Zobrazeno 1 - 10
of 3 100
pro vyhledávání: ''
Autor:
Nandan Mysore Varadarajan, Liam Keegan, Praveenkumar Rengaraj, Dragana Vukić, Štěpánka Vaňáčová, Ales Obrdlik, Mary A. O’Connell
Publikováno v:
RNA Biology
article-version (VoR) Version of Record
article-version (VoR) Version of Record
Eukaryotic mRNAs are modified by several chemical marks which have significant impacts on mRNA biology, gene expression, and cellular metabolism as well as on the survival and development of the whole organism. The most abundant and well-studied mRNA
Publikováno v:
Journal of Molecular Histology. 52:643-650
Lung diseases, including asthma, pose a serious global health issue. Loss of mitochondrial function and decreased mitochondrial biogenesis play pivotal roles in the initiation and progression of chronic lung diseases. Thus, maintaining mitochondrial
Autor:
Katherine A. Hajjar, Mary M. Ruisi, Maria T. DeSancho, Neha Kumar, Huigen Chen, Hannah Fassel
Publikováno v:
Blood. 137:2221-2230
Reduced plasma fibrinolysis has been identified as a potential risk factor for venous thromboembolism (VTE), but the role of cell surface fibrinolysis in VTE is unknown. The annexin A2/S100A10 complex serves as a coreceptor for plasminogen and tissue
Publikováno v:
Seminars in Cell & Developmental Biology. 111:126-134
Tight regulation of the immune response is fundamental for efficient pathogen clearance and to prevent excessive inflammation. Long non-coding RNAs (lncRNAs) have emerged as potent regulators of the innate and adaptive immune responses to viral patho
Autor:
Mayumi Sugita, Kimihito Cojin Kawabata, Martin Carroll, Sarah Wyman, Bas J. Wouters, Zhengming Chen, Michael Albert, Winnie Yip, Cem Meydan, Srinjoy Goswami, Hongliang Zong, Ruud Delwel, Ari Melnick, Gail J. Roboz, Monica L. Guzman, Christopher E. Mason
Publikováno v:
Blood, 137(6), 812-825. American Society of Hematology
Blood
Blood
B-cell lymphoma 6 (BCL6) is a transcription repressor and proto-oncogene that plays a crucial role in the innate and adaptive immune system and lymphoid neoplasms. However, its role in myeloid malignancies remains unclear. Here, we explored the role
Publikováno v:
Aging (Albany NY)
Chemoresistance is a common limitation for successful treatment of glioblastoma multiforme (GBM). Recently, virus infections have been demonstrated to be associated with tumorigenesis and chemoresistance in tumors. However, the role of infection-rela
Publikováno v:
J Innate Immun
Journal of Innate Immunity, Pp 1-14 (2021)
Journal of Innate Immunity, Pp 1-14 (2021)
Regulation of proinflammatory cytokine expression is critical in the face of single-stranded RNA (ssRNA) virus infections. Many viruses, including coronavirus and influenza virus, wreak havoc on the control of cytokine expression, leading to the form
Publikováno v:
Cell Biology International
The bone marrow microenvironment plays an essential role in multiple myeloma (MM) progression. We aimed to explore the alterations of levels of long noncoding RNAs and messenger RNAs (mRNAs), derived from exosomes in peripheral blood, in resistance t
Publikováno v:
Journal of Cellular and Molecular Medicine
Tumour drug resistance is one of the most urgent issues faced by anti‐tumour therapies. P‐glycoprotein (P‐gp) has been reported to be correlated with drug resistance. In this study, we aimed to study the synergistic effect of fluorouracil (5FU)
Autor:
Claire F. Verschraegen, Jiahan Ding, Wen Jia Zuo, Jianjun Zou, Yi Xiao, Virginia G. Kaklamani, Zhong Hua Wang, Yi-Zhou Jiang, Ding Ma, Yin Liu, Lin Jiang, Xiaoyu Zhu, Xin Hu, Zhi Ming Shao, Daniel G. Stover
Publikováno v:
Cell Research
Triple-negative breast cancer (TNBC) is a highly heterogeneous disease, and molecular subtyping may result in improved diagnostic precision and targeted therapies. Our previous study classified TNBCs into four subtypes with putative therapeutic targe