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Autor:
Paula T. Tonin, Jair C. Soares, João Quevedo, Fernanda F. Gava, Gustavo C. Dal-Pont, Samira S. Valvassori, Roger B. Varela, Camila Ferreira, Monica L. Andersen
Publikováno v:
Pharmacology Biochemistry and Behavior. 183:56-63
The present study evaluated the effects of the coadministration of lithium (Li) and Cel on inflammatory parameters in an animal model of mania induced by dextroamphetamine (D-amph). It was used Wistar rats 60 days old (250–350 g). The animals (n =
Publikováno v:
Pharmacology Biochemistry and Behavior. 183:64-71
Addiction to the psychostimulant Methamphetamine (METH) is characterised by high rates of relapse. Currently there are no approved effective pharmacotherapies for METH dependence. The neuropeptide oxytocin (OXY) potently reduces METH-seeking behaviou
Publikováno v:
Pharmacol Biochem Behav
This study analyzed whether the positive allosteric modulator of metabotropic glutamate receptor type 5 (mGlu5) 3-Cyano-N-(1,3-diphenyl-1H-pyrazol-5-yl) benzamide (CDPPB) would alleviate deficits in prepulse inhibition (PPI) and affect dopamine (DA)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6822689f97def7b414d731b72396426b
https://europepmc.org/articles/PMC9176413/
https://europepmc.org/articles/PMC9176413/
Publikováno v:
Pharmacol Biochem Behav
Over the past two decades, opioid abuse has risen especially among women. In both sexes hippocampal neural circuits involved in associative memory formation and encoding of motivational incentives are critically important in the transition from initi
Autor:
Kristin Ataras, Michael M. Morgan
Publikováno v:
Pharmacol Biochem Behav
Opioids such as morphine are the most effective treatment for pain, but termination of opioid use can produce severe withdrawal symptoms. The present study models this process by using home cage wheel running to assess well-being as a result of pain,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bae32a853df15649ca3c5ed6d8979b05
https://europepmc.org/articles/PMC8429200/
https://europepmc.org/articles/PMC8429200/
Autor:
Kenji Hashimoto, Yukihiko Shirayama, Tomihisa Niitsu, Nobuhisa Kanahara, Yuki Hirose, Yasunori Oda, Hiroshi Kimura, Masaomi Iyo, Kouhei Yoshino, Makoto Kimura
Publikováno v:
Pharmacology, biochemistry, and behavior. 211
Background The excessive blockade of dopamine D2 receptors (DRD2s) with long-term antipsychotic treatment is known to induce a dopamine supersensitivity state (DSS). The mechanism of DSS is speculated to be a compensatory up-regulation of DRD2s, but
Publikováno v:
Pharmacol Biochem Behav
Very few people are able to quit smoking, and therefore it is essential to know which factors contribute to the development of compulsive nicotine use. These studies aimed to investigate if early-adolescent nicotine exposure causes locomotor sensitiz
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::636d139078d8340a74bb5a90ba58dc0c
https://europepmc.org/articles/PMC8284834/
https://europepmc.org/articles/PMC8284834/
Publikováno v:
Pharmacology, biochemistry, and behavior. 209
Neuronal adaptations involving dopaminergic, glutamatergic, and serotonergic neurotransmitter systems are responsible for behavioral sensitization. Because of common underlying mechanisms, cross-sensitization between compounds of different drug class
Publikováno v:
Pharmacol Biochem Behav
These experiments examined whether morphine and cocaine alter the balance between hippocampal and striatal memory systems measured long after drug exposure. Male rats received injections of morphine (5 mg/kg), cocaine (20 mg/kg), or saline for five c
Publikováno v:
Pharmacology, biochemistry, and behavior. 211
Alcohol abuse is a widespread cause of aggressive and impulsive behaviors that impact the users as well as their entourage. However, only a few medications are effective. Recently, cannabidiol has been reported to improve mood disorders and recovery