Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Weihong Song"'
Autor:
Meng Chen, Weihong Song, Zhongding Li, Dirk Schlüter, Jing Ruan, Gloria M. Manjengwa, Xu Wang, Baohua Liu
Publikováno v:
Molecular Psychiatry. 27:259-268
Neurodegenerative diseases (NDs) are characterized by the aggregation of neurotoxic proteins in the central nervous system. Aberrant protein accumulation in NDs is largely caused by the dysfunction of the two principal protein catabolism pathways, th
Autor:
Wei-Wei Li, Jin-Tai Yu, Li-Yong Chen, Wei Xu, Wang-Sheng Jin, Chi Zhu, Yang Xiang, Xiaowei Chen, Zhiming Zhu, Zhian Hu, Xian-Le Bu, Hua-Dong Zhou, Jun Wang, Zhen Wang, Ding-Yuan Tian, Gui-Hua Zeng, Bin-Lu Sun, Yan-Jiang Wang, Yu-Hui Liu, Lin-Lin Shen, Weihong Song
Publikováno v:
Translational Psychiatry, Vol 10, Iss 1, Pp 1-12 (2020)
Translational Psychiatry
Translational Psychiatry
Alzheimer’s disease (AD) is the most common cause of age-related dementia and is currently incurable. The failures of current clinical trials and the establishment of modifiable risk factors have shifted the AD intervention from treatment to preven
Publikováno v:
Neurochemical Research. 45:2113-2127
The abnormally accumulated amyloid-β (Aβ) and oxidative stress contribute to the initiation and progression of Alzheimer's disease (AD). β-site amyloid precursor protein cleaving enzyme 1 (BACE1) is the rate-limiting enzyme for the production of A
Autor:
Juelu Wang, Mingjing Liu, Daochao Huang, Xing Nie, Weihong Song, Dandan Lou, Yu Kang, Yanhua Li, Shipeng Guo, Isabel Bestard Lorigados, Weihui Zhou, Shou Yang
Publikováno v:
Molecular Brain, Vol 12, Iss 1, Pp 1-12 (2019)
Molecular Brain
Molecular Brain
Ubiquitin Specific Peptidase 16 (USP16) has been reported to contribute to somatic stem-cell defects in Down syndrome. However, how this gene being regulated is largely unknown. To study the mechanism underlyingUSP16gene expression,USP16gene promoter
Autor:
Lu Shen, Tahereh Bozorgmehr, Daochao Huang, Jifeng Guo, Yili Wu, Catharine H. Rankin, Si Zhang, Beisha Tang, Zhe Wang, Fang Cai, Weihong Song, Shuting Zhang
Publikováno v:
Molecular Psychiatry. 25:603-613
Presenilin-1 (PSEN1) is the catalytic subunit of the γ-secretase complex, and pathogenic mutations in the PSEN1 gene account for the majority cases of familial AD (FAD). FAD-associated mutant PSEN1 proteins have been shown to affect APP processing a
Autor:
Hua-Dong Zhou, Yu-Hui Liu, Weihong Song, Jun Wang, Zhi-Qiang Xu, Fan Zeng, Jin-Tai Yu, Peng Lei, Yan-Jiang Wang, Noralyn B. Mañucat-Tan, Xiu-Qing Yao, Xian-Le Bu, Wei-Wei Li, Xin-Fu Zhou, Chi Zhu, Changyue Yue Gao, Larisa Bobrovskaya, Shi-Hao Gao, Lin-Lin Shen
Publikováno v:
Molecular Psychiatry. 23:1813-1824
Tau pathology is characterized as a form of frontotemporal lobar degeneration (FTLD) known as FTLD-tau. The underlying pathogenic mechanisms are not known and no therapeutic interventions are currently available. Here, we report that the neurotrophin
Autor:
Zhilin Huang, Zhian Hu, Wang-Sheng Jin, Jia-Xiang Xiong, Weihong Song, Wei-Wei Zhang, Yan-Jiang Wang, Xin-Fu Zhou, Ya-Ni He, Zhifang Dong, Chang-Yue Gao, Lin-Lin Shen, Si-Han Chen, Yi-Zheng Wang, Xian-Le Bu, Hua-Dong Zhou
Publikováno v:
Acta Neuropathologica. 134:207-220
Clearance of amyloid-beta (Aβ) from the brain is an important therapeutic strategy for Alzheimer’s disease (AD). Current studies mainly focus on the central approach of Aβ clearance by introducing therapeutic agents into the brain. In a previous
Publikováno v:
Molecular Neurobiology. 55:1862-1870
Recent studies suggest that TMP21 is a selective modulator of γ-secretase and its dysregulation affects APP processing, leading to increased Aβ generation. However, the genetic association between Tmp21 and Alzheimer's disease (AD) remains elusive.
Autor:
Liyan Huang, Chen Zhang, Pin Wang, Yun Zhang, Yan Yun, Weihong Song, Xiulian Sun, Shichuan Tan, Carles Vilariño-Güell
Publikováno v:
Molecular psychiatry. 26(4)
Posttranscriptional regulation of gene expression plays an important role in the maturation, transport, stability and translation of coding and noncoding RNAs. RNA-binding protein (RBP) is a key factor of the regulation. Regulator of calcineurin 1 (R
Publikováno v:
Molecular Brain, Vol 12, Iss 1, Pp 1-10 (2019)
Molecular Brain
Molecular Brain
TMP21, a type I transmembrane protein of thep24 protein family, mediates protein trafficking and maturation. Dysregulation of TMP21 is implicated in the pathogenesis of Alzheimer’s disease (AD). However, underlying mechanisms remain elusive. To rev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::659caddf450795048ccf6b06a95811e2