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Autor:
Paul Milne, Helen J. Blair, Cornelia Eckert, Zoya Kingsbury, Matthew Collin, Anetta Ptasinska, Alex Elder, Roderick Skinner, Janine Stutterheim, Jennifer Becq, Elena Zerkalenkova, Constanze Bonifer, Denis M. Schewe, Peter N. Cockerill, N Martinez-Soria, Oskar A. Haas, Peter Carey, Katarzyna Szoltysek, Deepali Pal, Hesta McNeill, Claus Meyer, Maria Rosaria Imperato, James C. Mulloy, Mark Wunderlich, Catherine Cargo, Paul Evans, Sarah E. Fordham, Shan Lin, Pierre Cauchy, Y Shi, Simon Bailey, Salam A. Assi, Rolf Marschalek, Josef Vormoor, Olaf Heidenreich, A Komkov, Michael J. Thirman, Simon Bomken, Ricky Tirtakusuma, Sirintra Nakjang, Fotini Vogiatzi, James M. Allan, Lisa J. Russell, Jayne Y. Hehir-Kwa, Muzlifah Haniffa, Yulia Olshanskaya, Vasily V. Grinev, Christine J. Harrison, Venetia Bigley, Daniel Williamson, Alex Smith, Natalia Miakova
Publikováno v:
Blood. 140:1875-1890
The fusion gene MLL-AF4 defines a high-risk subtype of pro-B acute lymphoblastic leukaemia. However, relapse can be associated with a switch from acute lymphoblastic to acute myeloid leukaemia. Here we show that these myeloid relapses share oncogene
Autor:
Lauren Schaff, Christian Grommes
Publikováno v:
Blood. 140:971-979
Primary central nervous system lymphoma (PCNSL) is a rare extranodal lymphomatous malignancy that affects the brain, spinal cord, leptomeninges, or vitreoretinal space, without evidence of systemic involvement. The diagnosis of PCNSL requires a high
Publikováno v:
Blood
As the coronavirus disease (COVID-19) pandemic led to a global health crisis, there were limited treatment options and no prophylactic therapies for those exposed to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Convalescent plasma is
Autor:
Katharina Jahn, David Dreifuss, Ivan Topolsky, Anina Kull, Pravin Ganesanandamoorthy, Xavier Fernandez-Cassi, Carola Bänziger, Alexander J. Devaux, Elyse Stachler, Lea Caduff, Federica Cariti, Alex Tuñas Corzón, Lara Fuhrmann, Chaoran Chen, Kim Philipp Jablonski, Sarah Nadeau, Mirjam Feldkamp, Christian Beisel, Catharine Aquino, Tanja Stadler, Christoph Ort, Tamar Kohn, Timothy R. Julian, Niko Beerenwinkel
Publikováno v:
nature microbiology
Nature Microbiology, 7 (8)
Nature Microbiology, 7 (8)
The continuing emergence of SARS-CoV-2 variants of concern and variants of interest emphasizes the need for early detection and epidemiological surveillance of novel variants. We used genomic sequencing of 122 wastewater samples from three locations
Publikováno v:
Blood. 139:2130-2144
Modulation of neutrophil recruitment and function is crucial for targeting inflammatory cells to sites of infection to combat invading pathogens while, at the same time, limiting host tissue injury or autoimmunity. The underlying mechanisms regulatin
Autor:
Zhiwen Wu, Toshiaki Yoshikawa, Yusuke Takahashi, Satoshi Inoue, Hirokazu Matsushita, Hitomi Kasuya, Hiroaki Kuroda, Yuki Kagoya, Shiro Suzuki, Waki Hosoda
Publikováno v:
Blood. 139:2156-2172
Adoptive cancer immunotherapy can induce objective clinical efficacy in patients with advanced cancer; however, a sustained response is achieved in a minority of cases. The persistence of infused T cells is an essential determinant of a durable thera
Autor:
Michaela Debreova, Martina Culenova, Veronika Smolinska, Andreas Nicodemou, Maria Csobonyeiova, Lubos Danisovic
Publikováno v:
Cytotherapy. 24:365-375
Rheumatoid arthritis (RA) is a chronic inflammatory disease that affects the synovial joints and, if not treated properly, can lead to multiple progressive articular and extra-articular damage. Its pathogenesis is primarily associated with an inadequ
Autor:
Pooria Fallah, Huling Lyu, Dan Burch, Deborah Foyle, Thomas G.H. Diekwisch, Xianghong Luan, Xiaofeng Zhou, Mirali Pandya
Publikováno v:
Semin Cell Dev Biol
Periodontal disease is an inflammatory reaction of the periodontal tissues to oral pathogens. In the present review we discuss the intricate effects of a regulatory network of gene expression modulators, microRNAs (miRNAs), as they affect periodontal
Autor:
Robert K. Bradley, Patrick Nugent, Khrystyna North, Jasmine Naru, Eunhee Kim, Janine O. Ilagan, Joseph Pangallo, Sergei Doulatov, Martina Sarchi, Derek L. Stirewalt, Arvind R. Subramaniam, Rochelle Bergantinos, Massiel Chavez Stolla, Omar Abdel-Wahab, Janis L. Abkowitz, Courtnee Clough
Publikováno v:
Blood. 139:2038-2049
SF3B1 splicing factor mutations are near-universally found in myelodysplastic syndromes (MDS) with ring sideroblasts (RS), a clonal hematopoietic disorder characterized by abnormal erythroid cells with iron-loaded mitochondria. Despite this remarkabl
Autor:
Markus G. Manz, Dirk Loeffler, Arne Wehling, Florin Schneiter, Tobias Kull, Claudia Lengerke, Timm Schroeder, Weijia Wang
Publikováno v:
Blood, 139 (13)
Blood
Blood
Understanding human hematopoietic stem cell fate control is important for its improved therapeutic manipulation. Asymmetric cell division, the asymmetric inheritance of factors during division instructing future daughter cell fates, was recently desc