Zobrazeno 1 - 10
of 50
pro vyhledávání: '"Raghavendra G. Mirmira"'
Autor:
Pedro Gonzalez-Menendez, Ira Phadke, Meagan E Olive, Axel Joly, Julien Papoin, Hongxia Yan, Jérémy Galtier, Jessica Platon, Sun Woo Sophie Kang, Kathy L. McGraw, Marie Daumur, Marie Pouzolles, Taisuke Kondo, Stéphanie Boireau, Franciane Paul, David J Young, Sylvain Lamure, Raghavendra G Mirmira, Anu Narla, Guillaume Cartron, Cynthia E. Dunbar, Myriam Boyer-Clavel, Natalie Porat-Shliom, Valerie Dardalhon, Valerie S Zimmermann, Marc Sitbon, Thomas Dever, Narla Mohandas, Lydie M Da Costa, Namrata D. Udeshi, Lionel Blanc, Sandrina Kinet, Naomi Taylor
Publikováno v:
Blood.
Metabolic programs contribute to hematopoietic stem and progenitor cell (HSPC) fate, but it is not known whether the metabolic regulation of protein synthesis controls HSPC differentiation. Here, we show that SLC7A1/CAT1-dependent arginine uptake and
Autor:
Melena D. Bellin, Cate Speake, Kevan C. Herold, Raghavendra G. Mirmira, Benjamin Glaser, Sarah A. Tersey, Joshua J. Wilhelm, Sahar Usmani-Brown, Carmella Evans-Molina, Pamela Clark, Daniel Neiman, Alyssa Ylescupidez, Ruth Shemer, Yuval Dor
Publikováno v:
J Clin Endocrinol Metab
Context There is an unmet need for biomarkers of pancreatic beta-cell death to improve early diagnosis of type 1 diabetes, enroll subjects into clinical trials, and assess treatment response. To address this need, several groups developed assays meas
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism.
Publikováno v:
Biomolecules, Vol 11, Iss 717, p 717 (2021)
Biomolecules
Biomolecules
Lipoxygenases (LOXs) are lipid metabolizing enzymes that catalyze the di-oxygenation of polyunsaturated fatty acids to generate active eicosanoid products. 12-lipoxygenases (12-LOXs) primarily oxygenate the 12th carbon of its substrates. Many studies
Autor:
Emily Anderson-Baucum, Wenting Wu, Craig T. Connors, Leah R. Padgett, Morgan A Robertson, Teresa L. Mastracci, Raghavendra G. Mirmira
Publikováno v:
The FASEB Journal
Pancreatic diseases including diabetes and exocrine insufficiency would benefit from therapies that reverse cellular loss and/or restore cellular mass. The identification of molecular pathways that influence cellular growth is therefore critical for
Autor:
Raghavendra G. Mirmira, Abass M. Conteh, Swetha Nakshatri, Marimar Hernandez-Perez, Ryan M. Anderson, Amelia K. Linnemann, Sarah A. Tersey, Christopher A. Reissaus
Publikováno v:
Journal of Biological Chemistry. 294:6612-6620
In type 1 diabetes, an autoimmune event increases oxidative stress in islet β cells, giving rise to cellular dysfunction and apoptosis. Lipoxygenases are enzymes that catalyze the oxygenation of polyunsaturated fatty acids that can form lipid metabo
Autor:
Bruce A. Posner, Joyce J. Repa, Raghavendra G. Mirmira, Jen Chieh Chuang, Lilja Kjalarsdottir, Mridula Vishwanath, Sarah A. Tersey
Publikováno v:
The Journal of Steroid Biochemistry and Molecular Biology. 185:17-26
Aim Vitamin D deficiency in rodents negatively affects glucose-stimulated insulin secretion (GSIS) and human epidemiological studies connect poor vitamin D status with type 2 diabetes. Previous studies performed primarily in rat islets have shown tha
Publikováno v:
The Journal of Clinical Endocrinology and Metabolism
Autor:
Adolfo Garcia-Ocaña, Bernhard Maier, Donald K. Scott, Teresa L. Mastracci, Laura C. Alonso, Esther M. Levasseur, Raghavendra G. Mirmira, Farooq Syed, Emily Anderson-Baucum, Sarah A. Tersey, Amber L. Mosley, Annie R. Piñeros, Kara S. Orr, Kentaro Yamada, Wenting Wu, Ernesto Bernal-Mizrachi, Yunlong Liu
Publikováno v:
Sci Signal
Deoxyhypusine synthase (DHPS) utilizes the polyamine spermidine to catalyze the hypusine modification of the mRNA translation factor eIF5A and promotes oncogenesis through poorly-defined mechanisms. Because germline deletion of Dhps is embryonically
Publikováno v:
PLoS ONE
PLoS ONE, Vol 15, Iss 3, p e0230627 (2020)
PLoS ONE, Vol 15, Iss 3, p e0230627 (2020)
The gene encoding eukaryotic initiation factor 5A (EIF5A) is found in diabetes-susceptibility loci in mouse and human. eIF5A is the only protein known to contain hypusine (hydroxyputrescine lysine), a polyamine-derived amino acid formed post-translat