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Autor:
E. Vazi, F. Holanda, C.V. Cardoso, Neife Aparecida Guinaim dos Santos, Eduardo Fernandes Bondan, Maria Marlene Martins
Publikováno v:
Research in Veterinary Science. 138:39-48
Methotrexate (MTX), an antifolate drug, is widely used in chemotherapeutic protocols for metastatic and primary brain tumors and some autoimmune diseases. Its efficacy for brain tumors is limited by the high incidence of central nervous system (CNS)
Autor:
Mater H. Mahnashi, Mohammed Abdul Rahman Alshahrani, Muhammad Akram, Zeeshan Jabbar, Hafiz Muhammad Irfan, Mulazim Hussain Asim, Ahmed Saif, Mohammed Alshehri, Alamgeer, Saeed A. Asiri
Publikováno v:
Inflammopharmacology. 29:1413-1425
Venlafaxine is a serotonin-norepinephrine reuptake inhibitor used to treat depression. Previous studies demonstrated its anti-nociceptive and anti-inflammatory activities through the suppression of pro-inflammatory cytokines. Present research aimed t
Autor:
Bruno Geloneze, Daniel Minutti de Oliveira, Sofia Helena Valente de Lemos-Marini, Juliano H. Borges, Gil Guerra-Júnior, Ezequiel Moreira Gonçalves
Publikováno v:
Lipids. 56:101-110
We aimed to compare detailed fat distribution and lipid profile between young adults with congenital adrenal hyperplasia due to 21-hydroxylase enzyme deficiency and a control group. We also verified independent associations of treatment duration and
Autor:
Sawsan A. Zaitone, Nagla A. El-Sherbeeny, Afaf T Ibrahiem, Howaida S Ali, Eman A. Toraih, Noha E. Farag
Publikováno v:
Archives of Pharmacal Research. 43:724-734
This work tested the role of carbamazepine in alleviating alloxan-induced diabetic neuropathy and the enhancement of spinal plasticity. Mice were randomized into four groups: normal, control, carbamazepine (25-mg/kg) and carbamazepine (50-mg/kg). Nin
Publikováno v:
Digestive Diseases and Sciences. 66:796-801
Background in liver cirrhosis, a marked splanchnic vasodilation causes an increase in portal blood flow, contributing to the development of portal hypertension. Aim To evaluate if, in experimental cirrhosis, a different vascular reactivity exists bet
Autor:
Lirong Zhang, Xiao-bo Zhong, Hao Jie Zhu, Junjie Zhu, Jingcheng Xiao, Pei Wang, José E. Manautou, Xueyan Shao, Jian Shi, Yifan Bao, Xiaochao Ma
Publikováno v:
Drug Metab Dispos
Drug-induced liver injury (DILI) is a global medical problem. The risk of DILI is often related to expression and activities of drug-metabolizing enzymes, especially cytochrome P450s (P450s). However, changes on expression and activities of P450s aft
Autor:
Kristin S. Warren, Jacobus P. Raath, Silke Pfitzer, Leith C. R. Meyer, Michael Laurence, Rebecca Vaughan-Higgins, Liesel L. Laubscher
Publikováno v:
Veterinary Anaesthesia and Analgesia. 46:796-806
Objective This study aimed to determine whether the R-enantiomer of 8-hydroxy-2-(di-n-propylamino) tetralin (R-8-OH-DPAT) alleviates respiratory depression in antelope species immobilised with etorphine. The experiment also aimed to establish the mos
Autor:
Jiejing Kai, Ling Hui Zeng, Binbin Zhang, Furong Liu, Meiling Wu, Luna Liu, Jingyin Dong, Feng Zhu
Publikováno v:
International Journal of Neuroscience. 130:9-18
Aims: Previous studies have demonstrated that rapamycin prevents seizure-induced anxiety-like behaviors. However, rapamycin had been used at a higher dose of 3 mg/kg and resulted in side effects in immature animals. This work was designed to explore
Autor:
Dong Yu, Ya Jiang, Mu-Lan Wang, Fan Lei, Shilin Yang, Chengliang Zha, Yulin Feng, Lijun Du, Ying-Ying Luo, Jun Li, Qin Gong
Publikováno v:
Pharmacology Research & Perspectives
Pharmacology Research & Perspectives, Vol 9, Iss 6, Pp n/a-n/a (2021)
Pharmacology Research & Perspectives, Vol 9, Iss 6, Pp n/a-n/a (2021)
Cisplatin (CP), an anticancer drug, often causes kidney damage. However, the mechanism of CP‐induced acute kidney injury (AKI) is not completely understood. AKI was induced by intravenous injection (i.v.) of cisplatin at doses of 5, 8, and 10 mg/kg
Publikováno v:
Journal of clinical psychopharmacology. 41(3)
Purpose This study aimed to investigate the combined effects of dose, age, sex, body weight, and smoking on plasma concentrations of olanzapine (OLA) and N-desmethyl olanzapine (DMO) in Chinese inpatients with schizophrenia. Methods A retrospective s