Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Paul R. August"'
Autor:
Gabriel R. Linares, Justin K. Ichida, Yingxiao Shi, Brandon B Ge, Yichen Li, Jacob Komberg, R. Jeroen Pasterkamp, Davide Trotti, Valerie Hennes, Leonard H. van den Berg, Nicole Koutsodendris, Jason A. Chen, Kaitlin P. Sandor, Vamshidhar R. Vangoor, Louise Menendez, Amy R. Nelson, Michael E. Ward, Tze-Yuan Cheng, Yaoming Wang, Phillip E. Woolwine, Wen-Hsuan Chang, Ketharini Senthilkumar, Kim A. Staats, Mickey Huang, Carina Seah, Alice Zhang, Chris Grunseich, Esther Y. Son, Eric Hendricks, Michael J. Cowan, Paul R. August, Kassandra Kisler, Shih Jong J. Lee, Marcelo P. Coba, Shu Ting Hung, Shaoyu Lin, Brent Wilkinson, N. Wisniewski, Berislav V. Zlokovic, Tohru Sugawara, T. Grant Belgard, Victor Hanson-Smith, Xinmei Wen
Publikováno v:
Nature Medicine, 24(3), 313. Nature Publishing Group
An intronic GGGGCC repeat expansion in C9ORF72 is the most common cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), but the pathogenic mechanism of this repeat remains unclear. Using human induced motor neurons (iMNs), w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a7b18c3fd3677e0457e409e74f97ed0
https://dspace.library.uu.nl/handle/1874/364200
https://dspace.library.uu.nl/handle/1874/364200
Autor:
Elaine Powers, Matthew A. Smicker, Karen J. Chandross, Erica Harnish, Paul S. Wright, Paul R. August, Dragan Cirovic, Joy Prisco, Jane V. Peppard, Catherine A. Rugg
Publikováno v:
SLAS Discovery. 20:382-390
Multiple Sclerosis is a demyelinating disease of the CNS and the primary cause of neurological disability in young adults. Loss of myelinating oligodendrocytes leads to neuronal dysfunction and death and is an important contributing factor to this di
Autor:
Su Wang, Denis Loyaux, Michael A. Smith, Catherine Déon, Jean-Claude Guillemot, Steven A. Goldman, Sébastien Roudières, Philippe Fabre, Paul R. August, Fréderique Guette, Pascual Ferrara, François Autelitano, Qinggong Ping, Romane Auvergne, Vasudeo Badarinarayana, Sridaran Natesan
Publikováno v:
PLoS ONE, Vol 9, Iss 10, p e110316 (2014)
PLoS ONE
PLoS ONE
Glioblastoma multiform (GBM) remains clinical indication with significant "unmet medical need". Innovative new therapy to eliminate residual tumor cells and prevent tumor recurrences is critically needed for this deadly disease. A major challenge of
Autor:
Jean-Marc Herbert, Thomas Leeuw, Paul S. Wright, Paul R. August, Cécile Volle-Challier, Françoise Bono, Jane Peppard, Juan Carlos Izpisua Belmonte, Erika M. Batchelder, Uwe Dietz, Sheng-Lian Yang, Erica Harnish
Articular cartilage, which is mainly composed of collagen II, enables smooth skeletal movement. Degeneration of collagen II can be caused by various events, such as injury, but degeneration especially increases over the course of normal aging. Unfort
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f34b8f5a9ea79ad0c92473b7103605dd
https://europepmc.org/articles/PMC4875386/
https://europepmc.org/articles/PMC4875386/
Publikováno v:
Journal of Bacteriology. 176:4448-4454
Two genes (mcrA and mcrB) from Streptomyces lavendulae that together confer resistance to mitomycin C were identified. This DNA appears to comprise a polycistronic operon with a drug-inducible leaderless mRNA. The deduced amino acid sequence of mcrA
Publikováno v:
Drug Discovery from Nature ISBN: 9783540669470
Drug Discovery from Nature
Drug Discovery from Nature
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2e3dcbbfcb28b92a5cea52d7e3896136
https://doi.org/10.1007/978-3-642-60250-4_12
https://doi.org/10.1007/978-3-642-60250-4_12
Autor:
Chun-Gyu Kim, C. Richard Hutchinson, Li Tang, Tin-Wein Yu, Matthew P. Taylor, Yeo J. Yoon, Paul R. August, Heinz G. Floss, Sandra Ning, Dietmar Hoffmann, Rolf Müller, Xiaohong Zhang
Publikováno v:
Chemistrybiology. 5(2)
Background: The ansamycin class of antibiotics are produced by various Actinomycetes. Their carbon framework arises from the polyketide pathway via a polyketide synthase (PKS) that uses an unusual starter unit. Rifamycin (rif), produced by Amycolatop
Autor:
Frederick J. Schendel, Richard S. Hanson, Michael C. Flickinger, C R Anderson, Paul R. August
Publikováno v:
Scopus-Elsevier
The structural gene coding for citrate synthase from the gram-positive soil isolate Bacillus sp. strain C4 (ATCC 55182) capable of secreting acetic acid at pH 5.0 to 7.0 in the presence of dolime has been cloned from a genomic library by complementat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59ba2e8e14713f8556850b38f499c42b
https://europepmc.org/articles/PMC195212/
https://europepmc.org/articles/PMC195212/
Publikováno v:
Journal of the American Chemical Society. 119:2576-2577