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Autor:
Lauren Schaff, Christian Grommes
Publikováno v:
Blood. 140:971-979
Primary central nervous system lymphoma (PCNSL) is a rare extranodal lymphomatous malignancy that affects the brain, spinal cord, leptomeninges, or vitreoretinal space, without evidence of systemic involvement. The diagnosis of PCNSL requires a high
Autor:
Prakash Priyadarshi Praharaj, Debasna P. Panigrahi, Bishnu Prasad Behera, Kewal Kumar Mahapatra, Shankargouda Patil, Amruta Singh, Rohan Dhiman, Srimanta Patra, Soumya Ranjan Mishra, Chandra Sekhar Bhol, Sujit K. Bhutia, Samir Kumar Patra
Publikováno v:
Seminars in Cancer Biology. 83:399-412
Tumour-promoting inflammation is a critical hallmark in cancer development, and inflammasomes are well-known regulators of inflammatory processes within the tumour microenvironment. Different inflammasome components along with the adaptor, apoptosis-
Thrombus formation is dependent on the interaction of platelets, leukocytes and endothelial cells as well as proteins of the coagulation cascade. This interaction is tightly controlled by phospho-regulated pathways involving protein kinase CK2. A gro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f92a1e8f015cf6edcffd7aa22cd6d13c
Autor:
Augustine M.K. Choi, Mi-Ae Park, Mijin Yun, Chun K. Kim, Kiichi Nakahira, Jong Seok Moon, Maria Haslip, Ilias I. Siempos, Judie A. Howrylak, Patty J. Lee, Seonmin Lee, Stefan W. Ryter
Publikováno v:
Journal of Clinical Investigation. 133
Cellular lipid metabolism has been linked to immune responses; however, the precise mechanisms by which de novo fatty acid synthesis can regulate inflammatory responses remain unclear. The NLRP3 inflammasome serves as a platform for caspase-1–depen
Publikováno v:
Blood. 139:1973-1986
Disseminated intravascular coagulation (DIC) is a syndrome triggered by infectious and noninfectious pathologies characterized by excessive generation of thrombin within the vasculature and widespread proteolytic conversion of fibrinogen. Despite div
Autor:
Jian-Feng Liu, You Jin, Jian-Guo Chen, Lan Ni, Zhuang-Li Hu, Cong Ma, Jia-Jing Lu, Shi-Ge Xue, Yi Luo, Hui-Ling Zheng, Fang Wang, Wen-Long Xie, Hou-Hong Li
Publikováno v:
Biological Psychiatry. 91:593-603
Background Depression is a common psychiatric disorder associated with the defects in GABAergic neurotransmission. α-Dystroglycan (α-DG), a cell adhesion molecule known to be essential for skeletal muscle integrity, is also present at inhibitory sy
Autor:
Monique Verhaegen, Arul M. Chinnaiyan, Julia VanGoor, Drew Pratt, Doris Mangelberger, Xuhong Cao, Fengyun Su, Andrzej A. Dlugosz, Jean C. Tien, Josh N. Vo, Jae Eun Choi, Paul W. Harms, Vincent T. Ma, Saravana M. Dhanasekaran
Publikováno v:
J Invest Dermatol
Merkel cell carcinoma (MCC) is an aggressive cutaneous neuroendocrine carcinoma that is classified as Merkel cell polyomavirus (MCPyV)-positive or virus-negative. Epigenetic changes, such as DNA methylation, can alter gene expression and influence ca
Autor:
Hiroshi Imanaga, Tatsuya Terasaki, Koichi Akashi, Kensuke Sasaki, Fumihiko Nakao, Takeshi Inukai, Jumpei Nogami, Takahiro Maeda, Els Verhoeyen, Takuji Yamauchi, Koshi Akahane, Yuichiro Semba
Publikováno v:
Blood
Acute lymphoblastic leukemia (ALL) harboring the IgH-CRLF2 rearrangement (IgH-CRLF2-r) exhibits poor clinical outcomes and is the most common subtype of Philadelphia chromosome-like acute lymphoblastic leukemia (Ph-like ALL). While multiple chemother
Publikováno v:
Bioengineered, Vol 13, Iss 2, Pp 3620-3633 (2022)
Preeclampsia (PE) is a pregnancy disorder characterized by excessive trophoblast cell death. This study aims to explore the exact mechanism of the ubiquitination level of FUN14 domain containing 1 (FUNDC1) in mitophagy and injury in hypoxic trophobla
Autor:
Tales Vicari Pascini, Thiago Luiz Alves e Silva, Yeong Je Jeong, Zarna Rajeshkumar Pala, Joel Vega-Rodríguez, Brendan Sweeney, Medard Ernest
Publikováno v:
Trends Parasitol
Plasmodium and other vector-borne pathogens have evolved mechanisms to hijack the mammalian fibrinolytic system to facilitate infection of the human host and the invertebrate vector. Plasmin, the effector protease of fibrinolysis, maintains homeostas