (2020)
International Journal of Hematology-Oncology and Stem Cell Research, Vol 14, Iss 1 (2020)
Background: Aberrant methylation and histone deacetylation of tumor suppressor genes (TSGs) are the most epigenetic alterations involving in tumorigenesis. Overexpression of DNA methyltransferases (DNMTs) and histone deacetylase 1 (HDAC1) have been r
Autor:
Li Huang, Lunwen Wang
Publikováno v:
Bioscience Reports
Vascular endothelial growth factor (VEGF) plays a critical role in ovarian folliculogenesis and normal reproductive function. So far, several studies focusing on association between VEGF gene polymorphisms and polycystic ovary syndrome (PCOS). Howeve
The long non-coding (lnc)RNA cancer susceptibility 11 (CASC11) promotes gastric cancer, however its role in other diseases is unknown. The present study demonstrated upregulation of lncRNA CASC11 and microRNA (miR)-21 in hepatocellular carcinoma (HCC
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7318b2cd4bbc0497ee773897b8b443a
https://europepmc.org/articles/PMC7039114/
https://europepmc.org/articles/PMC7039114/
Autor:
Andrew Poklepovic, Cindy Sander, John M. Kirkwood, John F. Hancock, Paul Dent, Alshad S. Lalani, Laurence Booth, Jane L. Roberts
There is no efficacious standard of care therapy for uveal melanoma. Unlike cutaneous disease, uveal melanoma does not exhibit RAS mutations but instead contains mutations with ~90% penetrance in either Gα(q) or Gα(11). Previously we demonstrated t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::465d732da86bd5b8a63b566c13d066dd
https://europepmc.org/articles/PMC6606002/
https://europepmc.org/articles/PMC6606002/
Autor:
Francis J. Hornicek, Zhenfeng Duan, Jacson Shen, Xianzhe Liu, Henry J. Mankin, Edwin Choy, Yan Gao, Wen Yang
Publikováno v:
Molecular Cancer Therapeutics. 15:1691-1701
Ovarian cancer is currently the most lethal gynecologic malignancy with limited treatment options. Improved targeted therapies are needed to combat ovarian cancer. Here, we report the identification of cyclin-dependent kinase 11 (CDK11) as a mediator
Autor:
Yves Pommier, Jane B. Trepel, Vinodh N. Rajapakse, Sai-Wen Tang, Susan E. Bates, Anish Thomas, Junko Murai
Purpose: Schlafen 11 (SLFN11), a putative DNA/RNA helicase is a dominant genomic determinant of response to DNA-damaging agents and is frequently not expressed in cancer cells. Whether histone deacetylase (HDAC) inhibitors can be used to release SLFN
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::904d6a032a08c2a9acae31d241b8484d
https://europepmc.org/articles/PMC5899656/
https://europepmc.org/articles/PMC5899656/
Publikováno v:
Cancer Informatics, Vol 16 (2017)
Cancer Informatics
Cancer Informatics
Cellular glycosylation processes are vital to cell functioning. In malignant cells, they are profoundly altered. We used time-course gene expression data from the NCI-60 cancer cell lines treated with 11 antitumor agents to analyze expression changes
Autor:
Kaoru Tamura, Reina Tamura, Takahiro Ogishima, Taketoshi Maehara, Kenji Ishii, Shihori Hayashi, Tadashi Nariai, Motoki Inaji, Daisuke Kobayashi
Publikováno v:
Brain tumor pathology. 34(1)
Recent studies on gliomas have shown frequent alterations in the alpha-thalassemia/mental retardation syndrome X-linked gene (ATRX). This study was designed to determine whether ATRX status correlates with uptake of 11C-methionine in WHO grades II an