Zobrazeno 1 - 10
of 491
pro vyhledávání: '"11"'
Publikováno v:
International journal of oncology. 41(2)
Endometrial carcinoma is the most common gynaecological malignancy. There is however a lack of curative therapies, especially for patients diagnosed with late stage, recurrent or aggressive disease, who have a poor prognosis. Interleukin (IL) 11 is a
Publikováno v:
Cancer Research. 71:P2-03
Our laboratory studied the gene expression profiles of a series of T47D variant cell lines with differential insulin receptor substrate (IRS) adaptor protein expression to develop predictive IGF-I pathway biomarkers. We identified an IGF-I-induced ge
Autor:
Tesei, Anna1 anna.tesei@irst.emr.it, Leonetti, Carlo2 leonetti@ifo.it, Di Donato, Marzia3, Gabucci, Elisa1, Porru, Manuela2, Varchi, Greta4, Guerrini, Andrea4, Amadori, Dino5, Arienti, Chiara1, Pignatta, Sara1, Paganelli, Giulia1, Caraglia, Michele6, Castoria, Gabriella3, Zoli, Wainer1
Publikováno v:
PLoS ONE. May2013, Vol. 8 Issue 5, p1-12. 12p.
Publikováno v:
Oncotarget
// Yang Sun 1 , Xinyu Li 1 , Shasha Song 1 , Yongfang Wang 1 , Heng Gu 1 1 Institute of Dermatology, Chinese Academy of Medical Science and Peking Union Medical College, Nanjing, China Correspondence to: Xinyu Li, email: xinyusli609@163.com Heng Gu,
Autor:
Cheng Zheng, Haixing Ju, Zewei Zhang, Haitao Chen, Lulu Huang, Qinghua Yao, Xiafang Zhang, Yan Wang, Chao Xu
Publikováno v:
Oncology Research
The tripartite motif-containing protein 11 (TRIM11), a member of the TRIM protein family, has attracted much attention because of its involvement in the development of the central nervous system. It has gained renewed focus because of its newly found
Autor:
Ji Shin Lee, Yogin Patel, David Reisman, Nirav Shah, Hexin Chen, Peisheng Xu, Rachel Botbyl, Shou Liu, Chunfa Jie, Eleni Markoutsa
Publikováno v:
Oncotarget
Human epidermal growth factor receptor 2 (HER2 or ErBb2) is a receptor tyrosine kinase overexpressed in 20-30% of breast cancers and associated with poor prognosis and outcome. Dysregulation of several microRNAs (miRNAs) plays a key role in breast ca
Autor:
Fabienne Berger, Katia Monastyrskaya, Ulrich Baumgartner, Ali Hashemi Gheinani, Sabrina Sofia Burgener, Erik Vassella
Publikováno v:
Molecular Cancer
Baumgartner, Ulrich; Berger, Fabienne; Hashemi Gheinani, Ali; Burgener, Sabrina Sofia; Monastyrskaya-Stäuber, Katia; Vassella, Erik (2018). miR-19b enhances proliferation and apoptosis resistance via the EGFR signaling pathway by targeting PP2A and BIM in non-small cell lung cancer. Molecular cancer, 17(1), p. 44. BioMed Central 10.1186/s12943-018-0781-5
Molecular Cancer, Vol 17, Iss 1, Pp 1-15 (2018)
Baumgartner, Ulrich; Berger, Fabienne; Hashemi Gheinani, Ali; Burgener, Sabrina Sofia; Monastyrskaya-Stäuber, Katia; Vassella, Erik (2018). miR-19b enhances proliferation and apoptosis resistance via the EGFR signaling pathway by targeting PP2A and BIM in non-small cell lung cancer. Molecular cancer, 17(1), p. 44. BioMed Central 10.1186/s12943-018-0781-5
Molecular Cancer, Vol 17, Iss 1, Pp 1-15 (2018)
Background Epidermal growth factor receptor (EGFR) mutations enable constitutive active downstream signaling of PI3K/AKT, KRAS/ERK and JAK/STAT pathways, and promote tumor progression by inducing uncontrolled proliferation, evasion of apoptosis and m
Autor:
Stephanie Everingham, Namit Sharma, Zhong Yin Zhang, Reuben Kapur, Andrew W.B. Craig, Li-Fan Zeng
Publikováno v:
Oncotarget
Acquired mutations in KIT are driver mutations in systemic mastocytosis (SM). Here, we tested the role of SHP2/PTPN11 phosphatase in oncogenic KIT signaling using an aggressive SM mouse model. Stable knock-down (KD) of SHP2 led to impaired growth, co
Autor:
Wen Mei Yu, Olgun Guvench, Mignon L. Loh, Li Da Tang, Wei Liu, Cheng-Kui Qu, Alexander D. MacKerell, Bing Yu, Shawn P. Alter
Publikováno v:
Molecular Cancer Therapeutics. 12:1738-1748
Activating mutations in PTPN11 (encoding SHP2), a protein tyrosine phosphatase (PTP) that plays an overall positive role in growth factor and cytokine signaling, are directly associated with the pathogenesis of Noonan syndrome and childhood leukemias
Autor:
Hyun-Jin Nam, Seock-Ah Im, Young-Kwang Yoon, Tae-You Kim, Sae-Won Han, Hwang-Phill Kim, Paul Elvin, Yung-Jue Bang, Ahrum Min, Do-Youn Oh, Sang-Hyun Song
Publikováno v:
Molecular Cancer Therapeutics. 12:16-26
Src is a nonreceptor tyrosine kinase involved in the cross-talk and mediation of many signaling pathways that promote cell proliferation, adhesion, invasion, migration, and tumorigenesis. Increased Src activity has been reported in many types of huma