Zobrazeno 1 - 10
of 47
pro vyhledávání: '"Thurl E. Harris"'
Publikováno v:
Journal of Lipid Research, Vol 54, Iss 6, Pp 1662-1677 (2013)
Peroxisome proliferator-activated receptor α (PPARα) and PPARγ coactivator 1α (PGC-1α) are crucial transcriptional regulators for genes involved in FA oxidation. Lipin-1 is essential for this increased capacity for β-oxidation in fasted livers,
Externí odkaz:
https://doaj.org/article/2414c553a6794a3eb23614eeb2120fe6
Autor:
Roberto Mendez, Minhaj Shaikh, Michael C. Lemke, Kun Yuan, Adam H. Libby, Dina L. Bai, Mark M. Ross, Thurl E. Harris, Ku-Lung Hsu
Publikováno v:
RSC Chemical Biology.
We provide a family-wide assessment of accessible sites for covalent targeting that combined with AlphaFold revealed predicted small molecule binding pockets for guiding future inhibitor development of the DGK superfamily.
Publikováno v:
Biochemical Journal
The interplay of sphingosine 1-phosphate (S1P) synthetic and degradative enzymes as well as S1P exporters creates concentration gradients that are a fundamental to S1P biology. Extracellular S1P levels, such as in blood and lymph, are high relative t
Autor:
Mitchell E. Granade, Laryssa C. Manigat, Michael C. Lemke, Benjamin W. Purow, Thurl E. Harris
Publikováno v:
Biochem Pharmacol
The diacylglycerol kinase (DGK) family of lipid enzymes catalyzes the conversion of diacylglycerol (DAG) to phosphatidic acid (PA). Both DAG and PA are lipid signaling molecules that are of notable importance in regulating cell processes such as prol
Autor:
Vlad Serbulea, Thurl E. Harris, Katelyn W. Ahern, Clint M Upchurch, Dory E. DeWeese, Paxton Voigt, Akshaya K. Meher, Norbert Leitinger, Gael F. P. Bories
Publikováno v:
Molecular Metabolism
Molecular Metabolism, Vol 7, Iss, Pp 23-34 (2018)
Molecular Metabolism, Vol 7, Iss, Pp 23-34 (2018)
Objective Macrophages control tissue homeostasis and inflammation by sensing and responding to environmental cues. However, the metabolic adaptation of macrophages to oxidative tissue damage and its translation into inflammatory mechanisms remains en
Autor:
Robert T. Lawrence, Sankeerth Takkellapati, Garrett R. Mullins, Jennifer M. Pearson, Mitchell E. Granade, Salome Boroda, Samuel W. Entwisle, Thurl E. Harris, Judit Villén, James M. Eaton
Publikováno v:
Journal of Biological Chemistry. 292:20481-20493
Lipins 1, 2, and 3 are Mg2+-dependent phosphatidic acid phosphatases and catalyze the penultimate step of triacylglycerol synthesis. We have previously investigated the biochemistry of lipins 1 and 2 and shown that di-anionic phosphatidic acid (PA) a
Publikováno v:
Biochemical Pharmacology. 123:29-39
Diacylglycerol kinase alpha (DGKα) catalyzes the conversion of diacylglycerol (DAG) to phosphatidic acid (PA). Recently, DGKα was identified as a therapeutic target in various cancers, as well as in immunotherapy. Application of small-molecule DGK
Autor:
Timothy B. Ware, Andreas Gahlmann, Thurl E. Harris, Kwon-Sik Park, Mingxing Zhang, Mitchell E. Granade, Kee-Beom Kim, Ku-Lung Hsu, Caroline E. Franks
Publikováno v:
Nature chemical biology
C1 domains are lipid-binding modules that regulate membrane activation of kinases, nucleotide exchange factors and other C1-containing proteins to trigger signal transduction. Despite annotation of typical C1 domains as diacylglycerol (DAG) and phorb
Autor:
Faye E Giebink, Thurl E. Harris
Publikováno v:
The FASEB Journal. 33
Autor:
Meagan Hennessy, Thurl E. Harris, Joanna M. Kwiatek, Mitchell E. Granade, Dana Wang, George M. Carman, Azam Hassaninasab, Gil-Soo Han
The mammalian lipin 1 phosphatidate phosphatase is a key regulatory enzyme in lipid metabolism. By catalyzing phosphatidate dephosphorylation, which produces diacylglycerol, the enzyme plays a major role in the synthesis of triacylglycerol and membra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e2e496d8990b3c234e5ac0e823b7200
https://europepmc.org/articles/PMC6378963/
https://europepmc.org/articles/PMC6378963/