Zobrazeno 1 - 1
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pro vyhledávání: '"Abigail Sveden"'
Autor:
Julia K. Goodrich, Moriel Singer-Berk, Rachel Son, Abigail Sveden, Jordan Wood, Eleina England, Joanne B. Cole, Ben Weisburd, Nick Watts, Lizz Caulkins, Peter Dornbos, Ryan Koesterer, Zachary Zappala, Haichen Zhang, Kristin A. Maloney, Andy Dahl, Carlos A. Aguilar-Salinas, Gil Atzmon, Francisco Barajas-Olmos, Nir Barzilai, John Blangero, Eric Boerwinkle, Lori L. Bonnycastle, Erwin Bottinger, Donald W. Bowden, Federico Centeno-Cruz, John C. Chambers, Nathalie Chami, Edmund Chan, Juliana Chan, Ching-Yu Cheng, Yoon Shin Cho, Cecilia Contreras-Cubas, Emilio Córdova, Adolfo Correa, Ralph A. DeFronzo, Ravindranath Duggirala, Josée Dupuis, Ma Eugenia Garay-Sevilla, Humberto García-Ortiz, Christian Gieger, Benjamin Glaser, Clicerio González-Villalpando, Ma Elena Gonzalez, Niels Grarup, Leif Groop, Myron Gross, Christopher Haiman, Sohee Han, Craig L. Hanis, Torben Hansen, Nancy L. Heard-Costa, Brian E. Henderson, Juan Manuel Malacara Hernandez, Mi Yeong Hwang, Sergio Islas-Andrade, Marit E. Jørgensen, Hyun Min Kang, Bong-Jo Kim, Young Jin Kim, Heikki A. Koistinen, Jaspal Singh Kooner, Johanna Kuusisto, Soo-Heon Kwak, Markku Laakso, Leslie Lange, Jong-Young Lee, Juyoung Lee, Donna M. Lehman, Allan Linneberg, Jianjun Liu, Ruth J. F. Loos, Valeriya Lyssenko, Ronald C. W. Ma, Angélica Martínez-Hernández, James B. Meigs, Thomas Meitinger, Elvia Mendoza-Caamal, Karen L. Mohlke, Andrew D. Morris, Alanna C. Morrison, Maggie C. Y. Ng, Peter M. Nilsson, Christopher J. O’Donnell, Lorena Orozco, Colin N. A. Palmer, Kyong Soo Park, Wendy S. Post, Oluf Pedersen, Michael Preuss, Bruce M. Psaty, Alexander P. Reiner, Cristina Revilla-Monsalve, Stephen S. Rich, Jerome I. Rotter, Danish Saleheen, Claudia Schurmann, Xueling Sim, Rob Sladek, Kerrin S. Small, Wing Yee So, Timothy D. Spector, Konstantin Strauch, Tim M. Strom, E. Shyong Tai, Claudia H. T. Tam, Yik Ying Teo, Farook Thameem, Brian Tomlinson, Russell P. Tracy, Tiinamaija Tuomi, Jaakko Tuomilehto, Teresa Tusié-Luna, Rob M. van Dam, Ramachandran S. Vasan, James G. Wilson, Daniel R. Witte, Tien-Yin Wong, AMP-T2D-GENES Consortia, Noël P. Burtt, Noah Zaitlen, Mark I. McCarthy, Michael Boehnke, Toni I. Pollin, Jason Flannick, Josep M. Mercader, Anne O’Donnell-Luria, Samantha Baxter, Jose C. Florez, Daniel G. MacArthur, Miriam S. Udler
Publikováno v:
Nature Communications
Goodrich, J K, Singer-Berk, M, Son, R, Sveden, A, Wood, J, England, E, Cole, J B, Weisburd, B, Watts, N, Caulkins, L, Dornbos, P, Koesterer, R, Zappala, Z, Zhang, H, Maloney, K A, Dahl, A, Aguilar-Salinas, C A, Atzmon, G, Barajas-Olmos, F, Barzilai, N, Blangero, J, Boerwinkle, E, Bonnycastle, L L, Bottinger, E, Bowden, D W, Centeno-Cruz, F, Chambers, J C, Chami, N, Chan, E, Chan, J, Cheng, C Y, Cho, Y S, Contreras-Cubas, C, Córdova, E, Correa, A, DeFronzo, R A, Duggirala, R, Dupuis, J, Garay-Sevilla, M E, García-Ortiz, H, Gieger, C, Glaser, B, González-Villalpando, C, Gonzalez, M E, Grarup, N, Groop, L, Gross, M, Hansen, T, Linneberg, A, Pedersen, O & AMP-T2D-GENES Consortia 2021, ' Determinants of penetrance and variable expressivity in monogenic metabolic conditions across 77,184 exomes ', Nature Communications, vol. 12, 3505 . https://doi.org/10.1038/s41467-021-23556-4
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Repisalud
Instituto de Salud Carlos III (ISCIII)
