Zobrazeno 1 - 10
of 114
pro vyhledávání: '"Ulf-Håkan Stenman"'
Autor:
Hannu Koistinen, Ruusu‐Maaria Kovanen, Morley D. Hollenberg, Antoine Dufour, Evette S. Radisky, Ulf‐Håkan Stenman, Jyotsna Batra, Judith Clements, John D. Hooper, Eleftherios Diamandis, Oliver Schilling, Antti Rannikko, Tuomas Mirtti
Publikováno v:
IUBMB Life. 75:493-513
Since the proposition of the pro-invasive activity of proteolytic enzymes over 70 years ago, several roles for proteases in cancer progression have been established. About half of the 473 active human proteases are expressed in the prostate and many
Autor:
Ulf-Håkan Stenman, Hannu Koistinen, Paco Hulpiau, Cedric Hermans, Benedicte Y. De Winter, Nikita Hanning, Ingrid De Meester, Hannah Ceuleers, Maya Berg, Joris G. De Man, Anne-Marie Lambeir, Michelle De bruyn
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 10711, p 10711 (2021)
International journal of molecular sciences
International Journal of Molecular Sciences
Volume 22
Issue 19
International journal of molecular sciences
International Journal of Molecular Sciences
Volume 22
Issue 19
The protease activity in inflammatory bowel disease (IBD) and irritable bowel syndrome has been studied extensively using synthetic fluorogenic substrates targeting specific sets of proteases. We explored activities in colonic tissue from a 2,4,6-tri
Autor:
Hannu Koistinen, Riitta Koistinen, Kristina Hotakainen, Anna Lempiäinen, Kalle Jokelainen, Martti Färkkilä, Ulf-Håkan Stenman
Publikováno v:
Analytical Biochemistry. 648:114681
Trypsin has been identified as a pancreatic protease comprising three isoenzymes, trypsin-1,-2, and-3. However, the gene for trypsinogen-3, PRSS3, also gives rise to additional variants, trypsinogen-4A and B, which differ from trypsinogen-3 only with
Autor:
Ulf-Håkan Stenman, Jouni Jokela, Hannu Koistinen, Kaarina Sivonen, Antti Poso, Matti Wahlsten, Perttu Permi, David P. Fewer, Tomas Strandin, Danillo O. Alvarenga, Matthias Nees, Mikko Metsä-Ketelä, Muhammad N. Ahmed
Publikováno v:
ACS Chemical Biology
Ahmed, M N, Wahlsten, M, Jokela, J, Nees, M, Stenman, U-H, Alvarenga, D O, Strandin, T, Sivonen, K, Poso, A, Permi, P, Metsä-Ketelä, M, Koistinen, H & Fewer, D P 2021, ' Potent Inhibitor of Human Trypsins from the Aeruginosin Family of Natural Products ', ACS chemical biology, vol. 16, no. 11, pp. 2537–2546 . https://doi.org/10.1021/acschembio.1c00611
Ahmed, M N, Wahlsten, M, Jokela, J, Nees, M, Stenman, U-H, Alvarenga, D O, Strandin, T, Sivonen, K, Poso, A, Permi, P, Metsä-Ketelä, M, Koistinen, H & Fewer, D P 2021, ' Potent Inhibitor of Human Trypsins from the Aeruginosin Family of Natural Products ', ACS chemical biology, vol. 16, no. 11, pp. 2537–2546 . https://doi.org/10.1021/acschembio.1c00611
Funding Information: We would like to thank A. Löfhjelm and L. Saari for excellent technical assistance. This work was supported by a Sigrid Jusélius Foundation grant to H.K. and the Academy of Finland funding (321809) to T.S. We would also like to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48dab7b1e75d58c8c8668582248387f2
http://urn.fi/URN:NBN:fi:jyu-202110205299
http://urn.fi/URN:NBN:fi:jyu-202110205299
Autor:
Maija Lahtela-Kakkonen, Kristian Meinander, Henna Ylikangas, Ale Närvänen, Hannu Koistinen, Erik A.A. Wallén, Ulf-Håkan Stenman
Publikováno v:
Biological Chemistry. 397:1229-1235
Kallikrein-related peptidase-3 (KLK3, known also as prostate-specific antigen, PSA) is highly expressed in the prostate. KLK3 possess antiangiogenic activity, which we have found to be related to its proteolytic activity. Thus, it may be possible to
Autor:
Peter Goettig, Brigitta Elsässer, Bettina Mayer, Oliver Schilling, Hans Brandstetter, Martin L. Biniossek, Ulf-Håkan Stenman, Hannu Koistinen
Publikováno v:
Biological chemistry. 399(9)
In humans, three different trypsin-isoenzymes have been described. Of these, trypsin-3 appears to be functionally different from the others. In order to systematically study the specificity of the trypsin-isoenzymes, we utilized proteome-derived pept
Autor:
Suvi Ravela, Leena Kylänpää, Hannu Koistinen, Leena Valmu, Jakob Stenman, Outi Itkonen, Mykola Domanskyy, Esa Hämäläinen, Ulf-Håkan Stenman, Outi Lindström
Publikováno v:
Analytical and bioanalytical chemistry. 410(6)
Pancreatic secretory trypsin inhibitor Kazal type 1 (SPINK1) is a 6420 Da peptide produced by the pancreas, but also by several other tissues and many tumors. Some mutations of the SPINK1 gene, like the one causing amino acid change N34S, have been s
Autor:
Outi Itkonen, Ulf-Håkan Stenman
Publikováno v:
Clinica Chimica Acta. 431:260-269
Tumor-associated trypsin inhibitor (TATI) [also called serine peptidase inhibitor Kazal type1, SPINK1 and, in the pancreas, pancreatic secretory trypsin inhibitor (PSTI)] inhibits trypsin and other serine proteinases and is expressed in several tissu
Autor:
William S.B. Yeung, Philip C.N. Chiu, Laura Hautala, Tuula Salo, Cheuk-Lun Lee, Ulf-Håkan Stenman, Hannu Koistinen
Publikováno v:
Molecular and Cellular Endocrinology. 375:43-52
Both paracrine and autocrine factors are involved in the regulation of trophoblast invasion. One of these factors is human chorionic gonadotropin (hCG), which stimulates trophoblast invasion. The stimulatory activity has especially been ascribed to a
Autor:
Hannu Koistinen, Johanna M. Mattsson, Ulf-Håkan Stenman, Henna Ylikangas, Maija Lahtela-Kakkonen, Antti Poso
Publikováno v:
ChemMedChem. 11(18)
Kallikrein-related peptidase 3 (KLK3) is a prostatic serine protease shown to possess antiangiogenic properties which are exerted via its proteolytic activity. The antiangiogenic effect indicates that KLK3 may slow down the growth of prostate cancer;