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Autor:
O. Nalcaci, Hanns-Rudolf Paur, Silvia Diabaté, Clarissa Marquardt, Henning Bockhorn, Carsten Weiss, A. Panas, Sonja Mülhopt, Werner Baumann
In cell culture studies, foetal calf serum (FCS) comprising numerous different proteins is added, which might coat the surface of engineered nanomaterials (ENMs) and thus could profoundly alter their biological activities. In this study, a panel of i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0ac3b005a3bed1de912acd448b43311
Publikováno v:
Journal of Neuroinflammation, Vol 18, Iss 1, Pp 1-24 (2021)
Journal of Neuroinflammation
Journal of Neuroinflammation
Background Neuroinflammation is thought to be a cause of Alzheimer’s disease (AD), which is partly caused by inadequate mitophagy. As a receptor of mitophagy, we aimed to reveal the regulatory roles of optineurin (OPTN) on neuroinflammation in the
Autor:
Minli Jin, Xia Li, Yunshan Ye, Yawei Tang, Bo Yuan, Xiaokang Ye, Guan Wang, Ziran Bai, Jing Wei
Publikováno v:
Immunology Letters. 239:88-95
Leptin is over-secreted in many autoimmune diseases, which can promote dendritic cells (DCs) maturation and up-regulate the expression of inflammatory cytokines, but the underlying mechanisms are not fully elucidated. Considering the major role of le
Autor:
Xinxin Ge, Kangxi Zhou, Liuxia Yuan, Yueyue Sun, Su-Qin Zhang, Zhongren Ding, Bin Cheng, Mengnan Yang, Changgeng Ruan, Rong Yan, Ningbo Pang, Kesheng Dai, Jincai Luo, Honglei Ye
Publikováno v:
Cell Death and Disease, Vol 12, Iss 11, Pp 1-13 (2021)
Cell Death & Disease
Cell Death & Disease
Platelets are generated from the cytoplasm of megakaryocytes (MKs) via actin cytoskeleton reorganization. Zyxin is a focal adhesion protein and wildly expressed in eukaryotes to regulate actin remodeling. Zyxin is upregulated during megakaryocytic di
Autor:
Jacquelyn J. Maher, Aras N. Mattis, Ke Liu, Tao Su, Caitlin Peaslee, Sneha Rao, Cristina Esteva-Font, Julie B. Sneddon, Antonio Munoz-Howell, Zhe Liu, Caroline C. Duwaerts, Marisa W. Medina
Publikováno v:
Hepatology (Baltimore, Md.), vol 74, iss 4
Hepatology
Hepatology
BACKGROUND AND AIMS: Induced pluripotent stem cells (iPSCs) provide an important tool for the generation of patient-derived cells, including hepatocyte-like cells, by developmental cues through an endoderm intermediate. However, most iPSC lines fail
Autor:
Xiuying Li, Tiao Li, Seyed Mehdi Nouraie, Janet S. Lee, Kong Chen, Georgios D Kitsios, Rama K. Mallampalli, Bryan J. McVerry, Yingze Zhang, Yandong Lai, Chunbin Zou, Toru Nyunoya
Publikováno v:
Cell Death and Disease, Vol 12, Iss 9, Pp 1-11 (2021)
Cell Death & Disease
Cell Death & Disease
Lung epithelial cell death is a prominent feature of acute lung injury and acute respiratory distress syndrome (ALI/ARDS), which results from severe pulmonary infection leading to respiratory failure. Multiple mechanisms are believed to contribute to
Autor:
Jie Tang, Seth Malmersjö, Kevin J. Paavola, Geoffrey Horner, Bernard B. Allan, Lee B. Rivera, Jian Luo, Bin Fan, Vicky Y. Lin, Peirong Chen, Alan Kutach, Raj Haldankar, Julie M. Roda, Martina Molgora, Marco Colonna, Jer-Yuan Hsu, Kyle P. O'Hollaren, Chun Chu, Christina Song, Hung-I H. Chen, Joshua S. Lichtman, Zhen Zhang, Daniel D. Kaplan, Kalyani Mondal, Wenhui Liu, Avantika Kekatpure, Betty Chan Li, Shelley R. Starck, Wei Guo, Suzanne Christine Crawley, Mark J. Solloway, Nikolai A. Sharkov, Richard Ventura, Yan Wang
Publikováno v:
Cancer Immunology Research. 9:1283-1297
Suppressive myeloid cells inhibit antitumor immunity by preventing T-cell responses. Immunoglobulin-like transcript 3 (ILT3; also known as LILRB4) is highly expressed on tumor-associated myeloid cells and promotes their suppressive phenotype. However
Autor:
Karla K. Rodgers, Gertrude Kyere-Davies, Asif Alam Chowdhury, Neha Chataut, Bhupinder Singh, Gaurav Kumar, Shanjana Awasthi, Negar S. Rahman, Jacob Beierle, Jun Xie, Vibhudutta Awasthi, Vijay Ramani
Publikováno v:
ImmunoHorizons
The TLR4-interacting SPA4 peptide suppresses inflammation. We assessed the structural and physicochemical properties and binding of SPA4 peptide to TLR4–MD2. We also studied the changes at the whole transcriptome level, cell morphology, viability,
Autor:
Yang Yang, Sahana Manohar-Sindhu, Thomas C. Foster, Daohong Zhou, Dmitry O. Traktuev, Yonghan He, Vivekananda Budamagunta
Publikováno v:
Aging (Albany NY)
Aging is associated with an increased susceptibility to adverse inflammatory conditions such as sepsis and cytokine storm. We hypothesized that senescent cells (SnCs) play a central role in this age-associated pathology in part due to their expressio
Autor:
Sarah J. Richardson, Noel G. Morgan, Jay Young, Edward C. Burnett, Jessica L. E. Hill, Katie Partridge, Kyle C. A. Wedgwood, Mark Russell, Jessica R. Chaffey, Kaiyven A. Leslie, Pouria Akhbari, Shalinee Dhayal
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Scientific Reports
Scientific Reports
The generation of a human pancreatic beta cell line which reproduces the responses seen in primary beta cells, but is amenable to propagation in culture, has long been an important goal in diabetes research. This is particularly true for studies focu