Goodrich, J K, Singer-Berk, M, Son, R, Sveden, A, Wood, J, England, E, Cole, J B, Weisburd, B, Watts, N, Caulkins, L, Dornbos, P, Koesterer, R, Zappala, Z, Zhang, H, Maloney, K A, Dahl, A, Aguilar-Salinas, C A, Atzmon, G, Barajas-Olmos, F, Barzilai, N, Blangero, J, Boerwinkle, E, Bonnycastle, L L, Bottinger, E, Bowden, D W, Centeno-Cruz, F, Chambers, J C, Chami, N, Chan, E, Chan, J, Cheng, C Y, Cho, Y S, Contreras-Cubas, C, Córdova, E, Correa, A, DeFronzo, R A, Duggirala, R, Dupuis, J, Garay-Sevilla, M E, García-Ortiz, H, Gieger, C, Glaser, B, González-Villalpando, C, Gonzalez, M E, Grarup, N, Groop, L, Gross, M, Haiman, C A, Han, S, Hanis, C L, Hansen, T, Heard-Costa, N L, Jørgensen, M E, Pedersen, O, Witte, D R & AMP-T2D-GENES Consortia 2021, ' Determinants of penetrance and variable expressivity in monogenic metabolic conditions across 77,184 exomes ', Nature Communications, vol. 12, 3505 . https://doi.org/10.1038/s41467-021-23556-4
AMP-T2D-GENES Consortia 2021, ' Determinants of penetrance and variable expressivity in monogenic metabolic conditions across 77,184 exomes ', Nature Communications, vol. 12, no. 1, 3505 . https://doi.org/10.1038/s41467-021-23556-4
Goodrich, J K, Singer-Berk, M, Son, R, Sveden, A, Wood, J, England, E, Cole, J B, Weisburd, B, Watts, N, Caulkins, L, Dornbos, P, Koesterer, R, Zappala, Z, Zhang, H, Maloney, K A, Dahl, A, Aguilar-Salinas, C A, Atzmon, G, Barajas-Olmos, F, Barzilai, N, Blangero, J, Boerwinkle, E, Bonnycastle, L L, Bottinger, E, Bowden, D W, Centeno-Cruz, F, Chambers, J C, Chami, N, Chan, E, Chan, J, Cheng, C Y, Cho, Y S, Contreras-Cubas, C, Córdova, E, Correa, A, DeFronzo, R A, Duggirala, R, Dupuis, J, Garay-Sevilla, M E, García-Ortiz, H, Gieger, C, Glaser, B, González-Villalpando, C, Gonzalez, M E, Grarup, N, Groop, L, Gross, M, Hansen, T, Linneberg, A, Pedersen, O & AMP-T2D-GENES Consortia 2021, ' Determinants of penetrance and variable expressivity in monogenic metabolic conditions across 77,184 exomes ', Nature Communications, vol. 12, 3505 . https://doi.org/10.1038/s41467-021-23556-4
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Repisalud
Instituto de Salud Carlos III (ISCIII)
Goodrich, J K, Singer-Berk, M, Son, R, Sveden, A, Wood, J, England, E, Cole, J B, Weisburd, B, Watts, N, Caulkins, L, Dornbos, P, Koesterer, R, Zappala, Z, Zhang, H, Maloney, K A, Dahl, A, Aguilar-Salinas, C A, Atzmon, G, Barajas-Olmos, F, Barzilai, N, Blangero, J, Boerwinkle, E, Bonnycastle, L L, Bottinger, E, Bowden, D W, Centeno-Cruz, F, Chambers, J C, Chami, N, Chan, E, Chan, J, Cheng, C Y, Cho, Y S, Contreras-Cubas, C, Córdova, E, Correa, A, DeFronzo, R A, Duggirala, R, Dupuis, J, Garay-Sevilla, M E, García-Ortiz, H, Gieger, C, Glaser, B, González-Villalpando, C, Gonzalez, M E, Grarup, N, Groop, L, Gross, M, Haiman, C A, Han, S, Hanis, C L, Hansen, T, Heard-Costa, N L, Jørgensen, M E, Pedersen, O, Witte, D R & AMP-T2D-GENES Consortia 2021, ' Determinants of penetrance and variable expressivity in monogenic metabolic conditions across 77,184 exomes ', Nature Communications, vol. 12, 3505 . https://doi.org/10.1038/s41467-021-23556-4
AMP-T2D-GENES Consortia 2021, ' Determinants of penetrance and variable expressivity in monogenic metabolic conditions across 77,184 exomes ', Nature Communications, vol. 12, no. 1, 3505 . https://doi.org/10.1038/s41467-021-23556-4
Hundreds of thousands of genetic variants have been reported to cause severe monogenic diseases, but the probability that a variant carrier develops the disease (termed penetrance) is unknown for virtually all of them. Additionally, the clinical util